Sexual differentiation of gonadotrophin secretion, sexual orientation and gender role behavior

Dörner, G; Döcke, F; Götz, Franziska; Rohde, Wolfgang; Stahl, F; Tönjes, Renate

doi:10.1016/0022-4731(87)90193-2

Cited by 34 publications

(7 citation statements)

References 20 publications

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“…The organizational effects of androgens are thought to be mediated by intracellular conversion of these hormones in certain brain areas to estrogens (Dorner et al 1987), and estrogenic chemicals in the environment have potential adverse effects on animals and humans exposed during embryonic developmental stage (Damstra 2002). To this respect, clinical studies suggest that early hormonal imprinting may influence androgenization not only in rodents but also in women (Rubin et al 1981, Collaer & Hines 1995.…”

Section: Introductionmentioning

confidence: 99%

Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice

Ramírez

Luque²,

Ornstein³

et al. 2010

Journal of Endocrinology

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Abnormal exposure to steroid hormones within a critical developmental period elicits permanent alterations in female reproductive physiology in rodents, but the impact on the female GH axis and the underlying sexual differences in hepatic enzymes have not been described in detail. We have investigated the effect of neonatal androgenization of female mice (achieved by s.c. injection of 100 mg testosterone propionate (TP) on the day of birth: TP females) on the GHRH-somatostatin-GH axis and downstream GH targets, which included female and male predominant liver enzymes and secreted proteins. At 4 months of age, an organizational effect of neonatal testosterone was evidenced on hypothalamic Ghrh mRNA level but not on somatostatin (stt) mRNA level. Ghrh mRNA levels were higher in males than in females, but not in TP females. Increased expression in TP females correlated with increased pituitary GH content and somatotrope population, increased serum and liver IGF-I concentration, and ultimately higher body weight. Murine urinary proteins (MUPs) that were excreted at higher levels in male urine, and whose expression requires pulsatile occupancy of liver GH receptors, were not modified in TP females and neither was liver Mup 1/2/6/8 mRNA expression. Furthermore, a male predominant liver gene (Cyp2d9) was not masculinized in TP females either, whereas two female predominant genes (Cyp2b9 and Cyp2a4) were defeminized. These data support the hypothesis that neonatal steroid exposure contributes to the remodeling of the GH axis and defeminization of hepatic steroid-metabolizing enzymes, which may compromise liver physiology.

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Section: Introductionmentioning

confidence: 99%

Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice

Ramírez

Luque²,

Ornstein³

et al. 2010

Journal of Endocrinology

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“…See: Meyer-Balhburg, 1995, p. 143. 14 Meyer-Bahlburg, 1995 15 Meyer-Bahlburg reports that Dorner, 1988 andDocke, 1987 reported an LH response to estrogen in transsexual and gay men. See: Meyer-Bahlburg, 1995, p. 143.…”

Section: Resultsmentioning

confidence: 99%

The Trouble with Inversion: An examination of science and sexual orientation

Johnston

2018

ateliers

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Although some are excited about the possibility of using current scientific research into the biological causes of sexual orientation to ground rights claims, I argue that basing rights claims on this research is unwise because this research, specifically the hormonal, genetic, and structural research, is organized around the inversion assumption, a conceptual scheme within which some aspect of the biology of gay men and lesbians is thought to be inverted along sex lines. While there are many reasons to worry about the use of the inversion assumption, I focus on problems that arise from a further set of claims that must be assumed in order to make the use of the inversion assumption coherent. This further set of assumptions includes the claims (1) that heterosexuality is the standard state and that (2) this standard state is sexually-dimorphic and (3) deterministic. I argue that this set of assumptions is problematic because it results in ideological consequences that are both sexist and heterosexist.

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“…In light of all of which precedes, it seems to me that one research program which should retain our attention in view of building an integrative theory of CL, is the following experimental animal research agenda: we need to determine the effects of targeted steroid manipulations on relevant neurotransmitter activity (see DiPaolo et al, 1981;Heritage et al, 1981, for examples) and vice versa (see Dorner et al, 1987;Dorner, 1988, for examples) as a function of precise intra-and interhemispheric loci in a developmental (especially prenatal) context. The timing, as well as intensities and durations of these manipulations will have to be very carefully controlled because acute and chronic, and low and high dose developmental manipulations often have opposite effects (see Biegon and McEwen, 1982;Haefner et al 1991).…”

Section: Resultsmentioning

confidence: 99%

The Geschwind–Behan–Galaburda Model (GBGM) of Cerebral Lateralization: A Critique and Prospective

Braun

1996

Behavioural Neurology

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In the wake of, and as a complement to, a recently published major meta-analytic review of empirical support of the Geschwind–Behan–Galaburda model (GBGM) of cerebral lateralization (CL) the present brief essay attempts to present a critical assessment of the theoretical approach underlying the GBGM. The GBGM is criticized for having been misguided in its representation of the cerebral basis of handedness, and of the links between testosterone and immune function. Some guidelines are presented for the development of a general theory of CL, emphasizing animal research, greater interdisciplinary communication, a hierarchical model-building approach, and the relevance of neuropharmacology and psychiatry.

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Sexual differentiation of gonadotrophin secretion, sexual orientation and gender role behavior

Cited by 34 publications

References 20 publications

Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice

Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice

The Trouble with Inversion: An examination of science and sexual orientation

The Geschwind–Behan–Galaburda Model (GBGM) of Cerebral Lateralization: A Critique and Prospective

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