Sex-related variations in bone microstructure of rabbits intramuscularly exposed to patulin

Ďúranová, Hana; Kováčová, Veronika; Babošová, Ramona; Omelka, Radoslav; Adamkovičová, Mária; Großkopf, Birgit; Capcarová, Marcela; Martiniaková, Monika

doi:10.1186/s13028-015-0140-0

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…A study performed on adult rabbits showed a significant impact of the mycotoxin on bone microstructure ( 7 ). Acute or chronic exposure of pregnant mothers to DON shows foetotoxic effects evidenced by skeletal ossification decrease and delayed foetal development ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

DON-induced changes in bone homeostasis in mink dams

Tomaszewska

Dobrowolski

Muszyński

et al. 2017

Journal of Veterinary Research

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IntroductionThe aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting.Material and MethodsThirty clinically healthy multiparous minks (Neovison vison) of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: non-treated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg-1 of feed. Results The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties.ConclusionDON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone.

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Section: Introductionmentioning

confidence: 99%

DON-induced changes in bone homeostasis in mink dams

Tomaszewska

Dobrowolski

Muszyński

et al. 2017

Journal of Veterinary Research

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“…Rabbits display less cancellous bone than humans . They have more fragile cortices . Cortical thickness and the diameter of drilled holes contribute to the high complication rate of fracture repair in this species .…”

Section: Rabbits In Bone Research: Where Are We?mentioning

confidence: 99%

Animal modeling in bone research—Should we follow the White Rabbit?

Macedo

Feitosa

Kawamoto

et al. 2019

Anim Models and Exp Med

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In the long history of mankind, animals have played significant roles.We owe much of our intellectual sophistication and societal status to animal husbandry. 1 Farming and agriculture have allowed humans to control their environment and an improved nutrition. The first rural settlements marked the birth of the ancient civilizations, 2 but also triggered the first zoonotic outbreaks and the beginning of public health concerns. 3 The earliest records of animal use coincide with the appearance of Hippocrates' concepts and the birth of Western medicine. 2 Jumping ahead 2400 years, in the year 2018 more than 20 000 animal subjects-exceeding 200 species-were part of translational studies worldwide, 4 in pre-clinical trials. 2 Animal modelling can provide reliable data to elucidate human diseases. 5 Despite benefiting our quality of life, animal research remains controversial. 3 There is a growing sense of disapproval over using household pets in experiments. 1 New technologies have been created to replace animals in research, but the position of ideal bone substitute remains open. 6 Thus, primary research on novel models continues paramount. 7 AbstractAnimal models are live subjects applied to translational research. They provide insights into human diseases and enhance biomedical knowledge. Livestock production has favored the pace of human social development over millennia. Today's society is more aware of animal welfare than past generations. The general public has marked objections to animal research and many species are falling into disuse. The search for an ideal methodology to replace animal use is on, but animal modeling still holds great importance to human health. Bone research, in particular, has unmet requirements that in vitro technologies cannot yet fully address. In that sense, standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models. Our aim here is to provide a broad overview of animal modeling and its ethical implications, followed by a narrower focus on bone research and the role rabbits are playing in the current scenario. K E Y W O R D Sanimal experimentation, bone density, Lagomorpha, translational medical research MACEDO Et Al.

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