Sexual dimorphism in gut microbiota dictates therapeutic efficacy of intravenous immunoglobulin on radiotherapy complications

Wang, Zongkui; Xiao, He; Dong, Jing; Li, Yuan; Wang, Bin; Chen, Zhiyuan; Zeng, Xiaozhou; Liu, Jia; Dong, Yanxi; Ma, Li; Xu, Jun; Liu, Cheng; Li, Changqing; Liu, Xingzhong; Cui, Ming

doi:10.1016/j.jare.2022.06.002

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…Accumulating evidence demonstrates that radiation exposure disrupts normal gut microbiota composition and structure, and that “deteriorative” gut microbiota is involved in the initiation and progression of radiation injury ( Gerassy-Vainberg et al., 2018 ; Wang et al., 2023 ). As expected, the FFT treatment significantly affected both the bacterial and viral composition in the gut of recipient mice, characterized by a clear separation of the vehicle group compared to the FFT group, which is in accordance with the findings of a previous study ( Rasmussen et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

Zhang,

Dong,

Zheng

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundIonizing radiation can cause intestinal microecological dysbiosis, resulting in changes in the composition and function of gut microbiota. Altered gut microbiota is closely related to the development and progression of radiation-induced intestinal damage. Although microbiota-oriented therapeutic options such as fecal microbiota transplantation (FMT) have shown some efficacy in treating radiation toxicity, safety concerns endure. Therefore, fecal bacteria-free filtrate transplantation (FFT), which has the potential to become a possible alternative therapy, is well worth investigating. Herein, we performed FFT in a mouse model of radiation exposure and monitored its effects on radiation damage phenotypes, gut microbiota, and metabolomic profiles to assess the effectiveness of FFT as an alternative therapy to FMT safety concerns.ResultsFFT treatment conferred radioprotection against radiation-induced toxicity, representing as better intestinal integrity, robust proinflammatory and anti-inflammatory cytokines homeostasis, and accompanied by significant shifts in gut microbiome. The bacterial compartment of recipients following FFT was characterized by an enrichment of radioprotective microorganisms (members of family Lachnospiraceae). Furthermore, metabolome data revealed increased levels of microbially generated short-chain fatty acids (SCFAs) in the feces of FFT mice.ConclusionsFFT improves radiation-induced intestinal microecological dysbiosis by reshaping intestinal mucosal barrier function, gut microbiota configurations, and host metabolic profiles, highlighting FFT regimen as a promising safe alternative therapy for FMT is effective in the treatment of radiation intestinal injury.

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Section: Discussionmentioning

confidence: 99%

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

Zhang,

Dong,

Zheng

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Thirdly, the microbiome can influence drug metabolism and effects. Studies have shown that the efficacy of some drugs, such as antibiotics ( 259 ), immunosuppressive drugs ( 260 , 261 ), and anticoagulants ( 262 ), in the treatment of MI may be affected by the microbiome. Therefore, by adjusting the microbiome, drug efficacy can be optimized and therapeutic effects improved.…”

Section: Single-omics Approachesmentioning

confidence: 99%

From multi-omics approaches to personalized medicine in myocardial infarction

Zhan,

Tang,

et al. 2023

Front. Cardiovasc. Med.

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Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

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“… Wang et al . (2023c) showed that combing IVIg with Trichospirillaceae can significantly alleviate radiation-induced hematopoietic system injury and RE in male mice.…”

Section: Gut Microbiota-based Treatment For Radiation Injurymentioning

confidence: 99%

Radiation injury and gut microbiota-based treatment

et al. 2023

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The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and•organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes ten common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.

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Sexual dimorphism in gut microbiota dictates therapeutic efficacy of intravenous immunoglobulin on radiotherapy complications

Cited by 12 publications

References 47 publications

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice

From multi-omics approaches to personalized medicine in myocardial infarction

Radiation injury and gut microbiota-based treatment

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