Sex-Specific Alterations of White Matter Developmental Trajectories in Infants With Prenatal Exposure to Methamphetamine and Tobacco

Chang, Linda; Oishi, Kenichi; Skranes, Jon; Buchthal, Steven; Cunningham, Eric; Yamakawa, Robyn; Hayama, Sara; Jiang, Caroline S.; Alicata, Daniel; Hernandez, Antonette; Cloak, Christine; Wright, Tricia E.; Ernst, Thomas

doi:10.1001/jamapsychiatry.2016.2794

Cited by 45 publications

(66 citation statements)

References 66 publications

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“…Methamphetamine is known to cross the fetal blood–brain barrier, leading to the accumulation of dopamine in synapses via reuptake blockade, and damage of neural terminals and synapses in offspring (Jablonski, Williams, & Vorhees, ; Jeng, Wong, Ting‐A‐Kee, & Wells, ). Brain imaging studies have found that prenatal methamphetamine exposure (PME) is associated with structural and functional alterations of striatal, frontal, parietal, and limbic regions in children, as well as changes to structural connectivity of such regions in infants (Chang et al, ; Kwiatkowski, Roos, Stein, Thomas, & Donald, ; Warton, Meintjes, et al, ; Warton, Taylor, et al, ). These regions underlie learning ability, sensorimotor, and executive function, as well as behavioral and emotional regulation.…”

Section: Introductionmentioning

confidence: 99%

Structural brain network development in children following prenatal methamphetamine exposure

Roos

Fouché

Toit

et al. 2020

J of Comparative Neurology

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Brain imaging studies in children with prenatal methamphetamine exposure (PME) suggest structural and functional alterations of striatal, frontal, parietal, and limbic regions. However, no longitudinal studies have investigated changes in structural connectivity during the first 2 years of formal schooling. The aim of this study was to explore the effects of PME on structural connectivity of brain networks in children over the critical first 2 years of formal schooling when foundational learning takes place. Networks are expected to gradually increase in global connectedness while segregating into defined systems. Graph theoretical analysis was used to investigate changes in structural connectivity at age 6 and 8 years in children with and without PME. While healthy control children showed increased connectivity in frontal and limbic hubs over time, children with PME showed increased connectivity in the superior parietal cortex and striatum in their global network. Furthermore, compared to control children, those with PME were characterized by less change in segregation of structural networks over time. These findings are consistent with previous work on regions implicated in children with PME, but they additionally demonstrate alterations in structural connectivity between regions that underlie primary cognitive, behavioral, and emotional development. Understanding patterns of network development during critical periods in at-risk children may inform strategies for supporting this group of children in these developmental tasks important for lifelong brain health and development.

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Section: Introductionmentioning

confidence: 99%

Structural brain network development in children following prenatal methamphetamine exposure

Roos

Fouché

Toit

et al. 2020

J of Comparative Neurology

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“…One such study by Chang et al (2016) of age, which is intriguing considering that prenatal cigarette smoking exposure has been reported to lead to undesirable outcomes in later life (Müller et al, 2013;Weissman, Warner, Wickramaratne, & Kandel, 1999). One such study by Chang et al (2016) of age, which is intriguing considering that prenatal cigarette smoking exposure has been reported to lead to undesirable outcomes in later life (Müller et al, 2013;Weissman, Warner, Wickramaratne, & Kandel, 1999).…”

Section: Tobacco and Drugs Of Abuse As Prenatal Exposuresmentioning

confidence: 99%

“…Studies with repeated scans are especially informative, partly because some of the observed structural changes may disappear, even if the functional effects of the exposure remain. One such study by Chang et al (2016) examined the effects of prenatal methamphetamine and tobacco exposures, performing repeated scans during the first 6 months of life. Sex-dependent variations in fractional anisotropy (FA) and diffusivity values were seen widely in the corona radiata.…”

Section: Tobacco and Drugs Of Abuse As Prenatal Exposuresmentioning

confidence: 99%

“…In summary, many studies did not report the use of alcohol, tobacco, or illicit drugs during pregnancy (Table 2). To avoid unreliable results, prenatal exposure to any drugs of abuse should either be used as a reason for exclusion or examined in detail, for example, by reporting the number of users, the amount of substance used, and the number of trimesters with any exposure, as in Chang et al (2016). One study (May et al, 2013) compared the number of drinks used by mothers of children with different fetal alcohol spectrum disorders to mothers of normally developing controls with and without PAE.…”

Section: Chemical Exposuresmentioning

confidence: 99%

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Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis

Pulli

Kumpulainen

Kasurinen

et al. 2018

Human Brain Mapping

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Brain development is most rapid during the fetal period and the first years of life. This process can be affected by many in utero factors, such as chemical exposures and maternal health characteristics. The goal of this review is twofold: to review the most recent findings on the effects of these prenatal factors on the developing brain and to qualitatively assess how those factors were generally reported in studies on infants up to 2 years of age. To capture the latest findings in the field, we searched articles from PubMed 2012 onward with search terms referring to magnetic resonance imaging (MRI), brain development, and infancy. We identified 19 MRI studies focusing on the effects of prenatal environment and summarized them to highlight the recent advances in the field. We assessed population descriptions in a representative sample of 67 studies and conclude that prenatal factors that have been shown to affect brain metrics are not generally reported comprehensively. Based on our findings, we propose some improvements for population descriptions to account for plausible confounders and in time enable reliable meta‐analyses to be performed. This could help the pediatric neuroimaging field move toward more reliable identification of biomarkers for developmental outcomes and to better decipher the nuances of normal and abnormal brain development.

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“…107 After that study prenatal methamphetamine has been associated with reduced regional brain volumes linked to attention processing deficits, 108 altered brain activation patterns (fMRI), 109 and recently alterations in white matter developmental trajectories (DTI). 110 For cocaine-exposed children a variety of gross structural abnormalities were reported in early imaging studies. 106 More recent studies have reported subtle changes, like alterations of regional patterns of striatal morphology in prenatally cocaine-exposed adolescents.…”

Section: Mri Studies Of Prenatally Drug-exposed Childrenmentioning

confidence: 99%

Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

Sirnes

Elgen

Chong

et al. 2016

Clin Pediatr (Phila)

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This study aimed to evaluate cerebral magnetic resonance imaging (MRI) scans of children with prenatal drug exposure in a clinical context. A hospital-based cohort of 10- to 14-year-old children, prenatally exposed to alcohol, opioids, and polysubstances, and a group of sex- and age-matched controls were examined with cerebral MRI. Scans obtained from 34 exposed children and 40 controls were scored based on the presence and degree of pathology by an experienced pediatric neuroradiologist blinded to the participants’ background. Overall visual detectable MRI pathology was found in 35% of the exposed children and 33% of the controls (odds ratio = 1.08; 95% confidence interval = 0.36-3.25). No specific imaging pattern following prenatal drug exposure was seen by the means of simple visual analysis of cerebral MRI scans. Although cerebral MRI is feasible, it is probably of limited value in the clinical assessment of children with prenatal drug exposure.

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Sex-Specific Alterations of White Matter Developmental Trajectories in Infants With Prenatal Exposure to Methamphetamine and Tobacco

Cited by 45 publications

References 66 publications

Structural brain network development in children following prenatal methamphetamine exposure

Structural brain network development in children following prenatal methamphetamine exposure

Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis

Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

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