Sex-Related Differences in Emotion Recognition in Multi-concussed Athletes

Léveillé, Édith; Guay, Samuel; Blais, Caroline; Scherzer, P.; Beaumont, Louis De

doi:10.1017/s1355617716001004

Cited by 23 publications

(12 citation statements)

References 125 publications

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“…These findings suggest that multiple concussions alter the dominant right-hemisphere response to early EFE processing (Batty & Taylor, 2003; Eimer & Holmes, 2007; Halit et al, 2000; Itier & Taylor, 2002). This right-hemisphere dominance suppression in early stages of EFE processing found in multi-concussed athletes could contribute to the known persistent alterations of the ability to identify and discriminate emotions in multi-concussion athletes (Léveillé et al, 2016).…”

Section: Discussionmentioning

confidence: 97%

“…A recent study demonstrated significant sex-related differences on the processing of emotional stimuli after concussion (Léveillé et al, 2016). Whereas emotion recognition ability was equivalent in female athletes regardless of concussion history, male concussed athletes showed emotion recognition alterations and needed significantly more emotional intensity than unconcussed male counterparts to identify these emotions.…”

Section: Introductionmentioning

confidence: 99%

“…In parallel, alterations of the ability to identify and discriminate emotional facial expressions (EFEs) were found among people who sustained a traumatic brain injury tested either during the acute (<3 months) or the chronic post-injury phase (>3 months) (Green Turner, & Thompson, 2004; Henry, Phillips, Crawford, Ietswaart, & Summers, 2006; Léveillé, Guay, Blais, Scherzer, & De Beaumont, 2016). EFEs are known to be particularly salient stimuli to humans as they are thought of as immediate indicators of affective dispositions in other people (Holmes, Kiss, & Eimer, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Repeated Concussions and Sex on Early Processing of Emotional Facial Expressions as Revealed by Electrophysiology

Carrier-Toutant

Guay

Beaulieu

et al. 2018

J Int Neuropsychol Soc

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Objectives: Concussions affect the processing of emotional stimuli. This study aimed to investigate how sex interacts with concussion effects on early event-related brain potentials (ERP) measures (P1, N1) of emotional facial expressions (EFE) processing in asymptomatic, multi-concussion athletes during an EFE identification task. Methods: Forty control athletes (20 females and 20 males) and 43 multi-concussed athletes (22 females and 21 males), recruited more than 3 months after their last concussion, were tested. Participants completed the Beck Depression Inventory II, the Beck Anxiety Inventory, the Post-Concussion Symptom Scale, and an Emotional Facial Expression Identification Task. Pictures of male and female faces expressing neutral, angry, and happy emotions were randomly presented and the emotion depicted had to be identified as fast as possible during EEG acquisition. Results: Relative to controls, concussed athletes of both sex exhibited a significant suppression of P1 amplitude recorded from the dominant right hemisphere while performing the emotional face expression identification task. The present study also highlighted a sex-specific suppression of the N1 component amplitude after concussion which affected male athletes. Conclusions: These findings suggest that repeated concussions alter the typical pattern of right-hemisphere response dominance to EFE in early stages of EFE processing and that the neurophysiological mechanisms underlying the processing of emotional stimuli are distinctively affected across sex. (JINS, 2018, 24, 673-683)

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Repeated Concussions and Sex on Early Processing of Emotional Facial Expressions as Revealed by Electrophysiology

Carrier-Toutant

Guay

Beaulieu

et al. 2018

J Int Neuropsychol Soc

Self Cite

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“…Léveillé et al (52) reported emotion recognition scores for male and female athletes with a history of two or more concussions, compared to athletes with no concussion history. This study was initially excluded because the focus of the review was moderate-severe TBI, but the task was similar to the morph task described in Rigon et al (26), so results might provide an informative comparison.…”

