2017
DOI: 10.1111/jth.13712
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Sex‐specific differences in the presenting location of a first venous thromboembolism

Abstract: Background The risk of venous thromboembolism (VTE) differs between men and women. Some risk factors seem to influence the presenting location of VTE. Sex-specific differences in the presenting VTE location have not been studied extensively. Methods We analyzed data from the MEGA case-control study and the Hokusai-VTE study, and used published data from the RIETE registry. Data from patients with a symptomatic first VTE were included (MEGA, n = 4953; Hokusai-VTE, n = 6720; RIETE, n = 40 028). Distributions of … Show more

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Cited by 27 publications
(21 citation statements)
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“…In VTE there are differences in risk factors, absolute incidence, presenting location, optimal management strategies, and prognosis between men and women. [1][2][3][4] In women, hormones such as oral contraceptives and hormone therapy (HT) are important VTE risk factors. 5 Mechanistically, studies indicate that use of these hormones results in a procoagulant shift, with a consequential increased risk of VTE.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In VTE there are differences in risk factors, absolute incidence, presenting location, optimal management strategies, and prognosis between men and women. [1][2][3][4] In women, hormones such as oral contraceptives and hormone therapy (HT) are important VTE risk factors. 5 Mechanistically, studies indicate that use of these hormones results in a procoagulant shift, with a consequential increased risk of VTE.…”
Section: Introductionmentioning
confidence: 99%
“…This holds also true for the coagulation system, especially in light of its pathophysiological side, concerning hypercoagulability and its subsequent disease, venous thromboembolism (VTE). In VTE there are differences in risk factors, absolute incidence, presenting location, optimal management strategies, and prognosis between men and women 1‐4 …”
Section: Introductionmentioning
confidence: 99%
“…This is supported by a five‐fold increase in VTE risk in women with reproductive risk factors (Roach et al , ). Gender also appears to modulate presentation of VTE, with data from three large registries demonstrating more frequent PE presentation in women compared to men (Scheres et al , ), with up to 10% more PE in women than men. This sex difference was more marked in unprovoked VTE and was independent of age.…”
Section: Vte Risk In Womenmentioning
confidence: 99%
“…As risk factors for VTE in men are probably more often intrinsic and thus permanent, the subsequent risk of a recurrent event is higher. Second, the presenting location of a first VTE seems to differ between men and women 3 . In women, PE is more frequently the presenting location, whereas in men DVT without a clinical suspicion of PE is more often observed 3 …”
Section: Introductionmentioning
confidence: 99%