Sexual dimorphism of heritability of immunoglobulin levels

Kacprzak-Bergman, I

doi:10.1080/03014469400003562

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…Cryptococcosis was more common among men in the pre-AIDS era than among women (13) and in several cohorts of HIV-infected individuals in the United States and France than among Ugandans (26,29,34). Interestingly, higher levels of immunoglobulin have been reported among females than among males (38,55). Women comprised 67% of the cohort in our study, but there were no differences in antibody levels based on gender in our adjusted analyses.…”

Section: Deficiency Of Cd27contrasting

confidence: 36%

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Subramaniam¹,

French

Pirofski

2005

Clin Vaccine Immunol

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We determined total and Cryptococcus neoformans glucuronoxylomannan (GXM)-reactive antibody repertoires of human immunodeficiency virus (HIV)-infected and HIV-uninfectedThe results showed that HIV-infected subjects had significantly lower levels of IgM to GXM but higher levels of total immunoglobulin and IgG and IgA to GXM than those of HIV-uninfected subjects. HIV-infected subjects with a history of pneumonia had higher levels, and those with a history of herpes zoster had lower levels of GXM-binding antibodies than subjects with no history of either disease. Minimal to no cross-reactivity was demonstrated between antibodies to GXM and polysaccharides in a pneumococcal vaccine. No significant differences between the antibody repertoires of HIV ؉ CM ؉ and HIV ؉ CM ؊ subjects were identified, but among subjects without a history of pneumonia, there was a trend towards lower V H 3-positive antibody levels among HIV ؉ CM ؉ than among HIV ؉ CM ؊ subjects. Our findings demonstrate an association between previous infectious diseases and differences in the total and GXM-reactive antibody repertoires of HIV-infected subjects and suggest the question of whether certain microbes modulate subsequent antibody responses to GXM deserves further study.

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Section: Deficiency Of Cd27contrasting

confidence: 36%

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Subramaniam¹,

French

Pirofski

2005

Clin Vaccine Immunol

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“…In this field, enormous studies have been conducted. [6,7] Results for IgA and IgG levels are similar in both sexes, but for IgM levels, it has been observed that, in females, the IgM level is higher than in male subjects, [23,26] and some studies found a relationship between number of X chromosomes and IgM concentration. [8,21,22] In most sciences, such as immunology, an approved, authoritative, global standard reference interval has been prepared which is profitable in laboratory and clinical tests.…”

Section: Discussionmentioning

confidence: 99%

Normal Value of Immunoglobulins IgA, IgG, and IgM in Iranian Healthy Adults, Measured by Nephelometry

Kardar

Shams

Pourpak

et al. 2003

Journal of Immunoassay and Immunochemistry

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Local reference ranges of immunoglobulins are required for studies and clinical interpretation. In this study, serum levels of IgA, IgG, and IgM in 914 Iranian healthy adult blood donor volunteers, aged 18-55 years, were measured by nephelometry. Our data showed that serum reference intervals of IgA, IgG, and IgM in subjects were 72-375, 636-1518, and 39-283 mg/dL, respectively. Data analysis showed a significant difference between the male and female subjects only for IgM; thus, the means of IgM in females were higher than for males (p < 0.05). Correlation coefficient r for paired samples showed no statistically significant relationship between age and each Ig (p > 0.05). Comparison of this study with others demonstrated that results are similar; some differences are probably related to ethnic differences. Therefore, our results can be considered as a source of reliable local reference for use in laboratories.

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“…This parallels the observed male predominance in the literature. However, also among healthy controls low IgM levels are more common in males [18][19][20][21], and there are some reports of low serum IgM levels among fathers of patients [22,23]. It would be of interest to investigate this gender difference further.…”

Section: Selective Igm Deficiencymentioning

confidence: 99%

Truly selective primary IgM deficiency is probably very rare

Janssen

Macken

Creemers

et al. 2017

Clinical and Experimental Immunology

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Isolated decreased serum-immunoglobulin (Ig)M has been associated with severe and/or recurrent infections, atopy and autoimmunity. However, the reported high prevalence of clinical problems in IgM-deficient patients may reflect the skewed tertiary centre population studied so far. Also, many papers on IgM deficiency have included patients with more abnormalities than simply IgM-deficiency. We studied truly selective primary IgM deficiency according to the diagnostic criteria of the European Society for Immunodeficiencies (ESID) (true sIgMdef) by reviewing the literature (261 patients with primary decreased serum-IgM in 46 papers) and analysing retrospectively all patients with decreased serum-IgM in a large teaching hospital in 's-Hertogenbosch, the Netherlands [1 July 2005-23 March 2016; n = 8049 IgM < 0·4 g/l; n = 2064 solitary (IgG+IgA normal/IgM < age-matched reference)]. A total of 359 of 2064 (17%) cases from our cohort had primary isolated decreased serum-IgM, proven persistent in 45 of 359 (13%) cases; their medical charts were reviewed. Our main finding is that true sIgMdef is probably very rare. Only six of 261 (2%) literature cases and three of 45 (7%) cases from our cohort fulfilled the ESID criteria completely; 63 of 261 (24%) literature cases also had other immunological abnormalities and fulfilled the criteria for unclassified antibody deficiencies (unPAD) instead. The diagnosis was often uncertain (possible sIgMdef): data on IgG subclasses and/or vaccination responses were lacking in 192 of 261 (74%) literature cases and 42 of 45 (93%) cases from our cohort. Our results also illustrate the clinical challenge of determining the relevance of a serum sample with decreased IgM; a larger cohort of true sIgMdef patients is needed to explore fully its clinical consequences. The ESID online Registry would be a useful tool for this.

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Sexual dimorphism of heritability of immunoglobulin levels

Cited by 12 publications

References 11 publications

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Cryptococcus neoformans -Reactive and Total Immunoglobulin Profiles of Human Immunodeficiency Virus-Infected and Uninfected Ugandans

Normal Value of Immunoglobulins IgA, IgG, and IgM in Iranian Healthy Adults, Measured by Nephelometry

Truly selective primary IgM deficiency is probably very rare

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