2015
DOI: 10.1093/gerona/glv174
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Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode,Caenorhabditis remanei

Abstract: Rapamycin inhibits the nutrient-sensing TOR pathway and extends life span in a wide range of organisms. Although life-span extension usually differs between the sexes, the reason for this is poorly understood. Because TOR influences growth, rapamycin likely affects life-history traits such as growth and reproduction. Sexes have different life-history strategies, and theory predicts that they will resolve the tradeoffs between growth, reproduction, and life span differently. Specifically, in taxa with female-bi… Show more

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Cited by 33 publications
(43 citation statements)
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“…In the ancestral population, virgin females live longer than virgin males (Lind et al. ) and this corresponds to our findings in populations selected for improved learning performance. However, in the downward‐selected lines, the sexual dimorphism in virgin life span was reversed, as virgin males outlived virgin females.…”
Section: Discussionsupporting
confidence: 91%
“…In the ancestral population, virgin females live longer than virgin males (Lind et al. ) and this corresponds to our findings in populations selected for improved learning performance. However, in the downward‐selected lines, the sexual dimorphism in virgin life span was reversed, as virgin males outlived virgin females.…”
Section: Discussionsupporting
confidence: 91%
“…Our results do not imply that fecundity‐longevity trade‐offs are absent in nematodes, since (i) it is present in the random mortality lines; and (ii) down‐regulation of the nutrient‐sensing TOR pathway, which plays a key role as a regulator of life span across different taxa (Johnson, Rabinovitch & Kaeberlein ), results in increased life span at the cost of reduced growth and female fecundity in C. remanei (Lind et al . ). Large females often produce more eggs and the fact that female adult size was not affected by selection on development time may explain the lack of a fecundity cost.…”
Section: Discussionmentioning
confidence: 97%
“…; Lind et al. ). λ ind is estimated by solving the Euler‐Lotka equation for each individual using the lambda function in the popbio package and is analogous to the intrinsic rate of population growth (Stearns ).…”
Section: Methodsmentioning
confidence: 98%
“…Reproduction was analyzed as total reproduction as well as rate-sensitive individual fitness λ ind , which encompasses the timing and number of offspring (Brommer et al 2002;Lind et al 2016). λ ind is estimated by solving the Euler-Lotka equation for each individual using the lambda function in the popbio package and is analogous to the intrinsic rate of population growth (Stearns 1992).…”
Section: Statistical Analysesmentioning
confidence: 99%