Sex-related differences in stressful events precipitating transient global amnesia – A retrospective observational study

Hoyer, Carolin; Ebert, Anne; Sandikci, Vesile; Platten, Michael; Szabo, Kristina

doi:10.1016/j.jns.2021.117464

Cited by 10 publications

(14 citation statements)

References 24 publications

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“…Quinette et al found a different profile of precipitating events between the sexes: in men, the TGA episode occurred more frequently after a strenuous physical event, whereas, in women, TGA was often precipitated by an emotional event [12]. The same sex-related differences in the precipitating event profile were found in a recent retrospective observational analysis of 389 patients with TGA [28]. In this study, emotional triggers were experienced more often by women (37.2% vs. 22.8%, p = 0.003), while physical stressors were more frequent in men (30.7% vs. 41.1%), p = 0.035).…”

Section: Precipitating Eventsmentioning

confidence: 87%

“…Information about precipitating events and the beginning of the attack should be available from a capable observer who witnessed the onset (Table 1). Unspecified [6,7,10,12,20,[26][27][28].…”

Section: Precipitating Eventsmentioning

confidence: 99%

“…Documented TGA attacks are preceded in 50–90% of cases by precipitating events that may be divided into the following classes: Emotional stress, (i.e., triggered by medical procedures, interpersonal conflict, birth/death announcement, and difficult/exhausting workday); Physical effort, (i.e., gardening, housework, and sawing wood); Acute pain; Water contact/temperature change, (i.e., hot bath/shower and cold swim); Sexual intercourse; Valsalva-associated maneuvers; Unspecified [ 6 , 7 , 10 , 12 , 20 , 26 , 27 , 28 ]. …”

Section: Tga Roadmapmentioning

confidence: 99%

“…In this study, emotional triggers were experienced more often by women (37.2% vs. 22.8%, p = 0.003), while physical stressors were more frequent in men (30.7% vs. 41.1%), p = 0.035). In the same study, the emotional trigger was often classified as interpersonal conflict (42.7%) [ 28 ]. However, emotional and psychological distress are frequent precipitating events in patients with TGA and are often associated with phobic personality traits [ 4 , 12 , 24 , 27 , 30 ].…”

Section: Tga Roadmapmentioning

confidence: 99%

See 3 more Smart Citations

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

Sparaco

Pascarella

Muccio

et al. 2022

JCM

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Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of a temporary memory disorder with profound anterograde amnesia and a variable impairment of the past memory. Usually, the attacks are preceded by a precipitating event, last up to 24 h and are not associated with other neurological deficits. Diagnosis can be challenging because the identification of TGA requires the exclusion of some acute amnestic syndromes that occur in emergency situations and share structural or functional alterations of memory circuits. Magnetic Resonance Imaging (MRI) studies performed 24–96 h after symptom onset can help to confirm the diagnosis by identifying lesions in the CA1 field of the hippocampal cornu ammonis, but their practical utility in changing the management of patients is a matter of discussion. In this review, we aim to provide a practical approach to early recognition of this condition in daily practice, highlighting both the lights and the shadows of the diagnostic criteria. For this purpose, we summarize current knowledge about the clinical presentation, diagnostic pathways, differential diagnosis, and the expected long-term outcome of TGA.

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Section: Precipitating Eventsmentioning

confidence: 87%

Section: Precipitating Eventsmentioning

confidence: 99%

Section: Tga Roadmapmentioning

confidence: 99%

Section: Tga Roadmapmentioning

confidence: 99%

See 2 more Smart Citations

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

Sparaco

Pascarella

Muccio

et al. 2022

JCM

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“…The observed psychological, neuroanatomical and hormonal sex differences in episodic memory suggest a role in sex differences with regard to dysfunctional performance, for example, in TGA. A recently published retrospective observational study showed a predominance of females regarding the incidence of TGA and a sex-specific difference in various precipitating events in TGA patients, with more emotional triggers in females and more physical triggers in males [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Transient Global Amnesia (TGA): Sex-Specific Differences in Blood Pressure and Cerebral Microangiopathy in Patients with TGA

Rogalewski

Beyer

Friedrich

et al. 2022

JCM

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Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear aetiology for a period of less than 24 h. Observed psychological, neuroanatomical and hormonal differences between the sexes in episodic memory suggest sex-specific differences in memory disorders such as TGA. The aim of this study was to determine sex-specific differences in cardiovascular risk profiles, recurrences and magnetic resonance imaging (MRI). In total, 372 hospitalised TGA patients between 01/2011 and 10/2021 were retrospectively analysed. Comparisons were made between female and male TGA patients and compared to 216 patients with acute stroke. In our sample, women were overrepresented (61.8%), especially compared to the general population in the 65–74 age category (χ2 = 10.6, p < 0.02). On admission, female TGA patients had significantly higher systolic blood pressure values and a higher degree of cerebral microangiopathy compared to male TGA patients, whereas acute stroke patients did not. No sex-specific differences were observed with respect to recurrences or hippocampal DWI lesions. Our data demonstrate sex-specific differences in TGA. The higher blood pressure on admission and different degree of cerebral microangiopathy in female TGA patients supports the theory of blood pressure dysregulation as a disease trigger. Distinct precipitating events in female and male patients could lead to differences in the severity and duration of blood pressure abnormalities, possibly explaining the higher incidence in female patients.

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Simultaneous occurrence of transient global amnesia and Takotsubo syndrome triggered by caring for a terminally ill relative

Stöllberger,

Finsterer

2024

Clinical Case Reports

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Sex-related differences in stressful events precipitating transient global amnesia – A retrospective observational study

Cited by 10 publications

References 24 publications

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map

Transient Global Amnesia (TGA): Sex-Specific Differences in Blood Pressure and Cerebral Microangiopathy in Patients with TGA

Simultaneous occurrence of transient global amnesia and Takotsubo syndrome triggered by caring for a terminally ill relative

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