2019
DOI: 10.1002/mds.27725
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Sex‐related pattern of intrinsic brain connectivity in drug‐naïve Parkinson's disease patients

Abstract: Background Sex difference is related to specific clinical features in PD patients over the disease course. Objectives To investigate the potential sex‐difference effect on the spontaneous neuronal activity within the most reported resting‐state networks in early untreated PD patients and its correlation with baseline and longitudinal clinical features. Methods Fifty‐six drug‐naïve PD patients (30/26 male/female) and 30 (15/15 male/female) matched controls were enrolled in the study. Topological and spectral re… Show more

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Cited by 21 publications
(23 citation statements)
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“…The study sample was recruited from an ongoing longitudinal study enrolling patients with early PD diagnosed according to the modified diagnostic criteria of the UK Parkinson's Disease Society Brain Bank 15 at the Movement Disorders Unit of the First Division of Neurology at the University of Campania “Luigi Vanvitelli” (Naples, Italy). As previously described, 16,17 patients enrolled in this longitudinal study underwent an extensive motor and nonmotor assessment (please see “Prelockdown Measures” for further details) at the time they were diagnosed with PD (timepoint 0). After the baseline assessments, patients were prospectively followed with a full clinical evaluation every year (timepoints 1, 2, 3, 4 and 5, to date).…”
Section: Methodsmentioning
confidence: 99%
“…The study sample was recruited from an ongoing longitudinal study enrolling patients with early PD diagnosed according to the modified diagnostic criteria of the UK Parkinson's Disease Society Brain Bank 15 at the Movement Disorders Unit of the First Division of Neurology at the University of Campania “Luigi Vanvitelli” (Naples, Italy). As previously described, 16,17 patients enrolled in this longitudinal study underwent an extensive motor and nonmotor assessment (please see “Prelockdown Measures” for further details) at the time they were diagnosed with PD (timepoint 0). After the baseline assessments, patients were prospectively followed with a full clinical evaluation every year (timepoints 1, 2, 3, 4 and 5, to date).…”
Section: Methodsmentioning
confidence: 99%
“…All patients underwent a detailed neurological and neuropsychological assessment as previously reported [22][23][24] (see Appendix S1 for more details).…”
Section: Neurological and Neuropsychological Assessmentmentioning
confidence: 99%
“…The variability of FC in healthy older adults found strongest correlate of FC in the BGN, and potential links to dopamine-related function ( Griffanti et al, 2018 ). A sex-related pattern of RSN showed an increased connectivity within the BGN in female PD patients, and FC changes in sensorimotor at baseline were considered as an independent predictor of disease severity in the early stage of PD ( De Micco et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%