Sexual differences in the magnocellular vasopressinergic system in golden hamsters

Delville, Yvon; Koh, Edward T.; Ferris, Craig F.

doi:10.1016/0361-9230(94)90080-9

Cited by 35 publications

(14 citation statements)

References 29 publications

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“…Sex differences are apparent in adult mice too (Rood et al, 2013). Vasopressin development has been studied in golden hamsters (Delville et al, 1994b), and while male hamsters produce more vasopressin than female hamsters, the sex differences in hamsters are evident in the hypothalamus, and not the extrahypothalamic areas (Delville et al, 1994a). A transient vasopressin immunoreactivity in the cortex in the first postnatal week of golden hamsters has also been reported (Delville et al, 1994b).…”

Section: Dynamic Developmental Profiles: When and Where Are The Factomentioning

confidence: 97%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Section: Dynamic Developmental Profiles: When and Where Are The Factomentioning

confidence: 97%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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“…Marked sex differences have been reported in the magnocellular vasopressinergic neurons of the hamster SON (Delville et al, 1994). Neurons from the human SON in young males are functionally more active than in young females (Ishunina et al,1999).…”

Section: Sex Differencesmentioning

confidence: 98%

Sex differences in the distribution of androgen receptors in the human hypothalamus

et al. 2000

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The present study reports for the first time the distribution of androgen receptor immunoreactivity (AR-ir) in the human hypothalamus of ten human subjects (five men and five women) ranging in age between 20 years and 39 years using the antibody PG21. Prolonged postmortem delay (72:00 hours) or fixation time (100 days) did not influence the AR-ir. In men, intense nuclear AR-ir was found in neurons of the horizontal limb of the diagonal band of Broca, in neurons of the lateromamillary nucleus (LMN), and in the medial mamillary nucleus (MMN). An intermediate nuclear staining was found in the diagonal band of Broca, sexually dimorphic nucleus of the preoptic area, paraventricular nucleus, suprachiasmatic nucleus, ventromedial nucleus, and infundibular nucleus, whereas weaker labeling was found in the bed nucleus of the stria terminalis, medial preoptic area, dorsal and ventral zones of the periventricular nucleus, supraoptic nucleus, and nucleus basalis of Meynert. In most brain areas, women revealed less staining than men. In the LMN and the MMN, a strong sex difference was found. Cytoplasmic labeling was observed in neurons of both sexes, although women showed a higher variability in the intensity of such staining. However, no sex differences in AR-ir were observed in the bed nucleus of the stria terminalis, the nucleus basalis of Meynert, or the islands of Calleja. Species differences and similarities of the AR-ir distribution are discussed. The present results suggest the participation of androgens in the regulation of various hypothalamic processes that are sexually dimorphic.

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“…Similarly, naked mole-rats and hyenas have substantially fewer AVP positive neurons in the extended amygdala and do not display a sex difference in AVP content within these areas(Rosen and others, 2006; Rosen and others, 2007). Interestingly, however, sex differences in AVP concentrations in magnocellular neurons in the SON have been reported in Syrian hamsters, rats and humans(Delville and others, 1994; Madeira and others, 1993; Taylor and others, 2012; Ishunina and Swaab). The limited data available in primates have not identified sex differences in AVP distribution in the extended amygdala(Fliers and others, 1986; Ishunina and others, 1999).…”

Section: Sex Differences In Avt/avp and Their Receptorsmentioning

confidence: 99%

Species, sex and individual differences in the vasotocin/vasopressin system: Relationship to neurochemical signaling in the social behavior neural network

Albers

2015

Frontiers in Neuroendocrinology

169

152

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Arginine-vasotocin(AVT)/arginine vasopressin (AVP) are members of the AVP/oxytocin (OT) superfamily of peptides that are involved in the regulation of social behavior, social cognition and emotion. Comparative studies have revealed that AVT/AVP and their receptors are found throughout the “Social Behavior Neural Network” and display the properties expected from a signaling system that controls social behavior (i.e., species, sex and individual differences and modulation by gonadal hormones and social factors). Neurochemical signaling within the SBNN likely involves a complex combination of synaptic mechanisms that co-release multiple chemical signals (e.g., classical neurotransmitters and AVT/AVP as well as other peptides) and non-synaptic mechanisms (i.e., volume transmission). Crosstalk between AVP/OT peptides and receptors within the SBNN is likely. A better understanding of the functional properties of neurochemical signaling in the SBNN will allow for a more refined examination of the relationships between this peptide system and species, sex and individual differences in sociality.

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Sexual differences in the magnocellular vasopressinergic system in golden hamsters

Cited by 35 publications

References 29 publications

Developmental Perspectives on Oxytocin and Vasopressin

Developmental Perspectives on Oxytocin and Vasopressin

Sex differences in the distribution of androgen receptors in the human hypothalamus

Species, sex and individual differences in the vasotocin/vasopressin system: Relationship to neurochemical signaling in the social behavior neural network

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