Sexual activity and functioning after risk-reducing salpingo-oophorectomy: Impact of hormone replacement therapy

Johansen, Nora; Liavaag, Astrid H.; Tanbo, Tom; Dahl, Alv A.; Pripp, Are Hugo; Michelsen, Trond M.

doi:10.1016/j.ygyno.2015.11.016

Cited by 46 publications

(50 citation statements)

References 25 publications

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“…7Y10,15Y24 Their results suggest that sexual difficulties are common and can have a significant negative impact on QoL. Several cross-sectional studies have compared women who have undergone RRSO both to the general population 24 and to women at increased risk of ovarian cancer who opt for screening. 7,8 These studies reported a significantly higher likelihood of sexual issues after RRSO.…”

Section: Sexual Difficultiesmentioning

confidence: 99%

See 1 more Smart Citation

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Tucker

Cohen

2017

Int J Gynecol Cancer

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Section: Sexual Difficultiesmentioning

confidence: 99%

“…7,8 These studies reported a significantly higher likelihood of sexual issues after RRSO. 7,8,24 In 1 study of 119 women following RRSO, the prevalence of female sexual dysfunction was 74%. 10 …”

Section: Sexual Difficultiesmentioning

confidence: 99%

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Tucker

Cohen

2017

Int J Gynecol Cancer

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“…There were no significant differences in scores for pleasure or discomfort over this treatment time period. Since studies have shown little difference in sexual activity between use of raloxifene and control, albeit in postmenopausal women, we assume that the reduction in pleasure and increase in discomfort found in this study reflect the effect of goserelin (36).…”

Section: Discussionmentioning

confidence: 57%

RAZOR: A Phase II Open Randomized Trial of Screening Plus Goserelin and Raloxifene Versus Screening Alone in Premenopausal Women at Increased Risk of Breast Cancer

Howell¹,

Ashcroft

Fallowfield

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Ovarian suppression in premenopausal women is known to reduce breast cancer risk. This study aimed to assess uptake and compliance with ovarian suppression using the luteinizing hormone releasing hormone (LHRH) analogue, goserelin, with add-back raloxifene, as a potential regimen for breast cancer prevention. Methods: Women at ≥30% lifetime risk breast cancer were approached and randomized to mammographic screening alone (C-Control) or screening in addition to monthly subcutaneous injections of 3.6 mg goserelin and continuous 60 mg raloxifene daily orally (T-Treated) for 2 years. The primary endpoint was therapy adherence. Secondary endpoints were toxicity/quality of life, change in bone density, and mammographic density. Results: A total of 75/950 (7.9%) women approached agreed to randomization. In the T-arm, 20 of 38 (52%) of women completed the 2-year period of study compared with the C-arm (27/37, 73.0%). Dropouts were related to toxicity but also the wish to have established risk-reducing procedures and proven chemoprevention. As relatively few women completed the study, data are limited, but those in the T-arm reported significant increases in toxicity and sexual problems, no change in anxiety, and less cancer worry. Lumbar spine bone density declined by 7.0% and visually assessed mammographic density by 4.7% over the 2-year treatment period. Conclusions: Uptake is somewhat lower than comparable studies with tamoxifen for prevention with higher dropout rates. Raloxifene may preserve bone density, but reduction in mammographic density reversed after treatment was completed. Impact: This study indicates that breast cancer risk reduction may be possible using LHRH agonists, but reducing toxicity and preventing bone changes would make this a more attractive option. Cancer Epidemiol Biomarkers Prev; 27(1); 58–66. ©2017 AACR.

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“…Quantitative researchers have focused mainly on two issues: the physical effects of RRBSO and women’s satisfaction with undergoing RRBSO. Researchers have discovered the physical effects of inducing menopause through RRBSO, finding that women’s post-surgical experiences commonly include estrogen deprivation symptoms, such as hot flashes, vaginal discomfort, sexual pain and dysfunction, and poorer physical functioning (Johansen et al, 2016; Moldovan, Keating, & Clancy, 2015; Finch & Narod, 2011). Although women who undergo RRBSO before natural menopause experience these symptoms more acutely, post-menopausal women who undergo RRBSO also experience hormone deprivation symptoms (Wierman et al, 2010).…”

mentioning

confidence: 99%

“…Although women who undergo RRBSO before natural menopause experience these symptoms more acutely, post-menopausal women who undergo RRBSO also experience hormone deprivation symptoms (Wierman et al, 2010). The use of hormone replacement therapy among women who have undergone RRBSO (which is controversial and often avoided in the context of hereditary cancer risk) decreases some but not all of these symptoms (Finch & Narod, 2011; Johansen et al, 2016). …”

mentioning

confidence: 99%

Distinctive psychological and social experiences of women choosing prophylactic oophorectomy for cancer prevention

Meadows

Padamsee

Paskett

2018

Health Care for Women International

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Women known to have significantly elevated ovarian cancer risk due to genetic mutations or family history can reduce this risk by surgically removing both ovaries and fallopian tubes (RRBSO, risk-reducing bilateral salpingo-oophorectomy). We used interpretive phenomenological analysis (IPA) to explore the psychosocial experiences of women who chose RRBSO for cancer prevention. We extended the traditional use of IPA to compare the experiences of women who chose RRBSO for cancer prevention to those of women who underwent similar gynecologic surgery for benign indications. The analysis resulted in three superordinate themes describing women’s psychosocial experiences related to RRBSO: (1) psychological facets of cancer risk (2) social support and (3) shared medical decision making. Findings illustrate that women choosing RRBSO for cancer prevention experience heightened psychosocial challenges before and after surgery compared to women undergoing surgery for benign indication. Furthermore, they may need distinct types of information and support from healthcare providers.

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Sexual activity and functioning after risk-reducing salpingo-oophorectomy: Impact of hormone replacement therapy

Cited by 46 publications

References 25 publications

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

RAZOR: A Phase II Open Randomized Trial of Screening Plus Goserelin and Raloxifene Versus Screening Alone in Premenopausal Women at Increased Risk of Breast Cancer

Distinctive psychological and social experiences of women choosing prophylactic oophorectomy for cancer prevention

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