Sex-specific transgenerational effects of diet on offspring life history and physiology

Camilleri-Carter, Tara-Lyn; Piper, Matthew D. W.; Robker, Rebecca L.; Dowling, Damian K.

doi:10.1101/2022.05.23.492998

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Importantly, owing to the average lifespan of these fish far exceeding the period of standardized age and dietary treatment, we can conclude that these results are due to some form of short-term trade-off and, therefore, not a product of senescent decline. Indeed, this effect may persist across multiple generations and produce not just inter- but also trans-generational effects of diet, as suggested in a recent study in Drosophila [ 49 ]. Furthermore, our findings may have direct implications for other scenarios of DR, such as intermittent fasting, which could be seen as a series of short fasting events.…”

Section: Discussionmentioning

confidence: 99%

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

et al. 2023

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Fasting increases lifespan in invertebrates, improves biomarkers of health in vertebrates and is increasingly proposed as a promising route to improve human health. Nevertheless, little is known about how fasted animals use resources upon refeeding, and how such decisions affect putative trade-offs between somatic growth and repair, reproduction and gamete quality. Such fasting-induced trade-offs are based on strong theoretical foundations and have been recently discovered in invertebrates, but the data on vertebrates are lacking. Here, we report that fasted female zebrafish, Danio rerio , increase investment in soma upon refeeding, but it comes at a cost of egg quality. Specifically, an increase in fin regrowth was accompanied by a reduction in 24 h post-fertilization offspring survival. Refed males showed a reduction in sperm velocity and impaired 24 h post-fertilization offspring survival. These findings underscore the necessity of considering the impact on reproduction when assessing evolutionary and biomedical implications of lifespan-extending treatments in females and males and call for careful evaluation of the effects of intermittent fasting on fertilization.

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Section: Discussionmentioning

confidence: 99%

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

et al. 2023

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“…As a result, we could have expected an increase in germline mutations [40,44], which ultimately contributed to the reduced egg quality and egg survival during female refeeding. Indeed, this effect may persist across multiple generations and produce not just inter-but also transgenerational effects of diet, as suggested in a recent study in Drosophila [46].…”

Section: Discussionmentioning

confidence: 99%

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

Ivimey‐Cook

Murray

Coriolis

et al. 2022

Preprint

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Fasting increases lifespan in invertebrates, improves biomarkers of health in vertebrates, and is increasingly proposed as a promising route to improve human health. Nevertheless, little is known about how fasted animals use resources upon refeeding, and how such decisions affect putative trade-offs between somatic growth and repair, reproduction, and gamete quality. Such fasting-induced trade-offs are based on strong theoretical foundations and have been recently discovered in invertebrates, but the data on vertebrates is lacking. Here we report that fasted female zebrafish, Danio rerio, increase investment in soma upon refeeding but it comes at a cost of egg quality.Specifically, an increase in fin re-growth was accompanied by a reduction in 24-hours post-fertilization offspring survival. Refed males showed a reduction in sperm velocity and impaired 24-hour post-fertilisation offspring survival. These findings underscore the necessity of considering the impact on eggs and sperm when assessing evolutionary and biomedical implications of lifespan-extending treatments in females and males and call for careful evaluation of the effects of fasting (both during and post) on fertilisation.

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“…Data accessibility. Data and code are published via Dryad: https://doi.org/10.5061/dryad.zkh1893h1 [45].…”

mentioning

confidence: 99%

Sex-specific transgenerational effects of diet on offspring life history and physiology

Camilleri,

Piper,

Robker

et al. 2024

Proc. R. Soc. B.

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Dietary variation in males and females can shape the expression of offspring life histories and physiology. However, the relative contributions of maternal and paternal dietary variation to phenotypic expression of latter generations is currently unknown. We provided male and female Drosophila melanogaster grandparents with diets differing in sucrose concentration prior to reproduction, and similarly subjected their grandoffspring to the same treatments. We then investigated the phenotypic consequences of this dietary variation among the grandsons and granddaughters. We observed transgenerational effects of dietary sucrose, mediated through the grandmaternal lineage, which mimic the direct effects of sucrose on lifespan, with opposing patterns across sexes; low sucrose increased female, but decreased male, lifespan. Dietary mismatching of grandoffspring–grandparent diets increased lifespan and reproductive success, and moderated triglyceride levels of grandoffspring, providing insights into the physiological underpinnings of the complex transgenerational effects on life histories.

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Sex-specific transgenerational effects of diet on offspring life history and physiology

Cited by 3 publications

References 41 publications

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish

Sex-specific transgenerational effects of diet on offspring life history and physiology

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