Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China

Ge, Xiaoting; Yang, Aimin; Huang, Sifang; Luo, Xiaoyu; Hou, Qingzhi; Huang, Lulu; Zhou, Yanting; Li, Defu; Lv, Yingnan; Li, Longman; Cheng, Hong; Chen, Xiang; Zan, Gaohui; Tan, Yanli; Liu, Chaoqun; Xiao, Lili; Zou, Yue; Yang, Xiaobo

doi:10.1016/j.scitotenv.2020.143906

Cited by 42 publications

(20 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study of 1470 women [37], hair Co concentrations were found to be lower in women with diabetes. It has also been found [41] that higher Co concentrations are more likely to occur in women, and in the present study there was an interaction between serum Co and gender, with an enhanced negative association with the risk of developing T2DM with Co in the female population relative to men. Co is the metallic component of vitamin B12 [40], and previous studies have suggested that vitamin B12 deficiency may be associated with increased obesity, insulin resistance, and diabetes [38].…”

Section: Discussionsupporting

confidence: 76%

How are cobalt, selenium, and copper related to diabetes risk? A cohort study in rural areas of Xinxiang city

Tian,

Cao,

You

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The long-term associationsbetween serum cobalt (Co), copper (Cu) and selenium (Se) intake and the risk of type 2 diabetes mellitus (T2DM) are unclear. This study aimed to explore the relationship between serum Co, Cu, and Se intake and the risk of T2DM in rural areas of central China. Methods: We used the method developed by our group for the simple, rapid and accurate detection of elements in serum by ICP-MS. Determine T2DM through valid questionnaires and laboratory tests. The Poisson regression model based on robustness under generalized linear regression was used to analyze metals, and the BKMR model was used to analyze the interaction of three mixed metals. Results: A total of 3817 adults were included in the rural cohort study in Henan, and a total of 177 patients with T2DM were diagnosed. In the polymetallic model, stratified analyses revealed an overall negative correlation between serum Co, with intermediate concentrations associated with a non-significant risk of T2DM and high concentrations associated with a 34% (95% CI: 0.44, 1.00) reduction in the risk of T2DM relative to low concentrations. Serum Se was negatively correlated overall, with intermediate concentrations associated with a 41% (95% CI: 0.40, 0.85) lower risk of developing T2DM and high concentrations associated with a non-significant risk of developing T2DM, relative to low concentrations; A significant interaction between serum Se and age (P < 0.049) was found within each stratum, with significant interactions between age and T2DM, and a significant interaction between age and T2DM within each stratum. A significant interaction was found between serum Se and age (P < 0.049), with the negative association of serum Se with T2DM being enhanced in the younger (< 60 years) study population, and a significant interaction was found between serum Co levels and gender (P < 0.012), with the negative association of serum Co with T2DM also being enhanced in the female study population. Conclusion: Cobalt metal exposure was protective in the development of diabetes and was stronger in the female population; selenium metal exposure was protective in the development of diabetes and was stronger in people younger than 60 years.

show abstract

Section: Discussionsupporting

confidence: 76%

How are cobalt, selenium, and copper related to diabetes risk? A cohort study in rural areas of Xinxiang city

Tian,

Cao,

You

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Heavy metals can affect mitochondrial mechanisms and increase the production of free radicals, leading to oxidative stress and inflammation, both of which might play a role in metabolic disorders, such as diabetes mellitus or obesity 6 . However, the effects of metal exposure, especially mixed exposure to multiple metals, on diabetes mellitus development have not been fully studied 7 . Most previous studies on the association between metal exposure and elevated FBG or diabetes mellitus risk have focused on single‐metal exposure models 8 , which might ignore the problem of strong correlation or even collinearity between metals and the impact of metal interactions on health 7 .…”

