Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity

Kosten, Therese A.; Miserendino, Mindy J.D.; Bombace, Joan C.; Lee, Hongjoo J.; Kim, Jeansok J.

doi:10.1016/j.bbr.2004.07.001

Cited by 87 publications

(85 citation statements)

References 64 publications

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“…We have consistently shown that baseline activity levels do not differ between ISO and NH rats (Kehoe et al, 1996(Kehoe et al, , 1998bKosten et al, 2000Kosten et al, , 2004Kosten et al, , 2005a. There are also no group differences in inactive lever press responses in the self-administration study and no differences in baseline response rates in the food study.…”

Section: Discussionmentioning

confidence: 50%

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Kosten

Zhang

Kehoe

2005

Neuropsychopharmacol

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Previously, we demonstrated that the early life stress of neonatal isolation facilitates acquisition of cocaine and food self-administration in adult female rats. We now test whether it enhances responding for these reinforcers after operant performance is established. Adult female rats were derived from litters that were either subjected to neonatal isolation (1 h/day isolation; postnatal days 2-9) or were nonhandled and assigned to one of two experiments. In Experiment 1, female rats well trained to self-administer cocaine were tested under a fixed-ratio 3 (FR3) schedule with several cocaine doses (0.0625-1.0 mg/kg/infusion) and under a progressive-ratio (PR) schedule (0, 0.5, and 1.0 mg/kg/infusion cocaine). In Experiment 2, female rats well trained to respond for food reinforcers under an FR15 schedule were tested under two PR schedules. Results show that neonatal isolation enhanced responding for cocaine under both schedules of reinforcement and increased responding for food under a PR schedule of reinforcement. These data extend our previous acquisition study in female rats to show that neonatal isolation enhances responding under maintenance conditions. These enduring behavioral changes may relate to the ability of neonatal isolation to increase striatal dopamine responses to psychostimulants, effects we showed previously in infant and juvenile rats.

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Section: Discussionmentioning

confidence: 50%

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Kosten

Zhang

Kehoe

2005

Neuropsychopharmacol

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“…Kosten et al (2005) demonstrated that rats exposed to neonatal isolation show increased USV responses to footshock stress. In addition, rats exposed to neonatal ventral hippocampal lesion display an attenuated increase in plasma corticosterone levels as compared with sham-lesion controls after 20 min of footshock, and this response fails to adapt after 60 min of footshock (Chrapusta et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Stress Responsivity in a Rodent Developmental Disruption Model of Schizophrenia

Zimmerman

Bellaire

Ewing

et al. 2013

Neuropsychopharmacol

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Although numerous studies have implicated stress in the pathophysiology of schizophrenia, less is known about how the effects of stress interact with genetic, developmental, and/or environmental determinants to promote disease progression. In particular, it has been proposed that in humans, stress exposure in adolescence could combine with a predisposition towards increased stress sensitivity, leading to prodromal symptoms and eventually psychosis. However, the neurobiological substrates for this interaction are not fully characterized. Previous work in our lab has demonstrated that rats born to dams administered with the DNA-methylating agent methylazoxymethanol acetate (MAM) at gestational day 17 exhibit as adults behavioral and anatomical abnormalities consistent with those observed in patients with schizophrenia. Here, we examined behavioral and neuroendocrine responses to stress in the MAM model of schizophrenia. MAM-treated male rats were exposed to acute and repeated footshock stress at prepubertal, peripubteral, and adult ages. Ultrasonic vocalizations (USVs), freezing, and corticosterone responses were quantified. We found that juvenile MAM-treated rats emitted significantly more calls, spent more time vocalizing, emitted calls at a higher rate, and showed more freezing in response to acute footshock stress when compared with their saline (SAL) treated counterparts, and that this difference is not present in older animals. In addition, adolescent MAM-treated animals displayed a blunted HPA axis corticosterone response to acute footshock that did not adapt after 10 days of stress exposure. These data demonstrate abnormal stress responsivity in the MAM model of schizophrenia and suggest that these animals are more sensitive to the effects of stress in youth.

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Section: Sex Differences In Animal Models Of Ptsdmentioning

confidence: 98%

“…In contextual fear conditioning, female rats show less learned freezing behaviour than male rats (Maren et al, 1994;Pryce et al, 1999). In cue fear conditioning, male rats again exhibit more conditioned fear than female rats, either when freezing or when ultrasonic vocalizations are used as a CR (Maren et al, 1994;Pryce et al, 1999;Kosten et al, 2005).It has been proposed that PTSD patients show reduced extinction of the fear induced by the traumatic experience (Milad et al, 2006;2008;Rauch et al, 2006). In animals, extinction can be assessed by exposing them repeatedly to the CS without the US and observe the reduction of the CR.…”

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confidence: 99%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

359

187

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Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

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Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity

Cited by 87 publications

References 64 publications

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Abnormal Stress Responsivity in a Rodent Developmental Disruption Model of Schizophrenia

Sex differences in animal models of psychiatric disorders

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