Sexual dimorphism in relationships between of plasma urea and some psycho-neuro-endocrine parameters

Anchev²,

et al. 2022

Background. Earlier we found that plasma uric acid and urea causes modulating effects on neuro-endocrine parameters, as well as reactive anxiety, but these effects are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma creatinine level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of creatinine and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma creatinine downregulates the level of Cortisol (r=-0,41) while upregulates the levels of Testosterone (r=0,36) and Calcitonin (r=0,30). The degree of determination of endocrine parameters is 31,9%. In postmenopausal women, creatinine also upregulates Testosterone (r=0,43) while downregulates the amplitude and PSD of β-rhythm in different loci as well as causes right lateralization of β-rhythm. The degree of determination of neuro-endocrine parameters is 61,2%. In women of reproductive age creatinine upregulates the PSD of ULF band HRV and α-rhythm in 5 loci as well as the Entropy of EEG in F3 locus while downregulates the Entropy in T6 locus, F3-δ and T6-θ PSD as well as Cortisol level. The degree of determination of neuro-endocrine parameters is 94,0%. Conclusion. Plasma creatinine has a modulating effect on neuro-endocrine parameters, but this effect is significantly different in men and women of different ages.

Section: Scatterplot Of Canonical Correlation Between Creatinine Plas...mentioning

confidence: 95%

“…Earlier we found that plasma uric acid and urea causes modulating effects on neuro-endocrine parameters, as well as reactive anxiety, but these effects are significantly different in men and women of different ages [4][5][6][7]14].…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism in relationships between of plasma creatinine and some neuro-endocrine parameters

Anchev²,

et al. 2022

“…Earlier we found that effects of plasma nitrogenous metabolites as urea, creatinine, and bilirubin on neuroendocrine parameters, as well as anxiety, are significantly different in men and women of different ages [7][8][9][10][11][12]. The purpose of this study is to analyze the relationships between the plasma uric acid level and some psychoneuro-endocrine parameters in the same cohort.…”

Section: Introductionmentioning

confidence: 96%

Sexual dimorphism in relationships between of plasma uric acid and some psycho-neuro-endocrine parameters

Корда

et al. 2022

Background. Earlier we found that effects of plasma nitrogenous metabolites as urea, creatinine, and bilirubin on neuro-endocrine parameters, as well as anxiety, are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma uric acid level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of uric acid and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By uric acid regression models with stepwise exclusion, it was found that in men plasma uric acid downregulates the PSD of β-rhythm in P4 and δ-rhythm in others 4 loci, but upregulates the Asymmetry of δ-rhythm, variability of α-rhythm, PSD of θ-rhythm in P3 and O1 loci, Entropy of EEG in T4 as well as Testosterone plasma level. The measure of determination is 54,5%. In postmenopausal women, uricemia downregulates the Amplitude of β-rhythm and its PSD in 8 loci as well as sympathetic tone, but upregulates the PSD of HF and VLF bands HRV, Testosterone plasma level, PSD of θ-rhythm in F3 and O2 loci as well as the Laterality of δ-rhythm. The degree of determination of neuro-endocrine parameters is 94,4%. In women of reproductive age uricemia upregulates the Asymmetry and Amplitude of β-rhythm and its PSD in 6 loci, the Amplitude and Laterality of θ-rhythm and its PSD in F8 locus, as well as the PSD of α-rhythm in F8 locus. The degree of positive determination of EEGs parameters is 95,5%. Conclusion. Plasma uric acid has a modulating effect on neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of adenosine receptors in neurons.

“…Earlier we found that plasma nitrogenous metabolites uric acid, urea and creatinine causes modulating effects on neuro-endocrine parameters, as well as anxiety, but these effects are significantly different in men and women of different ages [4][5][6][7][8]15,19].…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism in relationships between of plasma bilirubin and some neuro-endocrine parameters

Anchev²,

et al. 2022

Background. Earlier we found that plasma uric acid, urea and creatinine causes modulating effects on neuro-endocrine parameters, as well as anxiety, but these effects are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma bilirubin level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of bilirubin and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By building regression models with stepwise exclusion, it was found that in men plasma bilirubin upregulates the variability of β- and α-rhythms as well as PSD of β-rhythm in T4 and Fp2 loci, but downregulates the variability of θ-rhythm, PSD of β-rhythm in P4 and δ-rhythm in T6 loci as well as the trait anxiety. The measure of determination is 42,6% In postmenopausal women, bilirubin downregulates the PSD of β-rhythm in T6 locus, but upregulates the Testosterone plasma level, vagal tone as well as PSD of ULF and VLF bands HRV. The degree of determination of neuro-endocrine parameters is 59,2%. In women of reproductive age bilirubin upregulates the PSD of β-rhythm in T4 locus while downregulates the amplitude of θ- and β-rhythms, PSD of β-rhythm in 5 loci, of α-rhythm in 5 other loci as well as the Entropy of EEG in T5, P4 and C4 loci. The degree of determination of EEGs parameters is 97,8%. Conclusion. Plasma bilirubin has a modulating effect on psycho-neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of Ah receptors in neurons.