Sex-stratified outcomes of primary percutaneous coronary intervention: A tertiary care experience

Artani, Azmina; Baloch, Farhala; Laghari, Abid Hussain; Siddiqui, Faraz; Artani, Moiz; Kazmi, Khawar

doi:10.1177/02184923211014001

Cited by 5 publications

(7 citation statements)

References 22 publications

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“…A 5-year retrospective study examined the sex disparity of post-PCI prognosis in patients with STEMI. 35 The findings demonstrated a higher incidence of in-hospital mortality and post-intervention complications in female participants than the male participants. Another study investigating patients with acute coronary syndrome revealed a higher risk of MACE in women after receiving PCI compared with men.…”

Section: Discussionmentioning

confidence: 84%

“…Clinically, women suffer from a higher risk of several cardiac conditions and greater complications. A 5-year retrospective study examined the sex disparity of post-PCI prognosis in patients with STEMI 35. The findings demonstrated a higher incidence of in-hospital mortality and post-intervention complications in female participants than the male participants.…”

Section: Discussionmentioning

confidence: 99%

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Interactions of ST-elevation myocardial infarction, age, and sex and the risk of major adverse cardiovascular events among Chinese adults: a secondary analysis of a single-centre prospective cohort

et al. 2022

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ObjectivesThis study aimed to evaluate the interactions of ST-elevation myocardial infarction (STEMI), ageing and sex with respect to the incidence of major adverse cardiovascular events (MACE) among Chinese adults.DesignSecondary analysis of a single-centre prospective cohort.SettingPatients who were admitted to cardiology clinics of the Affiliated Hospital of Jiangsu University due to acute myocardial infarction (MI) from June 2017 to November 2019 were eligible for inclusion in the study. This research only examined in-hospital cases.ParticipantsPatients aged <18 years or confirmed dead within 24 hours from admission were excluded. A total of 843 adults were included in the analysis.Primary and secondary outcome measuresMACE was defined as any occurrence of cardiovascular mortality, MI recurrence, cardiogenic shock or heart failure. The relative excess risk due to interaction (RERI), attributable proportion (AP) and the synergy index were computed to quantify the interactions. Men without STEMI and adults without STEMI aged <60 years were the reference groups when examining the risk of MACE.ResultsThe female participants with STEMI showed a statistically higher risk of MACE compared with the male participants without STEMI (relative risk (RR): 2.713, CI: 1.350 to 5.426, p=0.005). A 3.327 times higher risk of MACE was detected in the older adults with STEMI (aged ≥60 years) compared with the adults without STEMI aged <60 years (RR: 3.327, CI: 1.414 to 8.955, p=0.01). Older female patients also had an increased risk of MACE (RR: 3.033, CI: 1.432 to 6.777, p=0.005). A positive additive interaction was detected between STEMI and age (RERI: 1.917, CI: 0.196 to 3.637; AP: 0.576, CI: 0.174 to 0.979). STEMI and sex also indicated an additive interaction (AP: 0.459, CI: 0.018 to 0.899).ConclusionIn this Chinese population with MI, the risk of MACE was increased by about 2.7 times in women with STEMI compared with men without STEMI. MACE incidence increased by about 3.3 times in older patients with STEMI compared with younger patients without STEMI. STEMI and age, and STEMI and sex, may have a positive additive interaction.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Interactions of ST-elevation myocardial infarction, age, and sex and the risk of major adverse cardiovascular events among Chinese adults: a secondary analysis of a single-centre prospective cohort

et al. 2022

View full text Add to dashboard Cite

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“…Similar studies have been described before as well, but the main reasons to find this here were problems like higher comorbidity, differences in correct dosage [16][17] , variations in endothelial functions. It was stated by previous analysis that the use of primary PCI over fibrinolytic therapy is much more advantageous in case of acute myocardial infarction, in some cases the future risk for any myocardial event was not reduced by any of these therapies [18][19] . As per previous studies there was much lower chance of long term mortality in women as compared to men.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Ahmed¹,

