Sex-specific remodeling of T-cell compartment with aging: Implications for rat susceptibility to central nervous system autoimmune diseases

Stojić-Vukanić, Zorica; Pilipović, Ivan; Arsenović-Ranin, Nevena; Dimitrijević, Mirjana; Leposavić, Gordana

doi:10.1016/j.imlet.2021.08.003

Cited by 1 publication

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“…W badaniach z udziałem pacjentów z chorobami autoimmunologicznymi wykazano zmniejszoną całkowitą liczbę komórek regulatorowych w porównaniu ze zdrowymi populacjami (Fletcher et al, 2009;Viglietta et al, 2004). Ponadto stwierdzono, że aktywność Treg zależy od płci i wieku chorych; sugeruje się też, że u kobiet komórek Treg jest znacznie mniej niż u mężczyzn (Afshan et al, 2012;Stojić-Vukanić et al, 2021). Zarówno w RRMS, jak i w postaciach postępujących oprócz limfocytów T wykazano istotną rolę limfocytów B (Zhou et al, 2006).…”

Section: Androgenyunclassified

The role of sex hormones in multiple sclerosis

Lewandowska¹,

Bielecki²

2023

Aktualn Neurol

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Biological differences associated with sexual dimorphism have an impact on many aspects of health, including disease susceptibility, course and prognosis. Significant differences in the incidence and severity of neurological diseases, especially those of autoimmune origin, were found between women and men. Although the reasons for the observed discrepancies are complex, research indicates the key role of sex hormones, which are known to be responsible for the differences in body structure, genitals and sexual behaviour in women and men. Recent data have drawn attention to their impact on the function of the immune and nervous systems, the brain and the spinal cord in particular. Multiple sclerosis is a chronic disease of the central nervous system that affects more than twice as many women as men. The etiopathogenesis of the disease is complex, with genetic and environmental factors playing an important role. There are three main components in the pathology of multiple sclerosis: inflammation, demyelination and neurodegeneration. Studies conducted so far have shown a significant influence of sex hormones, both male and female, on each of these elements. It has been shown in both clinical and experimental studies that sex hormones have not only a strong immunomodulatory, but also neuroprotective and neuroregenerative effect. Recent research on the role of sex hormones in multiple sclerosis has led to a better understanding of the mechanisms underlying the development of this disorder. They also gave hope for the introduction of sex hormones as diagnostic tools, i.e. biomarkers of progression and response to treatment, but above all, as breakthrough therapies.

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Section: Androgenyunclassified

The role of sex hormones in multiple sclerosis

Lewandowska¹,

Bielecki²

2023

Aktualn Neurol

View full text Add to dashboard Cite

show abstract

Sex-specific remodeling of T-cell compartment with aging: Implications for rat susceptibility to central nervous system autoimmune diseases

Cited by 1 publication

References 290 publications

The role of sex hormones in multiple sclerosis

The role of sex hormones in multiple sclerosis

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