Sexual Dimorphism in the Posterior Pituitary Response to Stress in the Rat*

Williams, T. D. M.; Carter, D. A.; Lightman, Stafford

doi:10.1210/endo-116-2-738

Cited by 140 publications

(66 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Worthington, 1966), as described previously (Eckland et al, 1988). Plasma was stored at -20°C for subsequent AVP measurements by RIA (Rooke & Baylis, 1982;Williams et al, 1985).…”

Section: Animalsmentioning

confidence: 99%

Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant‐induced arthritis

Chowdrey

Larsen

Harbuz

et al. 1995

British J Pharmacology

107

View full text Add to dashboard Cite

1 Adjuvant-induced arthritis (AA) is an experimental inflammation of the joints that results in chronic activation of the hypothalamo-pituitary-adrenal (HPA) axis. 2 In this study the role of hypothalamic corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) in the regulation of the HPA axis in this condition both in Sprague-Dawley (SD), and PiebaldViral-Glaxo (PVG) rats has been further characterized. 3 The increase in AVP peptide content of portal blood (as early as day 11), just prior to the onset of arthritis is confirmed and further increases, peaking at day 16 are shown, coincident with the progression of inflammation in the PVG rats. 4 The increase in AVP is associated with a significant increase in the expression of AVP but not CRF mRNAs in the medial parvocellular division of the hypothalamic paraventricular nucleus (PVN) of arthritic SD rats. 5 In the presence of maximal inflammation of SD rats there was a significant decrease in the maximum binding of ['251]-Tyr-oCRF to anterior pituitary membranes, whereas AVP receptor concentration in anterior pituitary membranes from both PVG and SD rats showed a significant increase with respect to controls. 6 The basal adrenocorticotrophin (ACTH) secretion in vitro was similar in both control and arthritic SD rats but that from arthritic PVG rat pituitaries was significantly greater than the respective controls (436 + 91 v 167 + 23 pg/tube). The ACTH response of pituitaries of arthritic PVG rats to CRF or the combination of CRF and AVP was significantly higher compared with the controls, although the ACTH response of arthritic SD rat pituitaries was unchanged. 7 The results are consistent with the view that activation of the parvocellular vasopressin system has an important role in the adaptation of the HPA axis to experimentally-induced chronic stress of arthritis.

show abstract

“…(Worthington, 1966), as described previously (Eckland et al, 1988). Plasma was stored at -20°C for subsequent AVP measurements by RIA (Rooke & Baylis, 1982;Williams et al, 1985).…”

Section: Animalsmentioning

confidence: 99%

Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant‐induced arthritis

Chowdrey

Larsen

Harbuz

et al. 1995

British J Pharmacology

107

View full text Add to dashboard Cite

show abstract

“…Brattleboro rats, for example, show a stunted brain development [Boer, Swaab, Uylings, Boer, Buijs, & Velis, 1980;Williams, Carter, & Lightman, 1985], and recently Bernroider (1988) …”

mentioning

confidence: 99%

Vasopressin innervation of sexually dimorphic structures of the gerbil forebrain under various hormonal conditions

Crenshaw

Vries

Yahr

1992

J of Comparative Neurology

View full text Add to dashboard Cite

The distribution of vasopressin‐immunoreactive fibers in the forebrain of male and female gerbils was studied, focusing on the lateral septum and the sexually dimorphic area (SDA) found at the border between the medial preoptic area and the anterior hypothalamus. To study hormonal influences on the densities of these fibers, some animals of each sex were gonadectomized or gonadectomized and given testosterone. Others were given sham operations. High densities of vasopressin‐immunoreactive fibers were found in the lateral septum. In the SDA, the densities of these fibers varied considerably. Many were found in the medial half of the medial SDA, but few in the lateral SDA. Vasopressin‐immunoreactive fibers were also sparse in the lateral half of the medial SDA, except for a dense cluster in the SDA pars compacta of males. Similar but smaller clusters were seen in the same location in females although the SDA pars compacta could not be detected in Nissl‐stained sections from the female brains. Fiber densities in two areas, the lateral septum and the lateral SDA, were sensitive to gonadal steroids. In both cases, castration reduced fiber density and testosterone enhanced it. In addition, fiber densities in two areas, the lateral septum and the medial SDA, were sexually dimorphic. In each case, fiber density was greater in males. There was no hormonal effect, however, on the fiber densities in the medial SDA. The fact that the fiber plexuses in the lateral septum and the medial SDA respond differently to gonadal steroids suggests that they arise from different cells and possibly from different areas of the brain. The vasopressin‐immunoreactive fibers in the lateral septum probably come from steroid‐sensitive vasopressin neurons in the bed nucleus of the stria terminalis. Those in the medial SDA may originate in the dorsal aspect of the suprachiasmatic nucleus where vasopressin‐immunoreactive cell bodies were seen. © 1992 Wiley‐Liss, Inc.

show abstract

“…Plasma levels of AVP and ANP were assayed, after extraction, by radioimmunoassay with a lower limit of detection of 05 pmol ml-1 and 35 pmol 1-' respectively (Williams, Carter & Lightman, 1985;Walsh, Williams, Canepa-Anson, Pitts, Lightman & Sutton, 1987).…”

Section: Laboratory Analysesmentioning

confidence: 99%

The cardiovascular, endocrine and renal response of tetraplegic and paraplegic subjects to dietary sodium restriction.

Sutters¹,

Wakefield²,

O’Neil³

et al. 1992

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The effects of change from a high to low sodium diet upon renal sodium and water excretion and hormone responses were studied in patients with dissociated sympathetic control (DS, tetraplegic) and controls with sympathetic control largely intact (IS, paraplegic).2. Total and fractional urinary sodium excretion fell in response to sodium restriction in both groups, but the fall in fractional sodium excretion was greater in the DS group compared with the IS group (DS, 1-34+0-12 to 0-42+0-05%; IS, 0-96+0-08 to 0-52+0-06%).3. Supine mean arterial pressure fell during the low salt period in the DS group (80-2 + 2-7 to 74-4 + 2-3 mmHg) but was unaffected by salt restriction in the IS group (101 + 2-3 to 98-8 + 27 mmHg). In the DS group, creatinine clearance remained constant throughout the low salt period (103-7 + 79 to 98-3 + 97 ml min-), but fell during salt restriction in the IS group (1014 + 8-5 to 832 + 5 ml min-).4. Plasma renin activity was lower during salt loading in DS subjects but increased more rapidly and to higher levels in response to salt restriction (DS, 1021+142 to 4439+355; IS, 1765+269 to 3683+465pg angiotensinIml-1h-1). Plasma atrial natriuretic peptide concentration was higher in the DS group during salt loading and salt restriction (DS, 37-6 + 5-6 to 22 + 3-8; IS, 20-2 + 2-3 to 11 + 1-6 pg ml-').5. These results are consistent with the view that direct sympathetic control of the kidney is not essential for renal sodium conservation in response to dietary salt restriction but is likely to be involved in the haemodynamic and hormonal responses.

show abstract

Sexual Dimorphism in the Posterior Pituitary Response to Stress in the Rat*

Cited by 140 publications

References 7 publications

Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant‐induced arthritis

Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant‐induced arthritis

Vasopressin innervation of sexually dimorphic structures of the gerbil forebrain under various hormonal conditions

The cardiovascular, endocrine and renal response of tetraplegic and paraplegic subjects to dietary sodium restriction.

Contact Info

Product

Resources

About