Section: Introductionmentioning

confidence: 99%

“…However, the effects of metal exposure, especially mixed exposure to multiple metals, on diabetes mellitus development have not been fully studied 7 . Most previous studies on the association between metal exposure and elevated FBG or diabetes mellitus risk have focused on single‐metal exposure models 8 , which might ignore the problem of strong correlation or even collinearity between metals and the impact of metal interactions on health 7 . Although several recent studies have explored the relationship between multi‐metal exposure and diabetes mellitus risk, their conclusions are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…Although several recent studies have explored the relationship between multi‐metal exposure and diabetes mellitus risk, their conclusions are inconsistent. Several population‐based epidemiological surveys from different regions have found that magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), cadmium (Cd), copper (Cu) and lead (Pb) are associated with FBG or diabetes mellitus prevalence 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , whereas other studies have found no association 3 , 16 , 17 , 18 , 19 . Furthermore, the interaction of metals presents a challenge for correlation exploration.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Zhang

Yin

Zhu

et al. 2022

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction: Metals play an important role in diabetes mellitus. This crosssectional study aimed to evaluate the overall, individual and interactive effects of multimetal exposure on the prevalence of diabetes mellitus, impaired fasting glucose (IFG) rate and fasting blood glucose (FBG) levels. Materials and Methods:The FBG levels of a study population from a cadmium (Cd)polluted area (n = 250) and an unpolluted area (n = 204), and the metal levels, including magnesium, calcium (Ca), iron (Fe), zinc (Zn), arsenic (As), Cd, copper and lead (Pb) in blood and urine were detected. The study population was divided into a normal fasting glucose group, an IFG group and a diabetes mellitus group on the basis of FBG levels. Results: The IFG rate and diabetes mellitus prevalence were negatively associated with blood Cd and urine Zn levels (IFG rate: odds ratio [OR] 0.780, 95% confidence interval [CI] 0.655-0.928; OR 0.622, 95% CI 0.465-0.831. Diabetes mellitus prevalence: OR 0.506, 95% CI 0.288-0.888; OR 0.609, 95% CI 0.395-0.939), the IFG rate was positively associated with urine Fe levels (OR 1.876, 95% CI 1.290-2.778), and diabetes mellitus prevalence was positively associated with urine Pb and blood Fe levels (OR 1.185, 95% CI 1.022-1.376; OR 1.008, 95% CI 1.001-1.014). A linear negative correlation was observed between FBG levels and blood Cd, and non-linear inverted U-shaped associations were found between FBG levels and Zn, Pb and copper in urine. Conclusions: This research suggests that multi-metal exposure, especially Cd, Fe, Zn, copper and Pb, is linked to diabetes mellitus, and the interactive effects of multiple metals require further exploration.

show abstract

“…For example, geographic differences regarding soil conditions and agricultural practices are conditioning factors of Se consumption and its status in different populations around the world [ 31 ]. On the other hand, due to the possible role of sex hormones in diabetes and the pathophysiology of metabolic diseases, recent studies have suggested exploring sex-specific associations of trace elements and metal exposure with diabetes risk and FPG level [ 29 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

et al. 2022

View full text Add to dashboard Cite

Selenium (Se) is an essential trace element that by its antioxidant properties has been studied to elucidate its participation in the development of obesity and type 2 diabetes. We evaluated the association between cardiometabolic traits and serum Se levels in a sample of adults from southern Mexico. In 96 nondiabetic individuals, anthropometric data and clinical biochemistry measurements were analyzed. Serum total Se levels were measured with inductively coupled plasma mass spectrometry (ICP-MS). Serum Se level in the whole sample was 10.309 ± 3.031 μg mL−1 and no difference between the women and men was observed (p = 0.09). Additionally, fasting plasma glucose (FPG) was significantly associated with serum Se level (β = −0.07 ± 0.03, p = 0.02, analysis adjusted for age, sex and BMI). Furthermore, sex shows significant interaction with FPG on the serum Se levels (p = 0.01). A follow-up analysis revealed the particular association between FPG and Se levels in women (β = −0.10 ± 0.04, p = 0.01). In conclusion, our data evidenced a women-specific association between FPG and serum Se levels in a sample of adults from southern Mexico.

show abstract

Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China

Cited by 42 publications

References 65 publications

How are cobalt, selenium, and copper related to diabetes risk? A cohort study in rural areas of Xinxiang city

How are cobalt, selenium, and copper related to diabetes risk? A cohort study in rural areas of Xinxiang city

Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

Contact Info

Product

Resources

About