Sex-specific association between asthma and hypertension in nationally representative young Korean adults

Lee, Hong Seok; Park, Young Jun; Han, Kyungdo; Pekler, Gerald; Lee, Seongsu; Yoo, Soon‐Jib; Kim, Dae Jung

doi:10.1038/s41598-017-15722-w

Cited by 8 publications

(9 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 There have been studies on the associations between predominantly adult asthma and NCDs diagnosed in adults, but some did not establish temporality due to their inability to ascertain the ages of asthma and NCD diagnoses, 11,17,18 and few have examined effect of modification by sex. 11,12,19 These studies found that asthmatics had increased risks of hypertension at 18-75 years of age, 17 with diabetes diagnosed later in adulthood. 21 Future studies will be needed to further understand the associations between asthma and different phenotypes of diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…an Italian study (which cross-sectionally analyzed those diagnosed with asthma and other NCDs at 14+ years of age) found that ever diagnosis with asthma was significantly associated with hypertension in women, but not in men. 11,19 However, both of these studies had the limitation of having no temporality. Other explanations for the Several mechanisms may explain our findings.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between pediatric asthma and adult non‐communicable diseases

Juber¹,

Lee

Pan³

et al. 2020

Pediatric Allergy Immunology

View full text Add to dashboard Cite

Background To date, there is no comprehensive study examining how asthma diagnosed in childhood or adolescence is associated with diagnoses of subsequent non‐communicable diseases (NCDs) during adulthood. Our study aimed to examine the associations between pediatric asthma and several adult NCDs, with temporality and long interval times between asthma and NCD diagnoses. Methods We used RAND Indonesian Family Life Survey Fifth Wave (IFLS5) fielded in 2014‐2015, to study whether being diagnosed with pediatric asthma at 0‐19 years of age was associated with increased risks of hypertension, diabetes, rheumatoid arthritis, stomach diseases, kidney diseases, and heart diseases or stroke diagnosed in adulthood. We used the weighted Poisson regression adjusting for age, sex, urbanicity, and insurance status to estimate risk ratios. Subgroup analyses were performed by sex and age of asthma and other NCD diagnoses. Results Pediatric asthma significantly increased risks of hypertension, diabetes, and stomach diseases diagnosed at 20 years of age or above. Males with pediatric asthma diagnosed at 0‐10 years of age had significantly higher risk of hypertension, while females with pediatric asthma diagnosed at 0‐10 years of age had significantly higher risks of diabetes and stomach diseases. Females with pediatric asthma diagnosed at 11‐19 years of age had significantly higher risks of diabetes, arthritis, stomach diseases, and kidney diseases. We also found varying associations by age of NCD diagnosis. Conclusion Our results suggest pediatric asthma is associated with increased risks of several adult NCDs, and these associations may vary by sex and age of asthma and other NCD diagnoses.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations between pediatric asthma and adult non‐communicable diseases

Juber¹,

Lee

Pan³

et al. 2020

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…Sex differences related to immune disorders have also been shown previously [ 39 ]. Diabetes type 1 [ 40 ], asthma [ 41 , 42 ], hypertensive disease [ 42 ] and inflammatory bowel disease [ 43 ] mostly affect males more than females. A male disadvantage in immune responses to infectious diseases [ 44 ] and outcome after sepsis [ 45 ] has also been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Surge of immune cell formation at birth differs by mode of delivery and infant characteristics—A population-based cohort study

et al. 2017

View full text Add to dashboard Cite

BackgroundBirth by cesarean section is associated with increased risks of immune disorders. We tested whether establishment of immune function at birth relates to mode of delivery, taking other maternal and infant characteristics into account.Methods and findingsUsing a prospectively collected database, we retrieved information on maternal and infant characteristics of 6,014 singleton infants delivered from February to April 2014 in Stockholm, Sweden, with gestational age ≥35 weeks, Apgar scores ≥7, and without congenital malformations or any neonatal morbidity. We linked our data to blood levels of T-cell receptor excision circles (TREC) and κ-deleting recombination excision circles (KREC), determined as part of a neonatal screening program for immune-deficiencies, and representing quantities of newly formed T- and B-lymphocytes. Multivariate logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for participants having TREC and KREC levels in the lowest quintile. Multivariate models were adjusted for postnatal age at blood sampling, and included perinatal (mode of delivery, infant sex, gestational age, and birth weight for gestational age), and maternal characteristics (age, parity, BMI, smoking, diabetes, and hypertensive disease).Low TREC was associated with cesarean section before labor (adjusted OR:1.32 [95% CI 1.08–1.62]), male infant sex (aOR:1.60 [1.41–1.83]), preterm birth at 35–36 weeks of gestation (aOR:1.89 [1.21–2.96]) and small for gestational age (aOR:1.67 [1.00–2.79]). Low KREC was associated with male sex (aOR:1.32 [1.15–1.50]), postterm birth at ≥42 weeks (aOR:1.43 [1.13–1.82]) and small for gestational age (aOR:2.89 [1.78–4.69]). Maternal characteristics showed no consistent associations with neonatal levels of either TREC or KREC.ConclusionCesarean section before labor was associated with lower T-lymphocyte formation, irrespective of maternal characteristics, pregnancy, and neonatal risk factors. The significance of a reduced birth-related surge in lymphocyte formation for future immune function and health remains to be investigated.

show abstract

“…Females are reported to generate significantly higher levels of protective antibodies and cellmediated immunity following viral vaccinations against measles, rubella, rabies, smallpox, dengue, mumps, influenza, yellow fever, and hepatitis A and B (7)(8)(9). However, there are clearly complexities as other studies have reported that the incidence of immune-associated conditions such as asthma (10) and type 1 diabetes (11) is considerably higher in males than in females. These differences are likely to be attributable, at least in part, to sex steroids which can bind to immune-associated cells and impact on their function (2), but also to non-endocrine-related genes since significant numbers of immune-associated genes are located on the X chromosome (12).…”

Section: Introductionmentioning

confidence: 98%