2016
DOI: 10.1155/2016/8423192
|View full text |Cite
|
Sign up to set email alerts
|

Sexual Dimorphism in the Regulation of Estrogen, Progesterone, and Androgen Receptors by Sex Steroids in the Rat Airway Smooth Muscle Cells

Abstract: The role of sex hormones in lung is known. The three main sex steroid receptors, estrogen, progesterone, and androgen, have not been sufficiently studied in airway smooth muscle cells (ASMC), and the sex hormone regulation on these receptors is unknown. We examined the presence and regulation of sex hormone receptors in female and male rat ASMC by Western blotting and flow cytometry. Gonadectomized rats were treated with 17β-estradiol, progesterone, 17β-estradiol + progesterone, or testosterone. ASMC were enzy… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
5
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 9 publications
(6 citation statements)
references
References 41 publications
0
5
0
Order By: Relevance
“…Indeed, in contrast to the kidney, pulmonary Gilz mRNA expression, for instance, is upregulated to a greater degree in females compared to males. Recent studies have underlined sex differences in respiratory function during lung development and in adulthood [ 3 , 53 , 54 , 55 ]. Moreover, female smokers have an increased risk of chronic obstructive pulmonary disease in comparison to male smokers with similar history of cigarette smoke exposure, both in human and mice; however, the underlying mechanisms are still under investigation [ 56 , 57 ].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in contrast to the kidney, pulmonary Gilz mRNA expression, for instance, is upregulated to a greater degree in females compared to males. Recent studies have underlined sex differences in respiratory function during lung development and in adulthood [ 3 , 53 , 54 , 55 ]. Moreover, female smokers have an increased risk of chronic obstructive pulmonary disease in comparison to male smokers with similar history of cigarette smoke exposure, both in human and mice; however, the underlying mechanisms are still under investigation [ 56 , 57 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is also important to consider whether and how progesterone influences ASM with limited data of effects on the airway function (200,213,239,514). A similar question can be raised regarding whether testosterone, acting via androgen receptors, is bronchodilatory or protective as suggested by some studies (77,80,81,283,284,410) and whether differences in receptor regulation between men vs. women play a role (284,585). Overall, these many unanswered questions represent another important area for investigation in airway disease, particularly the role of ASM.…”
Section: L1123mentioning
confidence: 99%
“…5 β -DHT, the other reduced metabolite of T, possesses minor androgenic activity due to a lower binding affinity than 5 α -DHT [ 50 ]. The AR is expressed in several mammalian tissues, including vascular and airway smooth muscles and cardiac myocytes [ 2 , 51 56 ]. Furthermore, the activity of the AR has been implicated in cardiovascular and respiratory ailments such as vascular ischemia [ 53 ], hypertension [ 57 , 58 ], asthma [ 52 ], and cardiac hypertrophy [ 54 ].…”
Section: Introductionmentioning
confidence: 99%