2008
DOI: 10.1016/j.jsbmb.2008.03.003
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Sexual differentiation of the rodent hypothalamus: Hormonal and environmental influences

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Cited by 50 publications
(35 citation statements)
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“…Expression is greater overall for both isozymes in the brainstem than in the forebrain, however, 5 ␣ R2 is found in hypothalamic and hippocampal neurons in adult rodents [Poletti and Martini, 1999]. 5 ␣ R1 has a lower affinity for T and is present in both neurons and glial cells, whereas 5 ␣ R2 has a higher affinity for T and is found primarily in neurons [Negri-Cesi et al, 2008]. Thus, these 2 isozymes may serve somewhat different functions.…”
Section: Introductionmentioning
confidence: 99%
“…Expression is greater overall for both isozymes in the brainstem than in the forebrain, however, 5 ␣ R2 is found in hypothalamic and hippocampal neurons in adult rodents [Poletti and Martini, 1999]. 5 ␣ R1 has a lower affinity for T and is present in both neurons and glial cells, whereas 5 ␣ R2 has a higher affinity for T and is found primarily in neurons [Negri-Cesi et al, 2008]. Thus, these 2 isozymes may serve somewhat different functions.…”
Section: Introductionmentioning
confidence: 99%
“…Given the emergence of environmental substances with androgenic actions in fetal androgenization (10,25), the question arises as to whether developmental androgen excess can program the cardiometabolic features of PCOS. Since developmental testosterone exposure masculinizes the structure and function of the hypothalamus in females (4,33,36,37,47,50), the question also arises as to whether developmental androgen excess programs masculinization of metabolism. Using a mouse model, we reported previously that neonatal androgenization of female mice masculinized the organization of proopiomelanocortin neurons and induced cellular leptin resistance to upregulate the anorexigenic neuropeptide proopiomelanocortin, thereby resulting in failure of leptin to suppress food intake (41).…”
mentioning
confidence: 99%
“…Therefore, to achieve a male-specific brain, it is necessary to activate two independent processes-development of neural circuits enabling expression of male-specific behavior, when activated by testicular hormones (masculinization), and the loss of those able to respond to ovarian hormones (defeminization) during adulthood [33]. The AGD is defined as the distance between the genital papilla and the anus; male rodents have AGDs approximately twice those of females [34] and AGD correlates closely with prenatal exposure to androgens [22].…”
Section: Discussionmentioning
confidence: 99%