2023
DOI: 10.1161/atvbaha.122.318247
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Sex-Specific Differences in Lipoprotein Production and Clearance

Abstract: Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most effective and assessable strategies to prevent and treat cardiovascular disease. The discovery of novel research targets linked to pathways associated with cardiovascular disease development has enhanced our ability to decrease disease burden; however, residual cardiovascular disease risks remain. Advancements in genetics and personalized medicine are essential to understand some of the factors driving residual risk. Biol… Show more

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Cited by 13 publications
(9 citation statements)
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“…However, ApoB levels and the prevalence of high ApoB did not significantly differ between sexes in this study. There have been inconsistent findings regarding ApoB levels by sex in the literature [ 18 , 32 , 33 ]. Serum lipid levels can be influenced by genetic background, hormonal changes, lifestyle factors, and healthcare behaviors, including access to healthcare facilities and adherence to physicians’ recommendations [ 2 , 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, ApoB levels and the prevalence of high ApoB did not significantly differ between sexes in this study. There have been inconsistent findings regarding ApoB levels by sex in the literature [ 18 , 32 , 33 ]. Serum lipid levels can be influenced by genetic background, hormonal changes, lifestyle factors, and healthcare behaviors, including access to healthcare facilities and adherence to physicians’ recommendations [ 2 , 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…There have been inconsistent findings regarding ApoB levels by sex in the literature [ 18 , 32 , 33 ]. Serum lipid levels can be influenced by genetic background, hormonal changes, lifestyle factors, and healthcare behaviors, including access to healthcare facilities and adherence to physicians’ recommendations [ 2 , 32 , 33 ]. However, limited data exist on the ApoB test in the Korean population to determine which factors are associated with ApoB levels.…”
Section: Discussionmentioning
confidence: 99%
“…Sex hormones have a profound impact on gene expression in tissues including the liver, where they regulate inflammation and lipid metabolism (recently reviewed in ( 94 , 95 )). Finasteride treatment resulted in a shift in circulating sex hormones and hepatic sex hormones toward estrogen excess, as reported in the past ( 18 , 50 , 61 , 72 ).…”
Section: Discussionmentioning
confidence: 99%
“…Static measures of LDL-cholesterol have been successfully used in clinical settings to evaluate patient CVD risk (25), however, the kinetics of B-lps likely play a major role in CVD disease pathology (26,27). and due to the difficulties in performing these assays, they are only quantified in a subset of studies.…”
Section: Introductionmentioning
confidence: 99%