Sex-specific associations of myocardial perfusion imaging with outcomes in patients with suspected chronic coronary syndrome

Georgiopoulos, Georgios; Mavraganis, Georgios; Aimo, Alberto; Giorgetti, Alejandro; Cavaleri, Samuele; Fabiani, Iacopo; Giannoni, Alberto; Emdin, Michele; Gimelli, Alessia

doi:10.1016/j.hjc.2022.12.008

Cited by 1 publication

(1 citation statement)

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“…Besides the established role of fixed and reversible perfusion deficits in the diagnosis of suspected CAD, other findings, such as transient left ventricular dilatation and the presence of large reversible perfusion defects, may offer important prognostic information in terms of clinical events, and most importantly, mortality. Indeed, it has previously been shown that specific thresholds of the extent of SPECT MPI-detected ischemia may have a significant independent prognostic role, and thus, may lead to an improvement in the risk stratification of patients with suspected CAD and potential refinement of treatment in these patients [ 10 , 17 , 18 , 19 ]. The presence of transient left ventricular dilation has been associated with the diagnosis of extensive, severe CAD and poor prognosis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience

Zotou

Bechlioulis

Tsiouris

et al. 2023

JPM

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Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting major cardiovascular events. Methods: The study population was composed of 614 consecutive patients (mean age: 67 years, 55% male) referred for SPECT MPI due to symptoms of stable CAD. The SPECT MPI was performed using a single-day protocol. We conducted a follow-up on all patients at 12 months via a telephone interview. Results: The majority of our patients (78%) presented findings suggestive of reversible ischemia, fixed defects or both. Extensive perfusion defects were found in 18% of the population, while LV dilation was found in 7%. During the 12-month follow-up, 16 deaths, 8 non-fatal MIs and 20 non-fatal strokes were recorded. There was no significant association of SPECT findings with the combined endpoint of all-cause death, non-fatal MI and non-fatal stroke. The presence of extensive perfusion defects was an independent predictor of mortality at 12 months (HR: 2.90, 95% CI: 1.05, 8.06, p = 0.041). Conclusions: In a high-risk patient population with suspected stable CAD, only large reversible perfusion defects in SPECT MPI were independently associated with mortality at 1 year. Further trials are needed to validate our findings and refine the role of SPECT MPI findings in the diagnosis and prognosis of cardiovascular patients.

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