Section: Sex Differences In Social Cognition In Adults With Tbimentioning

confidence: 99%

Sex and Gender Differences in Emotion Recognition and Theory of Mind After TBI: A Narrative Review and Directions for Future Research

et al. 2020

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A growing body of literature has examined sex differences in a variety of outcomes from moderate-severe traumatic brain injury (TBI), including outcomes for social functioning. Social functioning is an area in which adults with TBI have significant long-term challenges (1-4), and a better understanding of sex and gender differences in this domain may have a significant clinical impact. This paper presents a brief narrative review of current evidence regarding sex differences in one aspect of social functioning in adults with TBI: social cognition, specifically affect recognition and Theory of Mind (ToM). Data from typical adults and adults with TBI are considered in the broader context of common stereotypes about social skills and behaviors in men vs. women. We then discuss considerations for future research on sex-and gender-based differences in social cognition in TBI, and in adults more generally.

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“…These findings demonstrate striking sex differences in the persistent changes in basal gene expression after a subchronic immune challenge. (Importantly, this suggests that differential vulnerability to cognitive decline, memory impairments, and affective disorders (Himanen et al, 2006;Hogue et al, 2003;Lavoie et al, 2017;Léveillé et al, 2017;Liossi et al, 2009;Niemeier et al, 2007;Rainville and Hodes, 2018;Suarez et al, 2015) after illness or injury may be mediated by sex differences in the changes in gene expression and transcriptional regulation that persist long after immune challenge.…”

Section: Discussionmentioning

confidence: 99%

Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge

Tchessalova

Tronson

2019

Preprint

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Acknowledgements:We would like to acknowledge the University of Michigan Bioinformatics core for their expertise and data analysis of differentially expressed genes and the University of Michigan DNA sequencing core for their processing of samples. We would like to sincerely thank Dr. Shigeki Iwase and Christina Vallianatos for their advice, support, and assistance with prepping of the RNA samples. We would also very much like to thank them for allowing us to use their laboratory equipment for RNA extraction.We thank Ms. Brynne Raines, Ms. Melanie Gil, and Ms. Caitlin Posillico for their extensive feedback on this manuscript. ABSTRACTMajor illnesses, including major surgery, heart attack, and sepsis, can cause long-lasting cognitive impairments, depression, and progressive memory decline that persist well after recovery from the original illness. Similarly, in animal models, immune challenge results in impairments of learning and memory as well as increased depression-like behaviors. Although neuroimmune signaling is now well established as playing a crucial role in the modulation of neural functions, how transient immune signaling mediates enduring changes in cognition, memory, and emotion remains unknown. We have recently demonstrated that a series of intermittent injections of lipopolysaccharides over a two-week period resulted in sex-specific patterns of memory deficits that persist at least several months after the end of the immune challenge. Here, we examined the persistent changes in hippocampal gene expression three months after this subchronic systemic immune challenge in males and in females. We used RNA-sequencing as a large-scale, unbiased approach to identify both persistent changes in gene expression long after an immune challenge, and changes in transcriptional response to a subsequent immune challenge. Males and females differed in number and patterns of gene expression in the hippocampus. In males, we observed enduring dysregulation of gene expression three months after the end of a subchronic immune challenge, in the absence of an additional insult. In contrast, females showed few persistent changes under basal conditions, but striking dysregulation of gene expression in response to an additional acute LPS injection. Striking sex differences in the specific genes, pathways, and biological processes affected were observed both after subchronic immune challenge and after a subsequent insult. Thus, subchronic systemic immune activation has enduring and sex-specific consequences for gene expression and response to subsequent stimuli. Such persistent changes in neural functions further suggest that in both males and females, neuroimmune signaling during illness contributes to subsequent vulnerability or resilience to cognitive decline, memory impairments, and affective disorders.

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Sex-Related Differences in Emotion Recognition in Multi-concussed Athletes

Cited by 23 publications

References 125 publications

Effects of Repeated Concussions and Sex on Early Processing of Emotional Facial Expressions as Revealed by Electrophysiology

Effects of Repeated Concussions and Sex on Early Processing of Emotional Facial Expressions as Revealed by Electrophysiology

Sex and Gender Differences in Emotion Recognition and Theory of Mind After TBI: A Narrative Review and Directions for Future Research

Enduring and sex-specific changes in hippocampal gene expression after a subchronic immune challenge

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