Sex-specific incidence and temporal trends in solid tumours in young people from Northern England, 1968–2005

Magnanti, Brooke; Dorak, M. Tevfik; Parker, Louise; Craft, Alan; James, P. W.; McNally, Richard J.Q.

doi:10.1186/1471-2407-8-89

Cited by 27 publications

(26 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31 A study in England reported an increased melanoma incidence trend for female 15-to 24-year-olds from 1968 through 2005. 29,32 The increasing melanoma incidence, especially in 15-to 19-year-olds, is consistent with our analyses. For 0-to 9-year-olds, melanoma incidence was fairly stable from 1973 through 2009.…”

Section: Discussionsupporting

confidence: 80%

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Harris²,

et al. 2013

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: The incidence of childhood and adolescent melanoma has been significantly increasing up to 2004. Risk factors (fair skin, light-colored hair/eyes, female gender, presence of nevi, family history, increased number of sunburns, and exposure to UV radiation) are associated with melanoma.WHAT THIS STUDY ADDS: This study describes incidence trends of melanoma diagnosed between the ages of 0 and 19 years and from 1973 through 2009 by gender, stage and age at diagnosis, primary site, and exposure to UV radiation. abstract OBJECTIVE: Childhood and adolescent melanoma is rare but has been increasing. To gain insight into possible reasons underlying this observation, we analyzed trends in melanoma incidence diagnosed between the ages of 0 and 19 years among US whites by gender, stage, age at diagnosis, and primary site. We also investigated incidence trends by UV-B exposure levels.METHODS: By using Surveillance, Epidemiology, and End Results (SEER) program data (1973-2009), we calculated age-adjusted incidence rates (IRs), annual percent changes, and 95% confidence intervals for each category of interest. Incidence trends were also evaluated by using joinpoint and local regression models. SEER registries were categorized with respect to low or high UV-B radiation exposure. RESULTS:From 1973 through 2009, 1230 children of white race were diagnosed with malignant melanoma. Overall, pediatric melanoma increased by an average of 2% per year (95% confidence interval, 1.4%-2.7%). Girls, 15-to 19-year-olds, and individuals with low UV-B exposure had significantly higher IRs than boys, younger children, and those living in SEER registries categorized as high UV-B. Over the study period, boys experienced increased IRs for melanoma on the face and trunk, and females on the lower limbs and hip. The only decreased incidence trend we observed was among 15-to 19-yearolds in the high UV-B exposure group from 1985 through 2009. Local regression curves indicated similar patterns.CONCLUSIONS: These results may help elucidate possible risk factors for adolescent melanoma, but additional individual-level studies will be necessary to determine the reasons for increasing incidence trends.

show abstract

Section: Discussionsupporting

confidence: 80%

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Harris²,

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Several recently published studies have reported that bone tumour incidence remains stable over time in spite of an overall increase in cases of childhood cancer (McNally et al, 2001;Stiller et al, 2006a;Magnanti et al, 2008), with one specifically reporting stable incidence of Ewing sarcoma for the time period 1973-2004(Esiashvili et al, 2008. Our observed decrease in the incidence of Ewing sarcoma remains unexplained.…”

Section: Discussioncontrasting

confidence: 36%

“…The majority of these tumours are osteosarcoma or Ewing sarcoma (Stiller et al, 2006a), in the United Kingdom 54% being osteosarcoma, 39% Ewing sarcoma, 2% chondrosarcoma and 5% other types (Stiller, 2007). Worldwide, trends in incidence rates for childhood bone tumours have remained constant (McNally et al, 2001;Stiller et al, 2006a;Magnanti et al, 2008), although a few studies have reported increases (Ajiki et al, 1994;Gurney et al, 1996). The substantial improvement in survival over the past 40 years (Arndt et al, 2007) has been attributed to chemotherapy (Stiller et al, 2006a).…”

mentioning

confidence: 99%

Incidence and survival of childhood bone cancer in northern England and the West Midlands, 1981–2002

et al. 2009

View full text Add to dashboard Cite

There is a paucity of population-based studies examining incidence and survival trends in childhood bone tumours. We used high quality data from four population-based registries in England. Incidence patterns and trends were described using Poisson regression. Survival trends were analysed using Cox regression. There were 374 cases of childhood (ages 0 -14 years) bone tumours (206 osteosarcomas, 144 Ewing sarcomas, 16 chondrosarcomas, 8 other bone tumours) registered in the period 1981 -2002. Overall incidence (per million person years) rates were 2.63 (95% confidence interval (CI) 2.27 -2.99) for osteosarcoma, 1.90 (1.58 -2.21) for Ewing sarcoma and 0.21 (0.11 -0.31) for chondrosarcoma. Incidence of Ewing sarcoma declined at an average rate of 3.1% (95% CI 0.6 -5.6) per annum (P ¼ 0.04), which may be due to tumour reclassification, but there was no change in osteosarcoma incidence. Survival showed marked improvement over the 20 years (1981 -2000) for Ewing sarcoma (hazard ratio (HR) per annum ¼ 0.95 95% CI 0.91 -0.99; P ¼ 0.02). However, no improvement was seen for osteosarcoma patients (HR per annum ¼ 1.02 95% CI 0.98 -1.05; P ¼ 0.35) over this time period. Reasons for failure to improve survival including potential delays in diagnosis, accrual to trials, adherence to therapy and lack of improvement in treatment strategies all need to be considered.

show abstract

“…Other studies of patients aged 15-24 years, using the same database from the northern region of England, have identified a male-specific increase in the incidence of non-melanotic skin cancer, a male-specific decrease for lymphomas and female-specific increases for osteosarcoma, thyroid cancer and melanoma [25,26]. Survival has improved for most other cancers and for both males and females [27].…”

Section: Discussionmentioning

confidence: 90%

Socioeconomic patterning in the incidence and survival of teenage and young adult men aged between 15 and 24 years diagnosed with non–seminoma testicular cancer in northern england

McNally

Basta

Errington

et al. 2015

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. Disease Registry, which is a population-based specialist regional registry. Negative binomial regression was used to examine the relationship between incidence and both the Townsend deprivation score (and component variables) and small-area population density. Cox regression was used to analyse the relationship between survival and both deprivation and population density. Conclusions:This study has shown that increased risk of non-seminoma testicular cancer in teenage and young adult males may be associated with some aspect of more advantaged living. In contrast, greater deprivation is linked with worse survival prospects. The study was ecological by design and so these area-based results may not necessarily apply to individuals.3 Socio-economic patterning in the incidence and survival of males aged 15-24 years diagnosed with non-seminoma testicular cancer in northern England

show abstract

Sex-specific incidence and temporal trends in solid tumours in young people from Northern England, 1968–2005

Cited by 27 publications

References 41 publications

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Incidence and survival of childhood bone cancer in northern England and the West Midlands, 1981–2002

Socioeconomic patterning in the incidence and survival of teenage and young adult men aged between 15 and 24 years diagnosed with non–seminoma testicular cancer in northern england

Contact Info

Product

Resources

About