Sex-Specific Differences in Cognitive Abilities Associated with Childhood Cadmium and Manganese Exposures in School-Age Children: a Prospective Cohort Study

Zhou, Tong; Guo, Jianqiu; Zhang, Jiming; Xiao, Hongxi; Qi, Xiaojuan; Wu, Chunhua; Chang, Xiuli; Zhang, Yubin; Liu, Qiang; Zhou, Zhijun

doi:10.1007/s12011-019-01703-9

Cited by 51 publications

(28 citation statements)

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“…Inconsistent conclusions were drawn from three cohort studies, one measured manganese in cord blood and spot urine [ 39 ], the other two sampled dentine of incisors [ 37 , 38 ] (see Table 1 ). The birth cohort study in China reported that urinary Mn concentrations, but not cord blood manganese, were positively associated with Performance IQ of school-age children, especially in girls [ 39 ]. Mora et al (2015) found that higher prenatal and early postnatal manganese in teeth (T-Mn) were adversely associated with behavioral outcomes, namely internalizing, externalizing and hyperactivity problems, in children at 7 and 10.5 years.…”

Section: Resultsmentioning

confidence: 99%

“…Sex interaction p -values in the remaining two reports were not available. Positive association between urinary Mn concentrations and Performance IQ of children was observed, especially in girls [ 39 ]. And Claus Henn et al (2018) found significantly negative associations between T-Mn and visual spatial score, among boys only [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Perhaps there was a trend showing that girls were more susceptible to manganese exposure than boys. While almost all studies found no significant sex differences for Mn in biomarkers and drinking water, except for four studies without the relevant details available [34,39,54,67]. Given that most studies were not specifically designed to evaluate sex-interactions, therefore, low statistical power may in part explain some of the inconsistency between studies.…”

Section: Sex Specific Exposure-response Relationshipsmentioning

confidence: 97%

Section: Manganese In Biomarkers and Neurodevelopmental Outcomesmentioning

confidence: 99%

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Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

Liu

Xin

et al. 2020

Environ Health

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Background Although prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker. Methods We searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators. Results Of 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L). Conclusions Higher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Sex Specific Exposure-response Relationshipsmentioning

confidence: 97%

Section: Manganese In Biomarkers and Neurodevelopmental Outcomesmentioning

confidence: 99%

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Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

Liu

Xin

et al. 2020

Environ Health

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“…Therefore cadmium reaches the fetus and the brain during early development stages of fetus or children [ 53 ]. It has been suggested that cadmium directly affects the development of the central nervous system[ 3 , 66 ] and associated with behavioral and cognitive dysfunction, including poor learning memory in children during early life [ 2 , 52 , 67 – 69 ]. Cadmium levels are measured in the umbilical cord blood, maternal urine, and placenta of women, after the In utero exposure that is correlated with the adverse pregnancy outcomes and infants' health.…”

Section: Neurobehavioural and Cognitive Dysfunctionsmentioning

confidence: 99%

Developmental toxicity of cadmium in infants and children: a review

Chandravanshi¹,

Shiv

Kumar

2021

Environ Anal Health Toxicol

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effects and may not recover quite often. Chronic exposure of low-level cadmium may also occur via breast milk and cereals based complementary food, seafood, and vegetables for infants in mostly low-income families. [25][26][27]. Prenatal and postnatal cadmium exposures have been associated with a variety of adverse pregnancy outcomes including, malformations, decrease fetal growth rate, low birth weight, mortality, further, it may associated with the development of the various disease in children or later life [28][29][30][31]. A negative correlation between the cord blood level of cadmium and fetal growth has been observed in cadmium-exposed population in different areas of the world [30,32,33]. Urinary cadmium levels have been measured with Median cadmium concentrations 0.30, 0.16, and 0.30 g/L in the urine of 1.5, 5 years, and 3-month-old children. On the other hand, it's also observed that the concentration of cadmium in the infant's urine correlated with concentrations in maternal breast milk, saliva, and urine in a rural area of Bangladesh [34].Nutritional deficiencies and poor detoxification by affecting the process of methylation are other important factors that may increase the toxicity of cadmium [35]. Population-based studies on children and mothers have reported a correlation between In utero cadmium exposure and cord blood DNA methylation or birth weight [34,36]). Prenatal chronic exposure to cadmium influence the anthropometric development and growth of the fetus have been linked to later IQ (Intelligence quotient) development in children [34,37].A number of epidemiological studies have revealed that In utero and early life chronic exposure to cadmium may cause neurological problems including cognitive deficits, attention deficit hyperactivity disorder (ADHD), social, and attention in young and children [38][39][40]). Epidemiological studies were also found that children living in an area, contaminated with cadmium even at low exposure levels were associated with enhanced oxidative stress with DNA damage and protein modification in early life and associated with the higher risk of developing cardiovascular disease, osteoporosis and some types of cancer [41][42][43][44]. These are some possible mechanisms to monitor associations between In utero or early life cadmium exposure and susceptibility to chronic diseases.In this review, we organized the study to report, chronic cadmium exposure during In utero and early life and linked with long term health consequences and risk of pregnancy outcomes, neurological, cancer, and renal disease. MethodsA literature review has been conducted, using free literature search database 'PubMed' along with 'Google Search Engine. These sources were searched using keywords such as: cadmium or cadmium* and In utero*, early life*, prenatal*, postnatal*, perinatal*, gestational, lactational, developmental*, pregnancy outcomes, neurobehavioral, behavior*, cognitive dysfunctions IQ* cancer, renal disease, kidney dysfunction etc. All types of appropriate human and animal, stud...

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Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)

Venkatesan,

Muthukumar,

Iyer

et al. 2024

J Biochem & Molecular Tox

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Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.

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Sex-Specific Differences in Cognitive Abilities Associated with Childhood Cadmium and Manganese Exposures in School-Age Children: a Prospective Cohort Study

Cited by 51 publications

References 48 publications

Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

Developmental toxicity of cadmium in infants and children: a review

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)

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