Sex-related difference in food-anticipatory activity of mice

Li, Zhigang; Wang, Yan; Sun, Kevin Kai; Wang, Kangli; Sun, Zhong Sheng; Zhao, Mei; Wang, Jundong

doi:10.1016/j.yhbeh.2015.02.004

Cited by 24 publications

(24 citation statements)

References 52 publications

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“…In a recent study, Liu et al (2014) demonstrated a downregulation of BDNF expression in the male ventromedial hypothalamus during fasting. This observation concurs with the function of BDNF as an anorexic factor to suppress appetite in the hypothalamus (Pelleymounter et al, 1995), which may be associated with the food-intake behavioral change in response to food availability because male animals have higher foodanticipatory activity and food intake after refeeding (Li et al, 2015). There is also a sex-specific response to pharmacologically stimulated BDNF expression in the brain.…”

Section: Sex Differences In Circulating Bdnfsupporting

confidence: 82%

Sex differences in brain‐derived neurotrophic factor signaling and functions

Chan

2016

J of Neuroscience Research

148

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Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays a critical role in numerous neuronal activities. Recent studies report that some functions or action mechanisms of BDNF vary in a sex-dependent manner. In particular, BDNF content in some brain parts and the tendency of developing BDNF-deficient-related diseases like depression is higher in female animals. With the support of other relevant studies, it is suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes. Indeed, the cross-talk between BDNF and sex steroids has been detected for decades and some sex steroids like estrogen have a positive regulatory effect to BDNF expression and signaling. Thus, the sex of animal models used is critical when studying the functions of BDNF in vivo. In this review, we will summarize our current findings on the difference in expression, signaling, and functions of BDNF between sexes. We will also discuss the potential mechanisms in mediating these differential responses with a specific emphasis on sex steroids. By presenting and discussing these findings, we encourage taking sex influences into consideration when designing experiments, interpreting results and drawing conclusions.

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Section: Sex Differences In Circulating Bdnfsupporting

confidence: 82%

Sex differences in brain‐derived neurotrophic factor signaling and functions

Chan

2016

J of Neuroscience Research

148

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“…The role of clock genes in the food-entrainable network has been assessed by challenging clock-compromised mice with time-restricted feeding. Some studies suggest that circadian food anticipation relies on a clock gene-dependent mechanism that at least involves the Period1-3, Bmal1, Cry1-2 and Npas2 genes 23 32 37 39 40 41 42 43 . Others indicate that contribution of clock genes to food entrainment is mild 44 45 , or even non-significant 21 22 46 .…”

Section: Discussionmentioning

confidence: 99%

Rev-erbα in the brain is essential for circadian food entrainment

Delezie

Dumont

Sandu

et al. 2016

Sci Rep

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Foraging is costly in terms of time and energy. An endogenous food-entrainable system allows anticipation of predictable changes of food resources in nature. Yet the molecular mechanism that controls food anticipation in mammals remains elusive. Here we report that deletion of the clock component Rev-erbα impairs food entrainment in mice. Rev-erbα global knockout (GKO) mice subjected to restricted feeding showed reduced elevations of locomotor activity and body temperature prior to mealtime, regardless of the lighting conditions. The failure to properly anticipate food arrival was accompanied by a lack of phase-adjustment to mealtime of the clock protein PERIOD2 in the cerebellum, and by diminished expression of phosphorylated ERK 1/2 (p-ERK) during mealtime in the mediobasal hypothalamus and cerebellum. Furthermore, brain-specific knockout (BKO) mice for Rev-erbα display a defective suprachiasmatic clock, as evidenced by blunted daily activity under a light-dark cycle, altered free-running rhythm in constant darkness and impaired clock gene expression. Notably, brain deletion of Rev-erbα totally prevented food-anticipatory behaviour and thermogenesis. In response to restricted feeding, brain deletion of Rev-erbα impaired changes in clock gene expression in the hippocampus and cerebellum, but not in the liver. Our findings indicate that Rev-erbα is required for neural network-based prediction of food availability.

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“…Sexually divergent responses were also reported in rats subjected to chronic stress, food restriction and intermittent access (2h) to chocolate Ensure (Lenglos, Mitra, Guevremont & Timofeeva, 2013); restraint stress decreased body weight gain in male rats, but not in females, an effect that was blunted by intermittent access to Ensure. FAA, induced by restricted feeding, and which we have previously shown is also expressed prior to scheduled access to HF diet with otherwise ad libitum access to stock diet (Bake, Murphy, Morgan & Mercer, 2014), is also more pronounced in male mice than in females(Li et al, 2015; Michalik, Steele & Mistlberger, 2015).…”

mentioning

confidence: 66%

A spontaneous binge-like eating model in mice using unpredictable once weekly access to palatable diets

et al. 2018

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Many pre-clinical models of binge-like eating involve predictable, scheduled, access to a palatable diet high in fat (HF), where access may be preceded by anticipatory behaviour. Here, to introduce spontaneity into the binge-type consumption of palatable diets, mice were allowed 2 h access on a random day once per week and at a random time within an 8 h window either side of the transition from dark phase to light phase. Despite normal intake of a stock diet prior to unpredictable access to HF diet, mice immediately initiated a substantial eating episode when presented with HF diet. Following this consumption, compensatory hypophagia was observed relative to stock diet-fed controls, and cumulative energy intakes converged. There were no effects of HF diet on body weight or body composition over a 12-week period. Binge-like consumption was also observed on unpredictable access to the complete liquid diet, chocolate Ensure, but not with a 10% sucrose solution. Binge-like responses to unpredictable access to HF diet or Ensure were similar in male and female mice, although there were effects of sex on caloric consumption from stock diet in the compensatory period following palatable diet intake, with higher intakes in females. The timing of the 2h access period relative to light phase transition affected intake of palatable diets, but less robustly than the equivalent effect on stock diet intake during the same timed periods - the diurnal patterning of energy intake was diet sensitive. The large spontaneous binge-like consumption on unpredictable access to either solid or liquid palatable diets in mice of either sex offers the potential to combine these attributes with other manipulations where a developing obesity is part of the binge-like eating phenotype.

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Sex-related difference in food-anticipatory activity of mice

Cited by 24 publications

References 52 publications

Sex differences in brain‐derived neurotrophic factor signaling and functions

Sex differences in brain‐derived neurotrophic factor signaling and functions

Rev-erbα in the brain is essential for circadian food entrainment

A spontaneous binge-like eating model in mice using unpredictable once weekly access to palatable diets

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