2016
DOI: 10.1016/j.jss.2015.09.018
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Sex-related differences in lung inflammation after brain death

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Cited by 14 publications
(31 citation statements)
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References 35 publications
(38 reference statements)
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“…Human and animal studies, mainly in heart and kidney transplantation, have demonstrated a multitude of injurious processes and pathways activated by BD. 34,39,43 However, despite these studies, the BD model has largely been underutilized in LTx studies. Studies in rodents confirm our findings that BD induces the development of a proinflammatory state 44 that has the potential to adversely affect posttransplant outcomes.…”
Section: Donor Brain Death Significantly Exacerbates Lung Allograftmentioning
confidence: 99%
“…Human and animal studies, mainly in heart and kidney transplantation, have demonstrated a multitude of injurious processes and pathways activated by BD. 34,39,43 However, despite these studies, the BD model has largely been underutilized in LTx studies. Studies in rodents confirm our findings that BD induces the development of a proinflammatory state 44 that has the potential to adversely affect posttransplant outcomes.…”
Section: Donor Brain Death Significantly Exacerbates Lung Allograftmentioning
confidence: 99%
“…In pathological conditions, the extent of platelet deposition can contribute to occlusive thrombus formation and thrombocytopenia is reported to lead to increased permeability of systemic and pulmonary vessels in several models and to be associated with vascular leak in clinical conditions [16]. Although previous results showed higher microvascular permeability in female animals after BD [17], the analysis of platelets presence in the lung tissue did not show differences among groups. However, study from Cleary et al [18] showed adhesion of platelets in the lung microvasculature in an inflammatory response induced by LPS that was not associated with thrombus formation, occurring through mechanisms distinct from those mediating neutrophil recruitment or the occurrence of pulmonary emboli.…”
Section: Discussionmentioning
confidence: 76%
“…It is important to consider that platelet activity may be negatively modulated by substances such as NO which is released by several cells [29]. As mentioned earlier, female rats present a higher inflammatory response after BD and higher iNOS and eNOS expression than male rats [12,13]. Srihirun et al [30] showed that there is an inverse correlation between nitrite levels in the blood and ADP-induced platelet aggregation.…”
Section: Discussionmentioning
confidence: 99%
“…Along with hypoperfusion, BD leads to the activation of the inflammatory pathways and reduction in hormone synthesis and release [9,13]. BD‐generated inflammatory response is higher in female animals, occurring in parallel with the acute reduction in female sex hormone concentration [12,13].…”
Section: Discussionmentioning
confidence: 99%