Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Linares‐González, Laura; Lozano-Lozano, Ignacio; Gutiérrez‐Rojas, Luis; Lozano‐Lozano, Mario; Ródenas‐Herranz, Teresa; Ruiz‐Villaverde, Ricardo

doi:10.3390/life11121314

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…Somewhat surprisingly, the situation with genital herpes was reversed: patients with severe AD had significantly fewer genital HSV symptoms. We hypothesize that this could be explained by sexual dysfunction associated with severe AD (25), leading to a smaller number of sexual partners. This hypothesis is, however, challenged by the opposite finding regarding the risk of condylomas.…”

Section: Discussionmentioning

confidence: 99%

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

Kiiski¹,

Ukkola-Vuoti²,

Vikkula³

et al. 2023

Acta Derm Venereol

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The majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from both primary and specialty healthcare registries covering the entire Finnish adult population. In total, 124,038 patients were identified (median age 46 years; 68% female) and stratified by disease severity. All regression analyses (median follow-up 7.0 years) were adjusted at a minimum for age, sex, obesity, and educational level. Compared with mild atopic dermatitis, severe atopic dermatitis was significantly associated with multiple morbidities, including neurotic, stress-related and somatoform disorders, abscesses, erysipelas/cellulitis, impetigo, herpes zoster, extragenital herpes, bacterial conjunctivitis, septicaemia, lymphomas, alopecia areata, urticaria, other dermatitis, contact allergy, osteoporosis, and intervertebral disc disorders (p < 0.001). In addition, there were significant associations with alcohol dependence, depression, condylomas, rosacea, migraine, sleep apnoea, hypertension, enthesopathies, atherosclerosis, and drug-induced cataract (p < 0.05). Odds ratios were modest and mostly were between 1.10 and 2.75. Furthermore, patients with severe atopic dermatitis had lower incidences of prostate cancer, cystitis, and anogenital herpes than patients with mild atopic dermatitis (p < 0.05). These results suggest that severe atopic dermatitis results in significant overall morbidity.

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Section: Discussionmentioning

confidence: 99%

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

Kiiski¹,

Ukkola-Vuoti²,

Vikkula³

et al. 2023

Acta Derm Venereol

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“…A few studies have addressed the sexual life of patients with AD, but most of them have focused mainly on male sex ( 18 , 23 , 24 ). One Dutch study with a small sample size found that sexual satisfaction and self-perception of appearance in women with AD is significantly lower than in general populations.…”

Section: Discussionmentioning

confidence: 99%

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

Fougerousse,

Alexandre,

Darrigade

et al. 2024

Acta Derm Venereol

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Atopic dermatitis (AD) is one of the most common inflammatory diseases, and has a higher prevalence among females in adulthood. The aim of this observational, cross-sectional, survey-based study was to evaluate the impact of AD on the daily lives of adult women patients. A scientific committee composed exclusively of women constructed a specific questionnaire in partnership with the French Eczema Association. Severity of AD was evaluated with the Patient-Oriented Eczema Measure (POEM). A sample of 1,009 adult women (mean age ± standard deviation: 41.8 ± 14.2 years) with AD was identified from a representative sample of the French population (82% response rate 1,230 women surveyed). According to the POEM, 50.64% (n = 511) of subjects were identified as having mild AD, 39.35% (n = 397) moderate AD, and 10.01% (n = 101) severe AD. Overall, 67.7% (n = 682) reported that their eczema involved a visible area (face, neck or hands), and 19.6% (n = 198) a sensual area (breasts/chest, genital area or buttocks). Of the 720 women with menstrual cycles, exacerbations of AD were reported to occur mostly before (50.6%) and during (48.3%) menstruation. A small proportion of women, 7.3% (n = 74), reported being afraid of becoming pregnant because of their eczema. If AD involvement was in a visible area it had a greater impact on romantic relationships, sexual relationships and occupation. If AD involvement was in a sensual area it had a greater influence on romantic relationships and sexuality. Particular attention should be given to patients with localization of AD on the face, neck or hands, as they have a higher risk of social exclusion. Moreover, these results should encourage health professionals to ask patients with AD about the possible involvement of sensual areas.

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“…In our endeavor to investigate the connection between allergic conditions and SD, several studies revealed a positive correlation between better asthma control and higher FSFI and IIEF scores, while patients with allergic rhinitis and rhinoconjunctivitis demonstrated significantly lower FSFI or IIEF scores. CSU and atopic dermatitis [96, 97] have also been associated with increased risk of SD.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Allergic Disease and Sexual Dysfunction: A Scoping Review

Chiang,

Lee,

Chien

et al. 2023

Int Arch Allergy Immunol

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Introduction: Sexual dysfunction (SD) and allergic disease are common health concerns worldwide and bear a potential relationship. This scoping review is conducted to analyze the currently available data regarding the associations between these two health issues. Methods: A comprehensive literature search was performed in the databases of PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to retrieve studies that were published before January 2023. A narrative synthesis was conducted to analyze the effects of allergic diseases on SD based on the evaluation of the Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF). Results: Twelve observational studies were included after the selection process. The results generally suggested lower FSFI or IIEF scores in patients with asthma, allergic rhinitis, allergic rhinoconjunctivitis, and urticaria compared to the healthy control groups. The underlying factors of this relationship could be inflammation, psychological factors, hormonal changes, sleep disorders, sexual behavior-related allergic reactions, social economic status, and the use of medications. Conclusion: SD and allergic disease are interrelated based on the extant literature. This scoping review provides insights into the clinical implications of both entities, while more research studies are warranted to further elucidate this complex relationship.

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Sexual Dysfunction and Atopic Dermatitis: A Systematic Review

Cited by 13 publications

References 48 publications

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults

Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women

The Relationship between Allergic Disease and Sexual Dysfunction: A Scoping Review

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