Sexual Dimorphism in Mitochondrial Dysfunction and Diabetes Mellitus: Evidence from Population-Based Cohort Study

Wang, Shanjie; Guo, Junchen; Liu, Xiaoxuan; Tian, Wenxi; Zhang, Yiyin; Wang, Ye; Liu, Yige; E, Mingyan; Fang, Shanghong

doi:10.2139/ssrn.4069032

Cited by 1 publication

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study ultimately found that young-onset T2D increased the risk of death, primarily through early cardiovascular dis-ease death. Therefore, efforts to delay the onset of T2D may help reduce mortality rates [39].…”

Section: Discussionmentioning

confidence: 99%

Unveiling the Hidden Burden: Estimating All‐Cause Mortality Risk in Older Individuals with Type 2 Diabetes

Pan,

Wang,

et al. 2024

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. The mortality rate among older persons with diabetes has been steadily increasing, resulting in significant health and economic burdens on both society and individuals. The objective of this study is to develop and validate a predictive nomogram for estimating the 5-year all-cause mortality risk in older persons with T2D (T2D). Methods. We obtained data from the National Health and Nutrition Survey (NHANES). A random 7 : 3 split was made between the training and validation sets. By linking the national mortality index up until December 31, 2019, we ensured a minimum of 5 years of follow-up to assess all-cause mortality. A nomogram was developed in the training cohort using a logistic regression model as well as a least absolute shrinkage and selection operator (LASSO) regression model for predicting the 5-year risk of all-cause mortality. Finally, the prediction performance of the nomogram is evaluated using several validation methods. Results. We constructed a comprehensive prediction model based on the results of multivariate analysis and LASSO binomial regression. These models were then validated using data from the validation cohort. The final model includes four independent predictors: age, gender, estimated glomerular filtration rate, and white blood cell count. The C-index values for the training and validation cohorts were 0.748 and 0.762, respectively. The calibration curve demonstrates satisfactory consistency between the two cohorts. Conclusions. The newly developed nomogram proves to be a valuable tool in accurately predicting the 5-year all-cause mortality risk among older persons with diabetes, providing crucial information for tailored interventions.

show abstract

Section: Discussionmentioning

confidence: 99%