Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis

Delay, Lauriane; Santos, Gilson Gonçalves dos; Dias, Elayne Vieira; Yaksh, Tony L.; Corr, Maripat

doi:10.1016/j.rdc.2020.12.006

Cited by 4 publications

(4 citation statements)

References 156 publications

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“…Existing literature has identified sex‐based neurobiological differences in pain perception, which range from the level of transcription in the dorsal root ganglia to differences in cell types important for pain processing in the brain (40). For example, expression of colony stimulating factor 1, a factor important for inducing CNS changes to promote mechanical hypersensitivity, was higher following chronic constriction injury in the dorsal ganglion of female rodents compared to their male counterparts (41).…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis

Vogel

Muhammad

Song

et al. 2023

Arthritis Care & Research

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ObjectiveWomen with rheumatoid arthritis (RA) have higher pain and worse functional outcomes compared to men, even when treated with similar medications. The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST), which are independent of inflammation, in patients with RA.MethodsThis study is a post hoc analysis of participants in the Central Pain in Rheumatoid Arthritis cohort. Pain intensity was assessed using a 0–10 numeric rating scale. Pain interference was measured using a Patient‐Reported Outcomes Measurement Information System computerized adaptive test. QST included pressure pain detection thresholds, temporal summation, and conditioned pain modulation. Women and men were compared using multiple linear regression, adjusted for age, education, race, research site, depression, obesity, RA disease duration, swollen joint count, and C‐reactive protein.ResultsMean ± SD pain intensity was 5.32 ± 2.29 among women with RA, compared to 4.60 ± 2.23 among men with RA (adjusted difference 0.83 [95% confidence interval (95% CI) 0.14, 1.53]). Women with RA had lower pressure pain detection thresholds at the trapezius (adjusted difference –1.22 [95% CI –1.73, –0.72]), wrist (adjusted difference –0.57 [95% CI –1.07, –0.06]), and knee (adjusted difference –1.10 [95% CI –2.00, –0.21]). No statistically significant differences in pain interference, temporal summation, and conditioned pain modulation were observed.ConclusionWomen reported higher pain intensity and lower pressure pain detection thresholds (higher pain sensitivity) than men. However, pain interference, temporal summation, and conditioned pain modulation did not differ between men and women.image

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis

Vogel

Muhammad

Song

et al. 2023

Arthritis Care & Research

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“…Furthermore, this pathology could be underrated due to the different aspecific signs that could affect or be experienced by male or female patients; recent studies showed that the PsA disease phenotype differs between males and females, but further investigation is necessary to fill the gap [35,37]. In particular, several preclinical studies and studies on animal models demonstrate a sexual dimorphism to nociceptive stimuli due to the presence of hormone receptors (estrogen and prolactin) on the dorsal root ganglia, in the fibers innervating joints, and on the central nervous system structures that inhibit and modulate pain perception [38,39].…”

Section: Evaluation Of Eventual Gender Differences In Tmd-psamentioning

confidence: 99%

Psoriatic Arthritis Involving TMJ: A Review on Pathogenesis and Consideration on Eventual Gender Differences

Bernardi,

Memè,

Belfioretti

et al. 2024

Dentistry Journal

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Psoriatic arthritis is defined as chronic inflammatory arthritis associated with psoriasis. The current data regarding gender differences in clinical manifestation and therapeutic outcomes of psoriatic arthritis are limited. Generally, men show a peripheral disease manifestation, while women have an axial distribution of the lesions. If we look at temporomandibular joint (TMJ) involvement, epidemiological data on the involvement of the TMJ are hard to find. Few studies on therapeutic management and the related impact on the quality of life are reported in the literature. Given the morpho-functional peculiarities of the TMJ and the different pain burdens between male and female genders, when manifestation of psoriatic arthritis occurs, clinicians should face it using a multidisciplinary approach for a correct diagnosis and successful treatment. This review aims to examine the diagnostic signs of psoriatic arthritis in the TMJ, the eventual variations of this disease in male and female patients, and the therapeutical strategies. The coordination of different specialties is fundamental to the remission of clinical symptoms and lesion regression.

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“…However, report on the sexual dimorphism in rodent model is mixed. A recent review by Delay et al summarized the arthritis score in the complete Freud’s adjuvant (CFA), the collagen induced arthritis (CIA), the collagen-antibody-induced arthritis (CAIA) and K/BxN (sera from KRN-NOD transgenic mice) passive transfer models [ 17 ]. It reported sex ratio of rats in several studies with controversial results.…”

Section: Main Textmentioning

confidence: 99%

Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds

Dong,

Tian,

et al. 2023

Lab Anim Res

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Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex and limbs accumulated in the past more than two decades from four unique populations of murine arthritis models were analyzed. They are (1) interleukin-1 receptor antagonist (IL-1ra) deficient mice under Balb/c background (Balb/c KO); (2) Mice with collagen II induced arthritis under DBA/1 background; (3) Mice with collagen II induced arthritis under C57BL/6 (B6) background and (4) A F2 generation population created by Balb/c KO X DBA/1 KO. Our data shows that there is a great variation in sexual dimorphism for arthritis incidence and severity of arthritis in mice harboring specific genetic modifications. For a F2 population, the incidence of arthritis was 57.1% in female mice and 75.6% in male mice. There was a difference in severity related to sex in two populations: B6.DR1/ B6.DR4 (P < 0.001) and F2 (P = 0.023) There was no difference Balb/c parental strain or in collagen-induced arthritis (CIA) in DBA/1 mice. Among these populations, the right hindlimbs are significantly higher than the scores for the left hindlimbs in males (P < 0.05). However, when examining disease expression using the collagen induced arthritis model with DBA/1 mice, sex-dimorphism did not reach statistical significance, while left hindlimbs showed a tendency toward greater disease expression over the right. Sexual dimorphism in disease expression in mouse models is strain and genomic background dependent. It sets an alarm that potential variation in sexual dimorphism among different racial and ethnic groups in human populations may exist. It is important to not only include both sexes and but also pay attention to possible variations caused by disease expression and response to treatment in all the studies of arthritis in animal models and human populations.

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Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis

Cited by 4 publications

References 156 publications

Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis

Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis

Psoriatic Arthritis Involving TMJ: A Review on Pathogenesis and Consideration on Eventual Gender Differences

Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds

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