Sexual Dimorphism of Hepatocellular Carcinoma in Pakistan

Sohail, Zaineb; Afzal, Muhammad Sohail

doi:10.4172/1948-5964.1000171

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…It is the most common and primary type of liver cancer. (1) HCC, estimated to account for 5% of all malignant tumours worldwide, is the sixth most frequent malignancy and the third leading cause of cancer-related fatalities. HCC incidence is expected to have reached its highest by 2030.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma: A Cross-Sectional Analysis of Risk Factors

Bandesha,

Anwar,

Rehan

et al. 2023

PJMHS

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Background Hepatocellular carcinoma is the most prevalent primary liver cancer globally and the major cause of cancer-associated deaths. Method: A cross-sectional study was carried out at CMH Multan's Department of Histopathology. The individuals with HCC presented to CMH Multan's OPD or indoor general medicine department were selected. Informed consent was obtained. On a standardised proforma, all information such as gender, age groups, residence status, family history, diabetes, smoking, hypertension, and obesity was entered and analysed using the latest version of the SPSS. Results: 85 (67.5%) of the 126 study cases were male, whereas 41 (32.5%) were female. 72 (57.1%) were from metropolitan areas, while 54 (42.9%) were from rural areas. Smoking was found in 10 (7.9%), and diabetes was found in 43. (34.1%). Obesity was found in 18 (14.3%), and hypertension was present in 74 (58.7%). Only 5 (4%) of our study cases had a family history of HCC. Conclusion: HCC is more common in male patients, older patients, urban patients, and patients with diabetes, hypertension, and obesity. Individuals with diabetes, hypertension, and obesity undergo screening for HCC regularly. Further research is necessary to recognise the environmental and genetic variables that could contribute to developing HCC in various environments and populations. Keywords: Liver, Risk factors, Hepatocellular carcinoma, Liver neoplasms.

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Section: Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma: A Cross-Sectional Analysis of Risk Factors

Bandesha,

Anwar,

Rehan

et al. 2023

PJMHS

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Bioinformatics and Experimental Insights Into miR‐182, hsa_circ_0070269, and circ‐102,166 as Therapeutic Targets for HCV‐Associated HCC

Ishaq,

Rauff,

Alzahrani

et al. 2024

Cancer Reports

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AimsHepatocellular carcinoma (HCC) is a type of malignant tumor and the sixth leading cause of death worldwide. It is caused by HBV, HCV infection, and alcohol consumption. MicroRNAs are typically small, non‐coding RNAs that are involved in the regulation of mRNA expression. Recent studies revealed miRNAs' regulatory roles in liver cancer, linked to risk factors like HCV, HBV infection, alcoholism, drug use, and auto‐immune hepatic disorders. Circular RNAs also belong to the class of non‐coding RNAs; they act as ceRNAs to regulate miRNA expression and regulate different oncogenic pathways in HCC progression. This study aimed to check the hsa_circ_0070269, circ‐102,166 (hsa_circ_0004913), and miR‐182 expression in HCV induced HCC patients.MethodsData analysis was used to find out studies related to the role of hsa_circ_0070269, circ‐102,166, and miR‐182 in HCC; miR‐182 targeted genes, their role in different diseases; and miR‐182 interactions with hsa_circ_0070269 and circ‐102,166 in the HCC. It was revealed that the hsa_circ_0070269, circ‐102,166, and miR‐182 correlations in HCV induced HCC have not been explored yet. Therefore, to validate data from literature mining, expression analysis of dysregulated hsa_circ_0070269, circ‐102,166, and miR‐182 was performed in HCV induced HCC patients using RT‐PCR.ResultsIt was found that miR‐182 was significantly upregulated and acts as an oncomiRNA in HCV induced HCC, and hsa_circ_0070269 and circ‐102,166 were downregulated in HCV induced HCC. We have identified that miR‐182 relative expression level was significantly high (p < 0.0029), while has_circ_0070269 (p < 0.002) and circ‐102,166 (p < 0.002) were significantly downregulated in HCV‐HCC patients as compared to expression in healthy individuals.ConclusionOur data revealed that miR‐182 acts as an oncomiRNA in HCC development. Hsa_circ_0070269 and circ‐102,166 are highly expressed in healthy controls compared to HCV induced HCC patients, can sponge miR‐182 expression by acting as tumor suppressors, and can be used as biomarkers and targets for HCC treatment.

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Sexual Dimorphism of Hepatocellular Carcinoma in Pakistan

Cited by 2 publications

References 18 publications

Hepatocellular Carcinoma: A Cross-Sectional Analysis of Risk Factors

Hepatocellular Carcinoma: A Cross-Sectional Analysis of Risk Factors

Bioinformatics and Experimental Insights Into miR‐182, hsa_circ_0070269, and circ‐102,166 as Therapeutic Targets for HCV‐Associated HCC

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