Sex-specific Associations Between Serum Hemoglobin Levels and the Risk of Cause-specific Death in Korea Using the National Health Insurance Service-National Health Screening Cohort (NHIS HEALS)

An, Yoonsuk; Jang, Jieun; Lee, Sangjun; Moon, Sungji; Park, Sung Sup

doi:10.3961/jpmph.19.146

Cited by 6 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are not solely risk factors for cardiovascular diseases, but also increase the risk of cancer ( 19 ). Our study applied single-factor and multivariate logistic analyses and found that CAD, cancer and combined CAD and cancer shared a common risk factor, FIB levels ( 20 , 21 ), and a common protective factor, HGB levels ( 22 , 23 ). The phenomenon that CAD and cancer possess various similarities and interactions suggests a shared biology for the two diseases.…”

Section: Discussionmentioning

confidence: 97%

Coronary Atherosclerotic Disease and Cancer: Risk Factors and Interrelation

Zhao

Lei

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundIn our clinical work, we found that cancer patients were susceptible to coronary atherosclerotic heart disease (CAD). However, less is known about the relationship between CAD and cancer. The present study aimed to identify the risk factors for CAD and cancer, as well as the relationship between CAD and cancer.MethodsIn this retrospective study, 1600 patients between January 2012 and June 2019 were enrolled and divided into groups according to whether they had CAD or cancer. Single-factor and multivariate analysis methods were applied to examine the risk factors for CAD and cancer.Results(1) Cancer prevalence was significantly higher in patients with CAD than in patients without CAD (47.2 vs. 20.9%). The prevalence of CAD in cancer and non-cancer patients was 78.9 and 52.4%, respectively. (2) Multivariable logistic regression showed that patients with cancer had a higher risk of developing CAD than non-cancer patients (OR: 2.024, 95% CI: 1.475 to 2.778, p < 0.001). Respiratory (OR: 1.981, 95% CI: 1.236–3.175, p = 0.005), digestive (OR: 1.899, 95% CI: 1.177–3.064, p = 0.009) and urogenital (OR: 3.595, 95% CI: 1.696–7.620, p = 0.001) cancers were significantly associated with a higher risk of CAD compared with no cancer. (3) Patients with CAD also had a higher risk of developing cancer than non-CAD patients (OR = 2.157, 95% CI: 1.603 to 2.902, p < 0.001). Patients in the Alanine aminotransferase (ALT) level ≥ 40 U/L group had a lower risk of cancer than patients in the ALT level < 20 U/L group (OR: 0.490, 95% CI: 0.333–0.722, p < 0.001). (4) An integrated variable (Y = 0.205 × 10–1 age − 0.595 × 10–2 HGB − 0.116 × 10–1 ALT + 0.135 FIB) was identified for monitoring the occurrence of cancer among CAD patients, with an AUC of 0.720 and clinical sensitivity/specificity of 0.617/0.711.Conclusion(1) We discovered that CAD was an independent risk factor for cancer and vice versa. (2) Digestive, respiratory and urogenital cancers were independent risk factors for CAD. (3) We created a formula for the prediction of cancer among CAD patients. (4) ALT, usually considered a risk factor, was proven to be a protective factor for cancer in this study.

show abstract

Section: Discussionmentioning

confidence: 97%

Coronary Atherosclerotic Disease and Cancer: Risk Factors and Interrelation

Zhao

Lei

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…On the other hand, dysfunctional hemoglobin may influence the oxygen transporting capacity of erythrocytes which subsequently lead to hypoxia and releasing free radicals at the inflammatory sites (31). Remarkably , the difference in hemoglobin level between the two genders is regarded to be caused by a direct stimulatory factor of androgen in males in bone marrow coupled with erythropoietin production in the kidney , and the inhibitory effect estrogen on the bone marrow in women, this action of hormones promotes hemoglobin level in males compared with females (32). Recently , it has been reported that anemia is a major public health issue that affects women (33).…”

