Sex-specific patterns of age-related cerebral atrophy in a nonhuman primate Microcebus murinus

Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies

“…However, in contrast to humans, significantly reduced volume and thickness were noted in occipital and cingulate regions, whereas the fronto-parietal areas appeared age-invariant (1–11 years, n = 34; [71]). The age differences in the cingulate, temporal and occipital regions were replicated in subsequent studies using manual delineation of brain areas [77], and automated voxel-based [78], or 3D-MRI atlas-based morphometry [79]. In addition, in line with human findings, marked age-related atrophy of the caudate nucleus was consistently reported [71,77–79].…”

“…The age differences in the cingulate, temporal and occipital regions were replicated in subsequent studies using manual delineation of brain areas [77], and automated voxel-based [78], or 3D-MRI atlas-based morphometry [79]. In addition, in line with human findings, marked age-related atrophy of the caudate nucleus was consistently reported [71,77–79]. However, age-related alterations of the premotor cortex and the superior parietal lobule were also described [77,79].…”

Neurobiological substrates of animal personality and cognition in a nonhuman primate (Microcebus murinus)

“…Data analysis was performed using R (R Core Team, 2019 To account for the different delays between the cognitive/ behavioral experiments and MRI, (compare supporting materials Table S1), correlation analyses were conducted twice: (a) with the morphological raw data (actually measured values) and (b) with morphological data corrected for the variable delay using predictions for age-related changes of the different measurements from sex-specific regression models obtained from a larger MRI data set from our colony (Fritz et al, 2020; for regression estimates see Table S2). The main text reports result from the delay-corrected analyses.…”

“…With regard to cerebral aging, biochemical lesions such as the accumulation of iron (Dhenain et al., 1998), deposits of ß‐amyloid peptide (Bons, Mestre, & Petter, 1992; Mestre‐Frances et al., 2000), and aggregation of Tau protein (Delacourte et al., 1995) have been described to naturally develop in aging mouse lemurs. Furthermore, different patterns of brain atrophy, such as ventricular expansion, region‐specific volumetric decline, and cortical white matter shrinkage, were found (Dhenain, Chenu, Hisley, Aujard, & Volk, 2003; Fritz et al, 2020; Kraska et al., 2011; Picq, Aujard, Volk, & Dhenain, 2012; Sawiak, Picq, & Dhenain, 2014). Regarding dietetics, the effects of long‐term caloric restriction and food supplementation, for example with resveratrol (Dal‐Pan, Pifferi, Marchal, Picq, & Aujard, 2011) and omega‐3 polyunsaturated fatty acids (Languille, Aujard, & Pifferi, 2012; Royo et al., 2018; Vinot et al., 2011) have been investigated in mouse lemurs.…”

“…Furthermore, different patterns of brain atrophy, such as ventricular expansion, region-specific volumetric decline, and cortical white matter shrinkage, were found (Dhenain, Chenu, Hisley, Aujard, & Volk, 2003;Fritz et al, 2020;Kraska et al, 2011;Picq, Aujard, Volk, & Dhenain, 2012;Sawiak, Picq, & Dhenain, 2014). Regarding dietetics, the effects of long-term caloric restriction and food supplementation, for example with resveratrol (Dal-Pan, Pifferi, Marchal, Picq, & Aujard, 2011) and omega-3 polyunsaturated fatty acids (Languille, Aujard, & Pifferi, 2012;Royo et al, 2018;Vinot et al, 2011) have been investigated in mouse lemurs.…”