Sex-specific effects of isolation stress and consumption of palatable diet during the prepubertal period on metabolic parameters

Krolow, Rachel; Noschang, Cristie; Arcego, Danusa Mar; Huffell, Ana Paula; Marcolin, Marina de Lima; Benitz, André N. D.; Lampert, Carine; Fitarelli, Raquel; Dalmaz, Carla

doi:10.1016/j.metabol.2013.04.009

Cited by 37 publications

(31 citation statements)

References 54 publications

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“…The response to CAF diet was different between males and females in some parameters, such as RWAT weight and cholesterol that increased more in CAF-fed males than in CAF-fed females and triglycerides that increased more in CAF-fed males than in CAF-fed females. These results are in line with the reported sex-associated differences in the regulation of proteins controlling body weight [25], and with the gender differential metabolic responses to the consumption of a palatable diet found after administering distinct forms of early stress to the animals [26],[27].…”

Section: Discussionsupporting

confidence: 88%

Effects Of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour

et al. 2014

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Among adolescents, overweight, obesity and metabolic syndrome are rapidly increasing in recent years as a consequence of unhealthy palatable diets. Animal models of diet-induced obesity have been developed, but little is known about the behavioural patterns produced by the consumption of such diets. The aim of the present study was to determine the behavioural and biochemical effects of a cafeteria diet fed to juvenile male and female rats, as well as to evaluate the possible recovery from these effects by administering standard feeding during the last week of the study. Two groups of male and female rats were fed with either a standard chow diet (ST) or a cafeteria (CAF) diet from weaning and for 8 weeks. A third group of males (CAF withdrawal) was fed with the CAF diet for 7 weeks and the ST in the 8th week. Both males and females developed metabolic syndrome as a consequence of the CAF feeding, showing overweight, higher adiposity and liver weight, increased plasma levels of glucose, insulin and triglycerides, as well as insulin resistance, in comparison with their respective controls. The CAF diet reduced motor activity in all behavioural tests, enhanced exploration, reduced anxiety-like behaviour and increased social interaction; this last effect was more pronounced in females than in males. When compared to animals only fed with a CAF diet, CAF withdrawal increased anxiety in the open field, slightly decreased body weight, and completely recovered the liver weight, insulin sensitivity and the standard levels of glucose, insulin and triglycerides in plasma. In conclusion, a CAF diet fed to young animals for 8 weeks induced obesity and metabolic syndrome, and produced robust behavioural changes in young adult rats, whereas CAF withdrawal in the last week modestly increased anxiety, reversed the metabolic alterations and partially reduced overweight.

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Section: Discussionsupporting

confidence: 88%

Effects Of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour

et al. 2014

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“…Other forms of psychosocial stress, including work-related, social, isolation, and socioeconomic stresses, have also been found to predispose individuals to obesity and related metabolic comorbidities, including type 2 diabetes and cardiovascular disease [21–33]. For instance, isolation stress caused increased consumption of high fat foods and altered adipokine levels [30]. Regardless of adversity, adolescent obesity has been associated with increased cortisol levels and disrupted circadian rhythms of these stress hormones, representing hypothalamic-pituitary-adrenal axis overactivity and reactivity and potentially indicating increased stress underlying the obesity [34].…”

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confidence: 99%

Stress- and PTSD-associated obesity and metabolic dysfunction: A growing problem requiring further research and novel treatments

et al. 2014

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Posttraumatic stress disorder (PTSD) is a growing public health concern. More recently, evidence has indicated that PTSD leads to obesity and associated metabolic dysfunction. Possible mechanisms of this link are through dysfunction of the hypothalamic-pituitary-adrenal axis and related moderation of appetite hormones and neural activity, leading to changes in consumptive behaviors. Although research has been examining associations between PTSD and obesity, diabetes, cardiovascular disease, and metabolic syndrome, future research should delineate potential mechanisms for these associations and develop targeted treatments to reduce these metabolic outcomes.

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“…However, one of the important functions is feeding regulation by NPY. It may act as a mediator between stress and food intake (Forbes, Herzog, & Cox, 2012;Forbes & Cox, 2014;Krolow et al, 2013), and the NPY neurons influence feeding behavior by the hypothalamus (Kim & Bi, 2016;van Swieten et al, 2014). In invertebrate insects, NPY was found only in few of Hymenoptera and Lepidoptera insects (Liu et al, 2013;Whitfield et al, 2002), and its function is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Feeding regulation by neuropeptide Y on Asian corn borer Ostrinia furnacalis

Yue

Zhao

2017

Arch Insect Biochem Physiol

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The Asian Corn Borer Ostrinia furnacalis is a major agricultural pest. In this study, a full-length neuropeptide Y (npy) gene in O. furnacalis was sequenced and cloned from cDNA library, which contains an ORF of 273 bp by encoding 90 amino acid residues. The mature OfurNPY is composed of 29 amino acids with amidation in C-terminal. The spatiotemporal expression analysis showed that npy highest expression level was in the midgut of the fifth instar larvae (the gluttony period). When the expression of npy was knocked down by feeding or injecting dsNPY, larval food consumption, body size, and body weight were significantly inhibited compared to controls. These results indicate that NPY is an important regulator in the control of feeding of O. furnacalis.

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Sex-specific effects of isolation stress and consumption of palatable diet during the prepubertal period on metabolic parameters

Cited by 37 publications

References 54 publications

Effects Of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour

Effects Of A Post-Weaning Cafeteria Diet In Young Rats: Metabolic Syndrome, Reduced Activity And Low Anxiety-Like Behaviour

Stress- and PTSD-associated obesity and metabolic dysfunction: A growing problem requiring further research and novel treatments

Feeding regulation by neuropeptide Y on Asian corn borer Ostrinia furnacalis

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