Section: Discussionmentioning

confidence: 99%

Biochemical Role of Blood Electrolytes in Old Iraqi Patients with COVID-19

Jasim,

Samira Mouyad Yaseen2,

Hanan Adnan Shaker3

2024

J. K. Chem. Sci.

View full text Add to dashboard Cite

Background: Age progression is regarded as a critical risk factor in morbidity and mortality because of a weakened immune system. Although various studies have dealt with electrolyte imbalance in COVID-19 patients, the outcomes of these studies were partially understood. Objective: The current study aims to determine some biochemical parameters in old Iraqi COVID-19 patients and highlight the outcomes according to the aging role in the development of COVID-19 by suggesting new mechanisms. Materials and methods: forty COVID-19 patients were enrolled in the current study and divided into two groups: Gm includes (20) men, and Gf includes (20) women. The parameters (Na+, K+, Cl-, LDH, and Hb ) were determined in sera of patients and control groups, G1: healthy men and G2: healthy women. Results: The results reported that the levels of sodium, chloride, and ( hemoglobin for men) were highly significantly decreased. In contrast, potassium level was highly significantly increased in Gm and Gf compared to G1 and G2, respectively, and hemoglobin level in women was decreased in Gf compared with G2. LDH activity did not significantly increase in Gm compared with G1, while it increased dramatically in Gf compared with G2. The difference between Gm and Gf was non-significant for sodium, potassium, chloride, and hemoglobin, but it was highly significant for lactate dehydrogenase. Conclusions: The present study proposed definite mechanisms to elucidate hyponatremia, hyperkalemia, and hypochloremia in old COVID-19 patients by highlighting both COVID-19 complications and risk factors linked to age progression. At the same time, it revealed an interesting biochemical relationship between higher activity of LDH, hyponatremia, and hypochloremia in the same patients .

show abstract

“…The combined effect of high combined BP and anemia played a significant role in increasing the mortality of both CVD and stroke. Based on the fact that the presence of anemia is an independent risk factor for CVD events [ 32 – 34 ], anemic status accompanied by high BP might exacerbate the ischemic condition, resulting in higher CVD morbidity and mortality. Contrary to our expectation, high combined BP was associated with increased total CVD and stroke-specific mortality in the younger age group, as well as the risk of earlier death.…”

Section: Discussionmentioning

confidence: 99%

Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: A community-based cohort study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Objectives This study aimed to examine the risk of cardiovascular disease (CVD) death according to blood pressure levels and systolic and/or diastolic hypertension. Methods From 20,636 cohort participants, 14,375 patients were enrolled after patients with prior hypertension on antihypertensive drugs were excluded. For the combination analysis, participants were divided into four groups (systolic/diastolic hypertension, systolic hypertension only, diastolic hypertension only, and non-hypertension). The risk of CV death was calculated using the hazard ratio (HR) and 95% confidence intervals (95% CI) in a Cox regression model. Results The risk of CVD death increased in systolic hypertension (HR = 1.59, 95% CI 1.26–2.00) and systolic/diastolic hypertension (HR = 1.84, 95% CI 1.51–2.25). The highest risks of hemorrhagic and ischemic stroke were observed in the diastolic hypertension (HR = 4.11, 95% CI 1.40–12.06) and systolic/diastolic hypertension groups (HR = 2.59, 95% CI 1.92–3.50), respectively. The risk of CVD death was drastically increased in those with SBP≥120 mmHg/DBP≥80 mmHg. The highest risk was observed in those with SBP of 130–131 mmHg and 134–137 mmHg. Conclusion The combined analysis of systolic and/or diastolic hypertension appears to be a good predictor of CVD death. The risk of CVD death in the prehypertensive group could be carefully monitored as well as in the hypertensive group, presumably due to less attention and the lack of antihypertensive treatment.

show abstract

Sex-specific Associations Between Serum Hemoglobin Levels and the Risk of Cause-specific Death in Korea Using the National Health Insurance Service-National Health Screening Cohort (NHIS HEALS)

Cited by 6 publications

References 26 publications

Coronary Atherosclerotic Disease and Cancer: Risk Factors and Interrelation

Coronary Atherosclerotic Disease and Cancer: Risk Factors and Interrelation

Biochemical Role of Blood Electrolytes in Old Iraqi Patients with COVID-19

Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: A community-based cohort study

Contact Info

Product

Resources

About