Sex-Specific Differences in Lipid and Glucose Metabolism

Varlamov, Oleg; Bethea, Cynthia L.; Roberts, Charles T.

doi:10.3389/fendo.2014.00241

Cited by 265 publications

(277 citation statements)

References 133 publications

(133 reference statements)

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“…On the other hand, as reported by Fleg and colleagues, men tend to have higher values of VO 2 peak, but a greater decline with aging in the levels of VO 2 peak compared to women (Fleg et al ., 2005). In addition, many gender‐related factors could influence the relationship between ceramides and VO 2 peak, some of which in the current study we were not be able to fully account for, such as sex‐specific differences in lipid metabolism (Varlamov et al ., 2015) and sex‐specific plasticity of the cardiovascular system to fitness and physical activity in older adults (Parker et al ., 2010). Indeed, further and more specific investigations are required to fully disentangle the complex relationship between sex, ceramides, and cardiovascular health.…”

Section: Discussionmentioning

confidence: 99%

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54–96 years from the Baltimore Longitudinal Study of Aging

Fabbri

Simonsick

et al. 2016

Aging Cell

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SummaryCardiorespiratory fitness (VO 2 peak) declines with age and is an independent risk factor for morbidity and mortality in older adults. Identifying biomarkers of low fitness may provide insight for why some individuals experience an accelerated decline of aerobic capacity and may serve as clinically valuable prognostic indicators of cardiovascular health. We investigated the relationship between circulating ceramides and VO 2 peak in 443 men and women (mean age of 69) enrolled in the Baltimore Longitudinal Study of Aging (BLSA). Individual species of ceramide were quantified by HPLC–tandem mass spectrometry. VO 2 peak was measured by a graded treadmill test. We applied multiple regression models to test the associations between ceramide species and VO 2 peak, while adjusting for age, sex, blood pressure, serum LDL, HDL, triglycerides, and other covariates. We found that higher levels of circulating C18:0, C20:0, C24:1 ceramides and C20:0 dihydroceramides were strongly associated with lower aerobic capacity (P < 0.001, P < 0.001, P = 0.018, and P < 0.001, respectively). The associations held true for both sexes (with men having a stronger association than women, P value for sex interaction <0.05) and were unchanged after adjusting for confounders and multiple comparison correction. Interestingly, no significant association was found for C16:0, C22:0, C24:0, C26:0, and C22:1 ceramide species, C24:0 dihydroceramide, or total ceramides. Our analysis reveals that specific long‐chain ceramides strongly associate with low cardiovascular fitness in older adults and may be implicated in the pathogenesis of low fitness with aging. Longitudinal studies are needed to further validate these associations and investigate the relationship between ceramides and health outcomes.

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Section: Discussionmentioning

confidence: 99%

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54–96 years from the Baltimore Longitudinal Study of Aging

Fabbri

Simonsick

et al. 2016

Aging Cell

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“…Sex related differences in lipolysis, glucose metabolism and insulin action are very well described [38]. In summary, women have higher percentage body fat (mostly deposited in the lower body), lower lean mass, more subcutaneous adipose tissue (abdominal and gluteofemoral locations) and higher insulin sensitivity, whereas men have more visceral fat stores in the abdomen or upper body, have higher lean mass and are less sensitive to the action of insulin [38].…”

Section: Insulin Resistancementioning

confidence: 99%

Metabolic Syndrome: Does it Differ Between Women and Men?

Rochlani

Pothineni

Mehta

2015

Cardiovasc Drugs Ther

130

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Cardiovascular disease represents a massive healthcare burden worldwide. Gender differences in the pathophysiology, presentation and prognosis of cardiovascular disease have been described in the literature. Metabolic syndrome, characterized by a cluster of metabolic abnormalities is associated with increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. With the global obesity epidemic, the prevalence of metabolic syndrome is rising rapidly in the developed as well as developing world. However, there is considerable variation in the prevalence based on geography, age, sex and, definition used for diagnosis. Data on gender related differences in metabolic syndrome is relatively scarce. Here, we aim to review the gender differences in epidemiology and pathophysiology of metabolic syndrome as well as its individual components. Knowledge of gender differences in metabolic syndrome can help design gender specific preventative and therapeutic strategies that will have a positive impact on overall population health.

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“…A limitation of our study is that it was performed in male volunteers only and it can be expected that sex differences are present, because it is known that there are several sex-specific differences in energy metabolism (28). A second limitation of our study design is the lack of subjective ratings of hunger, thirst and satiety, and regular consumption habits.…”

Section: Discussionmentioning

confidence: 99%

The effect of consumption temperature on the homeostatic and hedonic responses to glucose ingestion in the hypothalamus and the reward system

Opstal

Berg-Huysmans

Hoeksma

et al. 2018

The American Journal of Clinical Nutrition

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Background: Excessive consumption of sugar-sweetened beverages (SSBs) has been associated with obesity and related diseases. SSBs are often consumed cold, and both the energy content and temperature might influence the consumption behavior for SSBs. Objective: The main aim of this study was to elucidate whether consumption temperature and energy (i.e., glucose) content modulate homeostatic (hypothalamus) and reward [ventral tegmental area (VTA)] responses. Design: Sixteen healthy men participated in our study [aged 18-25 y; body mass index (kg/m 2 ): 20-23]. High-resolution functional magnetic resonance imaging data were collected after ingestion of 4 different study stimuli: plain tap water at room temperature (22°C), plain tap water at 0°C, a glucose-containing beverage (75 g glucose dissolved in 300 mL water) at 22°C, and a similar glucose drink at 0°C. Blood oxygen level-dependent (BOLD) changes from baseline (7 min preingestion) were analyzed over time in the hypothalamus and VTA for individual stimulus effects and for effects between stimuli. Results: In the hypothalamus, water at 22°C led to a significantly increased BOLD response; all other stimuli resulted in a direct, significant decrease in BOLD response compared with baseline. In the VTA, a significantly decreased BOLD response compared with baseline was found after the ingestion of stimuli containing glucose at 0°C and 22°C. These responses were not significantly modulated by consumption temperature. The consumption of plain water did not have a significant VTA BOLD effect. Conclusions: Our data show that glucose at 22°C, glucose at 0°C, and water at 0°C lowered hypothalamic activity, which is associated with increased satiation. On the contrary, the consumption of water at room temperature increased activity. All stimuli led to a similar VTA response, which suggests that all drinks elicited a similar hedonic response. Our results indicate that, in addition to glucose, the low temperature at which SSBs are often consumed also leads to a response from the hypothalamus and might strengthen the response of the VTA. This trial was registered at www.clinicaltrials.gov as NCT03181217.Am J Clin Nutr 2018;107:20-25.

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Sex-Specific Differences in Lipid and Glucose Metabolism

Cited by 265 publications

References 133 publications

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54–96 years from the Baltimore Longitudinal Study of Aging

Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54–96 years from the Baltimore Longitudinal Study of Aging

Metabolic Syndrome: Does it Differ Between Women and Men?

The effect of consumption temperature on the homeostatic and hedonic responses to glucose ingestion in the hypothalamus and the reward system

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