Sexual behaviors, cannabis, alcohol and monkeypox infection

Vallée, Alexandre

doi:10.3389/fpubh.2022.1054488

Cited by 7 publications

(6 citation statements)

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“…Statistical analyses were stratified by sex due to cannabis consumption differences between females and males. 34,35 Cox proportional hazards regression models were used to estimate the hazard ratios (HRs) and 95% CIs for the associations between cannabis use and risk of all-cause mortality and causespecific hazard models for the risk of cause-specific mortality (CV and cancer). Kaplan-Meier analyses censored at 10 years' follow-up were performed and compared by log-rank test.…”

Section: Discussionmentioning

confidence: 99%

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Heavy Lifetime Cannabis Use and Mortality by Sex

Vallée

2024

JAMA Netw Open

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ImportanceThe association between mortality and cannabis use remains unclear.ObjectiveTo examine sex-stratified associations of cumulative lifetime cannabis use with all-cause, cardiovascular disease (CVD), and cancer mortality in the UK Biobank population.Design, Setting, and ParticipantsThis cohort study used data from volunteers in the UK Biobank population. Participant monitoring for mortality in the UK Biobank study commenced from the point of their inclusion between 2006 and 2010 and continued until December 19, 2020. Data regarding the causes of death were sourced from the National Health Service Information Centre. Data were analyzed from inception of study inclusion to December 2020.ExposureCannabis use status was assessed by questionnaire and categorized as heavy, moderate, low, and never.Main Outcomes and MeasuresThe main outcomes were all-cause, CVD, and cancer mortality. Sex-stratified associations of cumulative lifetime cannabis use with mortality were estimated using Cox proportional hazards regression with adjustment for demographic and clinical variables.ResultsAmong 121 895 participants (54.51% females with mean [SD] age of 55.15 [7.64] years; 45.49% males with mean [SD] age of 56.46 [7.79] years) during an overall median of 11.80 years (IQR, 10.53-13.22 years) of follow-up, 2375 total deaths occurred, including 1411 deaths from CVD and 440 from cancer. In males, after full adjustment, the hazard ratios (HRs) were 1.28 (95% CI, 0.90-1.81) for all-cause mortality, 0.98 (95% CI, 0.43-2.25) for CVD mortality, and 1.09 (95% CI, 0.71-1.67) for cancer mortality among heavy cannabis users compared with never users. In females, after full adjustment, the HRs were 1.49 (95% CI, 0.92-2.40) for all-cause mortality, 2.67 (95% CI, 1.19-4.32) for CVD mortality, and 1.61 (95% CI, 0.91-2.83) for cancer mortality among heavy cannabis users compared with never users. In female current tobacco users, after full adjustment, heavy cannabis use was associated with all-cause mortality (HR, 2.25; 95% CI, 1.12-4.53), CVD mortality (HR, 2.56; 95% CI, 1.43-15.36), and cancer mortality (HR, 3.52; 95% CI, 1.50-8.33) and among never tobacco users was associated with CVD mortality (HR, 2.98; 95% CI, 1.67-6.61). In male current tobacco users, heavy cannabis use was associated with cancer mortality (HR, 2.44; 95% CI, 1.14-5.23).Conclusions and RelevanceIn this study, a positive association between CVD mortality and heavy lifetime cannabis use was observed among females. Longitudinal studies are needed in general populations to investigate the potential effects of cannabis on mortality.

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Section: Discussionmentioning

confidence: 99%

“…Pearson χ 2 test was performed for categorical variables. Statistical analyses were stratified by sex due to cannabis consumption differences between females and males …”

Section: Methodsmentioning

confidence: 99%

Heavy Lifetime Cannabis Use and Mortality by Sex

Vallée

2024

JAMA Netw Open

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“…Mpox is not classified as a sexually transmitted infection (STI), although it can spread through intimate contact during sexual activity if there is an active skin rash (Sousa et al., 2022). However, there has been a disproportionate number of cases among gay men and other men who have sex with men (MSM), leading the WHO and some national governments to issue specific recommendations for this group (Macedo & Maciel, 2023; Sousa et al., 2022; Vallée, 2023; World Health Organization, 2023). Notably, official guidelines highlight sexual behavior, advocating for a reduction in practices that involve multiple partners, such as group sex and chemsex (Şahin et al., 2023; Sousa et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

“…In a review (Vallée, 2023), being a young man, MSM, HIV positive, using PrEP, and engaging in hazardous sexual behaviors are factors that increase the risk of MPXV infection. Additionally, participation in chemsex has been associated with higher exposure to STIs (Sexually Transmitted Infections), unprotected sexual practices, and decreased adherence to ART (Antiretroviral Therapy) in individuals with HIV (Giorgetti et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Chemsex among men who have sex with men during the Mpox health crisis in Brazil: A nationwide web survey

Santos,

Ribeiro,

Lima

et al. 2024

Public Health Nursing

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ObjectiveTo understand the factors associated with the practice of chemsex among MSM in Brazil, especially during the Mpox health crisis, and to design effective prevention and intervention strategies specifically for this population.DesignA cross‐sectional and analytical study using an electronic survey, conducted from September to December 2022, during the peak of the Mpox outbreak in Brazil.SampleA total of 1452 MSM aged 18 and older.MeasurementsData were collected via the REDCap platform through a survey with 46 questions. These addressed demographic data, sexual affiliations, practices, experiences with Mpox, healthcare service usage, and stigma or fear related to Mpox.ResultsThe prevalence of chemsex was 19.42% (n = 282). Multivariate Poisson modeling indicated a high incidence of chemsex among those diagnosed with Mpox and those involved in high‐risk behaviors. The practice of chemsex was six times higher among those diagnosed with Mpox (95% CI: 4.73–9.10). MSM who engage in bugchasing had a prevalence twice that of the main outcome (95% CI: 1.31–3.16).ConclusionThere is a significant need for targeted interventions for MSM in Brazil, especially given the Mpox outbreak. This study highlights the strong relationships between chemsex, experiences with Mpox, and various sexual behaviors, underscoring the importance of effective public health initiatives.

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“…[ 2 ] However, there has been no concrete research on Marijuana potential to treat monkeypox. As Vallee[ 3 ] points out, cannabis and alcohol consumption may have two negative effects on the monkeypox virus (MPXV) outbreak: increasing the number of sexual partners, which is primarily responsible for the increase in the number of new MPXV-infected cases, and impairing the immune response to a viral infection. It should be noted, however, that medical Marijuana with a well-controlled therapeutic approach can be useful and is not linked to addiction.…”

mentioning

confidence: 99%