Sex-Specific Association of Tinnitus With Suicide Attempts

Lugo, Alessandra; Trpchevska, Natalia; Liu, Xiaoqiu; Biswas, Roshni; Magnusson, Cecilia; Gallus, Silvano; Cederroth, Christopher R.

doi:10.1001/jamaoto.2019.0566

Cited by 41 publications

(56 citation statements)

References 7 publications

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“…Yet, there was a distinct gender effect for the assessed psychological comorbidities, with women reporting higher anxiety, depression and worries than men. These gender effects are consistent with previous studies, who also found higher anxiety and depression (Gallus et al, 2015;Pattyn et al, 2016;Bashir et al, 2017;Strumila et al, 2017;Ziai et al, 2017), as well as higher level of distress (Seydel et al, 2013) and increased likelihood for suicide attempts (Lugo et al, 2019) in women.…”

Section: Discussionsupporting

confidence: 92%

“…While Gallus et al (2015) found no overall sex differences regarding the prevalence of (chronic) tinnitus, severe levels of tinnitus distress were more frequent in women. Lugo et al (2019) reported in a cross -sectional study a sex-dependent association of tinnitus with suicide attempts, with severe tinnitus associated with suicide attempts in women but not in men. Furthermore, women reported more tinnitus complaints then men.…”

Section: Introductionmentioning

confidence: 98%

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Gender Comparison of Psychological Comorbidities in Tinnitus Patients – Results of a Cross-Sectional Study

et al. 2020

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Background: In the last decades, research focused on gender-related features in patients with tinnitus has often led to controversial results. The complex clinical picture of tinnitus patients often consists of an interdependent relationship between audiological symptoms and co-occurrent psychological disorders, which can complicate the diagnostic evaluation. Methods: Therefore, we studied 107 patients with tinnitus, investigating their psychological comorbidities in the light of gender differences. All patients were evaluated with ENT/audiological and psychological examination to consider presence/absence, type and gender distribution of psychopathological comorbidities. Patients completed questionnaires on tinnitus distress (Tinnitus Handicap Inventory, THI), anxiety (Beck Anxiety Inventory, BAI), depression (Beck Depression Inventory, BDI), metacognition (Metacognition Questionnaire-30, MCQ-30) and worry (Penn State Worry Questionnaire). The influence of gender on the relationship between tinnitus distress and psychological comorbidities was investigated with simple moderation analyses using the SPSS PROCESS macro. Results: The total sample included 65 male and 42 female patients (60.7 vs. 39.3%), matched for age and duration of tinnitus. We found no significant differences for tinnitus distress (THI total score, THI subscales) and MCQ-30 subscales, except for the control over thoughts, where men showed significantly higher scores than women (p = 0.045). Also, in our sample women showed significantly higher values for depression (BDI total score, p = 0.019), anxiety (BAI total score, p = 0.010) and worries (PSQW total score, p = 0.015). Moderation analyses revealed a significant influence of gender on the relationship of tinnitus distress with depression: higher scores of tinnitus distress were associated with significantly elevated levels of depression amongst men. No further gender influences could be observed in our sample. Discussion: In conclusion, our results indicate general gender differences for psychological comorbidities in tinnitus patients, with women reporting more depression, anxiety and worries. Men, on the other hand, showed a higher need to control their

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Gender Comparison of Psychological Comorbidities in Tinnitus Patients – Results of a Cross-Sectional Study

et al. 2020

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“…Approximately 2% of the population is extremely bothered by tinnitus [1], showing an increased risk in suicide attempts [2,3] and seeking medical support. Patients with severe tinnitus often present themselves with anxiety, depression and stress [4][5][6][7][8], thus largely affecting life quality.…”

Section: Introductionmentioning

confidence: 99%

Association between Hyperacusis and Tinnitus

Cederroth

Lugo

Edvall

et al. 2020

JCM

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Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18–90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99–4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06–10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06–20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68–14.2) for moderate and 77.4 (95% CI 35.0–171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.

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“…For instance, in some studies, women were found to exhibit higher levels of tinnitus-related distress or annoyance (Seydel et al, 2013;Gallus et al, 2015;Schlee et al, 2017), but opposite findings exist as well (Jalessi et al, 2013), and some studies found no severity differences between men and women (Axelsson and Ringdahl, 1989;Gopinath et al, 2010;Hoekstra et al, 2014). Moreover, a recent study found an association between tinnitus severity and suicide attempts in women only (Lugo et al, 2019), highlighting the importance to investigate gender differences in severe tinnitus. Differences in risk factors for bothersome tinnitus between men and women have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus

et al. 2020

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Objective: This study aims to identify gender-specific risk factors associated with the presence of bothersome tinnitus (compared with non-bothersome tinnitus), including sociodemographic and lifestyle factors, tinnitus-associated phenomena (hearing loss, traumatic experiences, sleep disturbances), and physical as well as mental comorbidities. Methods: We conducted a cross-sectional study using survey data from the Swedish LifeGene cohort containing information on self-reported tinnitus (N = 7615). We (1) analyzed risk factor and comorbidity frequencies, (2) computed multivariate logistic regression models to identify predictors of bothersome tinnitus within both genders, and (3) moderated logistic regression models to compare effects between genders. Results: (1) The majority of factors that differed in frequencies between bothersome and non-bothersome tinnitus were equal for both genders. Women with bothersome tinnitus specifically reported higher rates of cardiovascular disease, thyroid disease, epilepsy, fibromyalgia, and burnout, and men with bothersome tinnitus reported higher rates of alcohol consumption, Ménière's disease, anxiety syndrome, and panic (compared with non-bothersome tinnitus, respectively). (2) Across both genders, multivariate logistic regression analyses revealed significant associations between bothersome tinnitus and age, reduced hearing ability, hearingrelated difficulties in social situations, and reduced sleep quality. In women, bothersome tinnitus was specifically associated with cardiovascular disease and epilepsy; in men, with lower education levels and anxiety syndrome. (3) Moderated logistic regression analyses revealed that the effects of low education and anxiety syndrome were present in men, but not in women, whereas the effects of age, reduced hearing ability and related difficulties, cardiovascular disease, epilepsy, and burnout were not gender specific. Conclusion: Irrespective of gender, bothersome tinnitus is associated with higher age, reduced hearing ability, hearing-related difficulties, cardiovascular disease, epilepsy, and

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Sex-Specific Association of Tinnitus With Suicide Attempts

Cited by 41 publications

References 7 publications

Gender Comparison of Psychological Comorbidities in Tinnitus Patients – Results of a Cross-Sectional Study

Gender Comparison of Psychological Comorbidities in Tinnitus Patients – Results of a Cross-Sectional Study

Association between Hyperacusis and Tinnitus

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus

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