Shabir²

2022

PJMHS

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Background: The data from the prior studies have reported inconsistencies in the comorbidity burden, and baseline risk profile. Objective: The data provide insights into the sex difference in percutaneous coronary interventions. Study design: It is a retrospective study with statistical approach, conducted in the Department of Cardiology, Rehman Medical Institute Peshawar. Material and Methods: The study was conducted from December 2021 to May 2022. The 400 patients visited the cardiology department of the hospital were included in the study. The selected patients were enrolled in the coronary angiography. The data was collected from cardiology department of two hospitals and analyzed. The ethical and review committee of the hospital approved the study. The informed consent was taken from the selected patients. The data contains demographic features, baselines characteristics, hospital complications and PCI course. The patients having residual stenosis of less than 50% after balloon angioplasty were included in the groups rated as successful PCI groups. Results: Out of 400 patients taken from two hospitals there were 50% female. The women included in the study were 5 years older than the male patients. Women were on average 67 years old and men were 72 years old. Women in general had more cases of coronary angiography, also women were reported with cases like diabetes mellitus, and some of the cases reported congestive heart failure. The success of the procedure was more successful in case of women with 95% of female patients receiving successful procedure. Conclusions: The overview of sex linked variations in PCI was observed in this study. The hospital mortality was found to be high in case of women, there was also not significant differences found between hospital mortalities for NSTE-2CS in case of cardiogenic problems Keywords: Percutaneous coronary interventions (PCI), coronary angiography, cardiogenic shock, Non-ST elevation acute coronary syndrome (NSTE-ACS) and myocardial infraction.

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“…Currently, PCI (Percutaneous coronary intervention) has become a treatment option for AMI through which the patients’ vessels can be dredged in a short time so that the blood flow can be restored. The extent of infarcted myocardium and prognosis are able to get controlled as well [ 5 , 6 ]. In spite of that, complications such as coronary restenosis, ischemia, and malignant ventricular arrhythmias (MVA) after PCI [ 7 ] cannot be completely avoided.…”

Section: Introductionmentioning

confidence: 99%

Construction and validation of nomogram model for predicting the risk of ventricular arrhythmia after emergency PCI in patients with acute myocardial infarction

Wang,

Chen,

Guo

et al. 2024

Aging

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Objective: To make predictions about the risk of MVA (Malignant Ventricular Arrhythmia) after primary PCI (Percutaneous Coronary Intervention) in patients with AMI (Acute Myocardial Infarction) through constructing and validating the Nomogram model. Methods: 311 AMI patients who suffered from emergency PCI in Hefei Second People’s Hospital from January 2020 to May 2023 were selected as the training set; 253 patients suffering from the same symptom in Hefei First People’s Hospital during the same period were selected as the validation set. Risk factors were further screened by means of multivariate logistic and stepwise regression. The nomogram model was constructed, and then validated by using C-index, ROC curve, decision curve and calibration curve. Results: Multivariate logistic analysis revealed that urea, systolic pressure, hypertension, Killip class II-IV, as well as LVEF (Left Ventricular Ejection Fraction) were all unrelated hazards for MVA after emergency PCI for AMI (P<0.05); a risk prediction nomogram model was constructed. The C-index was calculated to evaluate the predictive ability of the model. Result showed that the index of the training and the validation set was 0.783 (95% CI: 0.726-0.84) and 0.717 (95% CI: 0.65-0.784) respectively, which suggested that the model discriminated well. Meanwhile, other tools including ROC curve, calibration curve and decision curve also proved that this nomogram plays an effective role in forecasting the risk for MVA after PCI in AMI patients. Conclusions: The study successfully built the nomogram model and made predictions for the development of MVA after PCI in AMI patients.

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Sex-stratified outcomes of primary percutaneous coronary intervention: A tertiary care experience

Cited by 5 publications

References 22 publications

Interactions of ST-elevation myocardial infarction, age, and sex and the risk of major adverse cardiovascular events among Chinese adults: a secondary analysis of a single-centre prospective cohort

Interactions of ST-elevation myocardial infarction, age, and sex and the risk of major adverse cardiovascular events among Chinese adults: a secondary analysis of a single-centre prospective cohort

Gender Differences in Percutaneous Coronary Intervention Insights from the Coronary Angiography

Construction and validation of nomogram model for predicting the risk of ventricular arrhythmia after emergency PCI in patients with acute myocardial infarction

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