Sex-related disparities in obstructive coronary artery disease, percutaneous coronary intervention, and mortality in adults with cardiac arrest

John, Jenine E.; Parikh, Puja B.; Thippeswamy, Ganesh; Kataya, Abdo; Loeb, Charles; Tran, Laurie; Patel, Jignesh

doi:10.1016/j.ijcard.2018.07.125

Cited by 9 publications

(10 citation statements)

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“…Several studies have demonstrated differences in angiographic outcomes between men and women in OHCA. 14,18 As men have a significantly higher prevalence of obstructive CAD, one would expect that in men, ischemic heart disease is more frequently the cause of the arrest, and Fig. 3 -Assessment of effect modification of associations between treatment and risk factors and one-year survival by sex.…”

Section: Discussionmentioning

confidence: 99%

“…3,11 In recent years, sex differences in patients with OHCA are being increasingly recognized in both pathophysiology and treatment of CAD. 12,13,14,15 Studies including cardiac arrest patients with all initial rhythms and presumed cardiac aetiology have shown that almost 80% of patients are male 12,14,16,17,18 and that cardiac arrest due to an initial shockable rhythm is more common in men than women. 12,15,17,18,19 If women suffer from OHCA, they are often older 15,17,19,20 , and have a higher cardiovascular risk profile than men.…”

mentioning

confidence: 99%

“…12,13,14,15 Studies including cardiac arrest patients with all initial rhythms and presumed cardiac aetiology have shown that almost 80% of patients are male 12,14,16,17,18 and that cardiac arrest due to an initial shockable rhythm is more common in men than women. 12,15,17,18,19 If women suffer from OHCA, they are often older 15,17,19,20 , and have a higher cardiovascular risk profile than men. 12,19 Present data on the association between sex and OHCA-related survival is mainly based on national registries containing a heterogeneous patient population.…”

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confidence: 99%

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Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

et al. 2021

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Background: Whether sex is associated with outcomes of out-of-hospital cardiac arrest (OHCA) is unclear.Objectives: This study examined sex differences in survival in patients with OHCA without ST-segment elevation myocardial infarction (STEMI).Methods: Using data from the randomized controlled Coronary Angiography after Cardiac Arrest (COACT) trial, the primary point of interest was sex differences in OHCA-related one-year survival. Secondary points of interest included the benefit of immediate coronary angiography compared to delayed angiography until after neurologic recovery, angiographic and clinical outcomes.Results: In total, 522 patients (79.1% men) were included. Overall one-year survival was 59.6% in women and 63.4% in men (HR 1.18; 95% CI: 0.76-1.81;p = 0.47). No cardiovascular risk factors were found that modified survival. Women less often had significant coronary artery disease (CAD) (37.0% vs. 71.3%;p < 0.001), but when present, they had a worse prognosis than women without CAD (HR 3.06; 95% CI 1.31À7.19;p = 0.01). This was not the case for men (HR 1.05; 95% CI 0.67À1.65;p = 0.83). In both sexes, immediate coronary angiography did not improve one-year survival compared to delayed angiography (women, odds ratio (OR) 0.87; 95% CI 0.58À1.30;p = 0.49; vs. men, OR 0.97; 95% CI 0.45À2.09;p = 0.93). Conclusion:In OHCA patients without STEMI, we found no sex differences in overall one-year survival. Women less often had significant CAD, but when CAD was present they had worse survival than women without CAD. This was not the case for men. Both sexes did not benefit from a strategy of immediate coronary angiography as compared to delayed strategy with respect to one-year survival.Clinical trial registration number: Netherlands trial register (NTR) 4973.

