Sexual dimorphism of the fetal brain biometry: an MRI-based study

Gafner, Michal; Sade, Eliel Kedar; Katorza, E.

doi:10.1007/s00404-022-06818-4

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Interpretation of missing values in US images must consider that non-pathological screening brain ultrasounds may lack targeted CC images. Gender impact was not assessed, as sexual dimorphism’s effect on fetal CC remains uncertain, with studies showing both influence ( 28 ) and lack thereof ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging

Lamon,

de Dumast,

Sanchez

et al. 2024

Front. Neurol.

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ObjectiveTo assess the accuracy of corpus callosum (CC) biometry, including sub-segments, using 3D super-resolution fetal brain MRI (SR) compared to 2D or 3D ultrasound (US) and clinical low-resolution T2-weighted MRI (T2WS).MethodFetal brain biometry was conducted by two observers on 57 subjects [21–35 weeks of gestational age (GA)], including 11 cases of partial CC agenesis. Measures were performed by a junior observer (obs1) on US, T2WS and SR and by a senior neuroradiologist (obs2) on T2WS and SR. CC biometric regression with GA was established. Statistical analysis assessed agreement within and between modalities and observers.ResultsThis study shows robust SR to US concordance across gestation, surpassing T2WS. In obs1, SR aligns with US, except for genu and CC length (CCL), enhancing splenium visibility. In obs2, SR closely corresponds to US, differing in rostrum and CCL. The anterior CC (rostrum and genu) exhibits higher variability. SR’s regression aligns better with literature (US) for CCL, splenium and body than T2WS. SR is the method with the least missing values.ConclusionSR yields CC biometry akin to US (excluding anterior CC). Thanks to superior 3D visualization and better through plane spatial resolution, SR allows to perform CC biometry more frequently than T2WS.

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Section: Discussionmentioning

confidence: 99%

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging

Lamon,

de Dumast,

Sanchez

et al. 2024

Front. Neurol.

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“…Based on previous work by Gafner et al, which showed that there is no statistically significant difference in the TCD and in the length of CC between the different sexes [19], we performed the analysis on all cases without dividing into groups based on fetal sex.…”

Section: Discussionmentioning

confidence: 99%

Agreement between Fetal Brain Ultrasonography and Magnetic Resonance Imaging in the Measurements of the Corpus Callosum and Transverse Cerebellar Diameter

Bookstein,

Nachmias,

Katorza

2024

Diagnostics

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As the use of magnetic resonance imaging of the fetal brain has evolved, the need to understand its efficiency in the biometry of the fetal brain has broadened. This study aimed to assess the level of agreement and correlation between the two cardinal imaging methods of fetal neuroimaging, ultrasonography (US) and magnetic resonance imaging (MRI), by measuring the corpus callosum (CC) and transverse cerebellar diameter (TCD) in terms of length and percentile. Measurements of CC and TCD length and percentile were documented over a 7-year span in a tertiary referral medical center. All US and MRI examinations were performed in the customary planes and subcategorized by valid reference charts. Exclusion and inclusion criteria were set before the collection and processing of the data. A total of 156 fetuses out of 483 were included in the study. A positive, strong correlation and agreement were found (r = 0.78; ICC = 0.76) between US and MRI in TCD measurements. For CC length measurement, a moderate correlation and moderate agreement (r = 0.51; ICC = 0.49) between US and MRI was observed. TCD and CC percentiles had lower levels of correlation and agreement compared with the length variables. Our study indicates good agreement between MRI and US in the assessment of TCD measurement as a part of antenatal neuroimaging. Furthermore, while the two techniques are not always compatible, they are complementary methods.

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“…Moreover, the ratio of missing values in US images must be interpreted with caution as patients with a screening brain ultrasound that was not pathological do not necessarily have targeted CC images. Finally, gender effect was not evaluated but sexual dimorphism on fetal CC is still unclear, with studies that did (24) and did not show impact of gender (46).…”

Section: Limitationsmentioning

confidence: 99%

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

Lamon,

de Dumast,

Dunet

et al. 2023

Preprint

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Objective: To assess the accuracy of corpus callosum (CC) and its sub-segments' biometry by super-resolution (SR) 3-dimensional fetal brain MRI in comparison to measurements in 2-dimensional or 3-dimensional ultrasonography (US) and clinical low-resolution T2-weighted MRI sequences (T2WS). Method: We performed fetal brain biometry of the overall length of the CC, the heights of its sub-segments and its area by two observers (one junior observer, obs1, and one senior pediatric neuroradiologist, obs2) in a cohort of 57 subjects (between 21 and 35 weeks of gestational age (GA), including 11 cases of partial agenesis of CC). Obs1 made measures on US, T2WS, and SR, and obs2 in T2WS and SR. Regression curves of CC biometry with GA were done. Statistical analysis of inter-modality (US vs. T2WS, US vs. SR, and T2WS vs SR) agreement for single observer (obs1) and inter-modality (US vs. T2WS, and US vs. SR) between observers (obs1 vs obs2) were also conducted. Results: Our study shows a high concordance through GA of CC measurements performed by SR in comparison with US, with a higher agreement than biometry based on T2WS clinical acquisitions. For obs1, SR measurements are highly concordant to US (except for the genu and the CC length) and helps visualizing the splenium. For obs2, SR measurements are highly concordant to US, except for the rostrum and the CC length. Rostrum and Genu (forming the anterior callosum) are the subsegments with larger variability. Regression curves by SR overlay more accurately those from the literature (by US) for the CC length, the splenium and the body than T2WS. Conclusion: Super-resolution MRI could be used in the biometrical assessment of the CC, providing measurements close to US, except for the anterior part of the CC Thanks to its 3D-visualisation capacity and improved through plane spatial resolution, it allows to perform CC biometry more frequently than on T2WS.

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Sexual dimorphism of the fetal brain biometry: an MRI-based study

Cited by 4 publications

References 26 publications

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging

Agreement between Fetal Brain Ultrasonography and Magnetic Resonance Imaging in the Measurements of the Corpus Callosum and Transverse Cerebellar Diameter

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted MRI

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