Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala

Guily, Pauline; Lassalle, Olivier; Chavis, Pascale; Manzoni, Olivier J.

doi:10.1016/j.isci.2022.103815

Cited by 10 publications

(3 citation statements)

References 99 publications

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“…Nonetheless, our results are not the first to find an effect on the AMPA/NMDA ratio without a corresponding effect on sEPSC amplitude. In the basolateral amygdala, pubescent male rats have a higher AMPA/NMDA ratio than pubescent females but there is no significant difference in sEPSC amplitude [ 85 ]. In the dorsolateral striatum, high alcohol preference mice exhibit a lower AMPA/NMDA ratio than low alcohol preference mice but there is also no change in sEPSC amplitude [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core

Knouse,

Deutschmann,

Nenov

et al. 2023

Biol Sex Differ

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Background Glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral sex differences in these processes are well-established, the neural mechanisms driving these differences are largely unexplored. In these studies, we examine potential sex differences in synaptic plasticity and excitatory transmission within the nucleus accumbens core. Further understanding of baseline sex differences in reward circuitry will shed light on potential mechanisms driving behavioral differences in motivated behavior and psychiatric disease. Methods Behaviorally naïve adult male and female Long-Evans rats, C57Bl/6J mice, and constitutive PKMζ knockout mice were killed and tissue containing the nucleus accumbens core was collected for ex vivo slice electrophysiology experiments. Electrophysiology recordings examined baseline sex differences in synaptic plasticity and transmission within this region and the potential role of PKMζ in long-term depression. Results Within the nucleus accumbens core, both female mice and rats exhibit higher AMPA/NMDA ratios compared to male animals. Further, female mice have a larger readily releasable pool of glutamate and lower release probability compared to male mice. No significant sex differences were detected in spontaneous excitatory postsynaptic current amplitude or frequency. Finally, the threshold for induction of long-term depression was lower for male animals than females, an effect that appears to be mediated, in part, by PKMζ. Conclusions We conclude that there are baseline sex differences in synaptic plasticity and excitatory transmission in the nucleus accumbens core. Our data suggest there are sex differences at multiple levels in this region that should be considered in the development of pharmacotherapies to treat psychiatric illnesses such as depression and substance use disorder.

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Section: Discussionmentioning

confidence: 99%

Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core

Knouse,

Deutschmann,

Nenov

et al. 2023

Biol Sex Differ

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“…The BLA, known as an essential nucleus for emotional behavior, is profoundly reorganized during adolescence at the morphological level and at the level of neuronal and synaptic properties (Guily et al, 2022).…”

Section: 2mentioning

confidence: 99%

Lifespan changes in cannabinoid 1 receptor mRNA expression in the female C57BL/6J mouse brain

Zhao

Huang

et al. 2022

J of Comparative Neurology

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Many brain functions that underlie behavior, cognition, and emotions vary with age, as does susceptibility to neuropsychological disorders. The expression of specific genes that are involved in these functions, such as the genes encoding for oxytocin, its receptors, and apolipoprotein D, varies with age across different brain regions. The cannabinoid 1 receptor (CB1R) is one of the most widely spread G‐protein coupled receptors in the central nervous system and is increasingly recognized for its important contribution to various brain functions. Although changes in CB1R expression with age have been reported in the male mouse brain, they have not been well investigated in the female brain. Here, we used fluorescence in situ hybridization to target CB1R mRNA in the whole brains of female C57BL/6J mice aged 4, 6, 12, 52 (12 months) and 86 weeks (20 months), and quantified CB1R‐positive cells in 36 brain regions across the whole brain. The results showed that CB1R‐positive cells number changed with age. Specifically, CB1R expression increased with age in some subregions of the cortex, decreased with age in the lateral septal area, and reached its lowest level at 52 weeks in the thalamus, hypothalamus, and hindbrain subregions. Cluster analysis revealed that some brain regions shared similar temporal characteristics in CB1R‐positive cell number across the lifespan. Our results provide evidence that investigation of the neural basis of age‐related characteristics of female brain functions is not only warranted but required.

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“…Secara umum, tikus betina lebih banyak tertangkap dibandingkan dengan tikus jantan. Hal ini disebabkan oleh adanya perbedaan pematangan seksual yang berbeda pada tikus jantan dan betina (Guily et al, 2022). Jumlah individu betina juga ditemukan lebih banyak di Kebun Raya Liwa Lampung Barat (Gumay et al, 2020).…”

Section: Rasio Jenis Kelamin Tikus Tertangkapunclassified

Komunitas Tikus, Serangan dan Upaya Pengendaliannya pada Perkebunan Kelapa Sawit Rakyat di Kuantan Singingi

Seprido¹,

Andriani²

2022

J. Penelitian Kelapa Sawit

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Tikus merupakan salah satu hewan yang dapat menyebabkan kerusakan pada tanaman kelapa sawit sehingga juga mempengaruhi perekonomiannya. Pada tanaman menghasilkan, hama ini dapat menyebabkan kerugian hingga 5% dari total CPO/ha/tahun dan kerusakan sebesar 80% pada tanaman belum menghasilkan. Perubahan komposisi hutan menjadi kelapa sawit akan mempengaruhi populasi dan jenis tikus. Penelitian ini dilakukan pada 7 kecamatan di Kabupaten Kuantan Singingi. Penelitian ini menggunakan metode survey. Lokasi pengamatan ditentukan berdasarkan luas areal perkebunan kelapa sawit rakyat yang terletak dalam satu hamparan dengan minimal 10 ha. Pada masing-masing lokasi penelitian dipasang sebanyak 20 perangkap tikus dengan ukuran perangkap 30 cm x 20 cm x 15 cm dengan menggunakan umpan berupa ikan asin bakar dan kelapa bakar (masing masingnya 10 perangkap) pemasangan perangkap dilakukan selama 7 hari per lokasi penelitian. Sebanyak 575 individu tikus tertangkap dan teramati pada penelitian ini dengan rata-ata penangkapan per lokasi adalah 82,14 individu tikus. Ditemukan sebanyak empat jenis tikus yaitu Rattus tiomanicus (56,34%), Rattus argentiventer (42,43%), Rattus rattus (0,70%) dan Rattus exulans (0,53%). Rasio sex tikus secara umum dilokasi penelitian didominasi oleh jenis kelamin tikus betina dengan nilai 0,97. Sedangkan preferensi umpan yang lebih dominan adalah umpan kelapa bakar yaitu tertangkap sebanyak 319 individu tikus sedangkan umpan ikan asin bakar hanya 256 individu tikus. Persentase kelapa sawit terserang pada perkebunan kelapa sawit rakyat ini adalah sebesar 37,19% sedangkan upaya pengendalian hama tikus yang dilakukan oleh kelompok tani kelapa sawit di Kuantan Singingi adalah dengan cara pemasangan umpan beracun, pemasangan perangkap dan perburuan terhadap tikus.

show abstract

Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala

Cited by 10 publications

References 99 publications

Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core

Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core

Lifespan changes in cannabinoid 1 receptor mRNA expression in the female C57BL/6J mouse brain

Komunitas Tikus, Serangan dan Upaya Pengendaliannya pada Perkebunan Kelapa Sawit Rakyat di Kuantan Singingi

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