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Section: Discussionmentioning

confidence: 99%

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Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

et al. 2021

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“…With the rapid economic development, changes in lifestyles, and adoption of unhealthy diet, coronary artery disease (CAD) has become a major problem worldwide and the leading global cause of mortality in recent years. [ 1 – 3 ] Percutaneous coronary intervention (PCI) is a primary and common treatment method for CAD. [ 4 ] PCI can dilate stenotic or obstructed coronary artery, relieve clinical symptoms, and decrease mortality from CAD.…”

Section: Introductionmentioning

confidence: 99%

Effect of trimetazidine on incidence of major adverse cardiac events in coronary artery disease patients undergoing percutaneous coronary intervention

Zhu¹,

Zheng²,

Fang³

2020

Medicine

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Background: Percutaneous coronary intervention (PCI) is a common treatment method for coronary artery disease (CAD). PCI can cause myocardial ischemia or injury, and lead to major adverse cardiac events (MACEs). Trimetazidine has significant cardioprotective effects and improves endothelial dysfunction and myocardial injury. We will conduct a comprehensive systematic review and meta-analysis to evaluate effect of trimetazidine on incidence of MACE in CAD patients undergoing PCI. Methods: PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and China Science and Technology Journal Database will be searched to collect randomized controlled trials (RCTs) of trimetazidine for CAD patients undergoing PCI. The range of publication time will be from the inception of the database to October 2020 without language limitation. Two reviewers will independently conduct study selection, data extraction and management, and assessment of risk of bias. Any disagreement will be resolved by discussion with the third reviewer. Review Manager Software 5.3 will be used for meta-analysis. The Cochrane risk of bias tool will be used to assess the risk of bias. Results: This study will provide a systematic synthesis of current published data to summarize the effect of trimetazidine on incidence of MACE such as stent restenosis, stent thrombosis, new significant coronary stenosis, myocardial infarction, heart failure, and cardiac arrest in CAD patients undergoing PCI. Conclusions: This meta-analysis will provide evidence as to whether trimetazidine can reduce incidence of MACE in CAD patients undergoing PCI. Study registration number: INPLASY202090083.

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“…Coronary heart diseases are the most common cause of morbidity and mortality among cardiovascular diseases [Sayols-Baixeras 2014;John 2018;Mahonen 2000]. Their incidence rate is 181.4 in every 100,000 individuals, with 46% of mortality cases [Boroumand 2016].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Text Message On Self-Management for Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials

Wan

Kou

2020

HSF

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Introduction: The influence of text message on self-management for coronary heart disease remains controversial. We conducted a systematic review and meta-analysis to explore the impact of text message versus usual care on self-management for coronary heart disease. Methods: We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through July 2018 for randomized controlled trials (RCTs), assessing the effect of text message versus usual care on self-management for coronary heart disease. This meta-analysis is performed using the random-effect model. Results: Six RCTs involving 1,158 patients are included in the meta-analysis. Overall, compared with a control group for coronary heart disease, text message intervention has no substantial influence on self-efficacy (Std. MD = 2.37; 95% CI = -2.61 to 7.35; P = .35), LDL (Std. MD = -1.81; 95% CI = -4.80 to 1.18; P = .24), HDL (Std. MD = -1.15; 95% CI = -2.83 to 0.54; P = .18), BMI (Std. MD = -3.61; 95% CI = -9.48 to 2.26; P = .23), systolic blood pressure (Std. MD = -3.46; 95% CI = -9.03 to 2.12; P = .22), diastolic blood pressure (Std. MD = -2.03; 95% CI = -5.90 to 1.85; P = .31, non-smoker (RR = 1.12; 95% CI = 0.78 to 1.62; P = .53), and physical activity (RR = 1.57; 95% CI = 0.63 to 3.90; P = .33). Conclusions: Text message intervention demonstrates no positive impact on self-efficacy, treatment adherence, and the control of risk factors in patients with coronary heart disease.

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Sex-related disparities in obstructive coronary artery disease, percutaneous coronary intervention, and mortality in adults with cardiac arrest

Cited by 9 publications

References 30 publications

Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation: A COACT trial substudy

Effect of trimetazidine on incidence of major adverse cardiac events in coronary artery disease patients undergoing percutaneous coronary intervention

The Impact of Text Message On Self-Management for Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials

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