Sexual Dysfunction in Parkinson Disease: A Multicenter Italian Cross-sectional Study on a Still Overlooked Problem

Raciti, Loredana; Cola, Maria Cristina De; Ortelli, Paola; Corallo, Francesco; Buono, Viviana Lo; Morini, Elisabetta; Quattrini, Fabrizio; Filoni, Serena; Calabrò, Rocco Salvatore

doi:10.1016/j.jsxm.2020.06.010

Cited by 34 publications

(50 citation statements)

References 69 publications

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“…However, about 57% of the patients stated that the disease affected their sexual life, especially due to reduced sexual desire, and the frequency of sexual intercourses. As it was reasonable to expect, also in this cohort of patients there was an impact of NMS on the QoL in PD patients [ 16 ].…”

Section: Resultsmentioning

confidence: 80%

Sex Differences in Parkinson’s Disease: From Bench to Bedside

et al. 2022

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Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences in PD regarding biomarkers, genetic factors, motor and non-motor symptoms, therapeutic management (including pharmacological and surgical treatment) as well as preclinical studies. Methods: A systematic literature review was performed by searching the Pubmed and Scopus databases with the search strings “biomarkers’’, ‘‘deep brain stimulation’’, “female”, ‘‘gender’’, ‘‘genetic”, ‘‘levodopa’’, ‘‘men’’, “male”, ‘‘motor symptoms’’, ‘‘non-motor symptoms’’, ‘‘Parkinson disease’’, ‘‘sex’’, ‘‘surgery’’, and ‘‘women’’. Results: The present review confirms the existence of differences between men and women in Parkinson Disease, pointing out new information regarding evidence from animal models, genetic factors, biomarkers, clinical features and pharmacological and surgical treatment. Conclusions: The overall goal is to acquire new informations about sex and gender differences in Parkinson Disease, in order to develop tailored intervetions.

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Section: Resultsmentioning

confidence: 80%

Sex Differences in Parkinson’s Disease: From Bench to Bedside

et al. 2022

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“…SD is a frequent but still underrated non-motor symptom of PD [ 12 , 14 , 23 , 24 , 25 ]. Various studies have shown that SD occurs significantly more often in patients with PD than in healthy controls [ 13 , 16 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…While the prevalence of NMS in PD is estimated to affect every other PD patient [ 51 , 52 ], the prevalence of SD might be even higher because of the intimacy of this topic and the embarrassment to address this issue. Yet, NMS including SD are still underappreciated in the treatment of PD patients [ 23 , 24 , 53 ], since the clinical focus usually lies in the assessment and therapy of the obvious and objectifiable motor symptoms of PD. The results of this study underline the importance of systematically assessing SD in clinical routine.…”

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunctions in Parkinson’s Disease and Their Influence on Partnership—Data of the PRISM Study

et al. 2022

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Background: Sexual dysfunctions (SD) are common but underreported in Parkinson’s disease (PD) and have negative impacts on the quality of life (QoL) and partnership. Methods: We analyzed the data set from the PRISM study for demographics of SD and their influence on quality of life and partnership. Results: 449/861 (52.1%) PD patients reported SD, with male patients being affected more often and having a longer course of disease. The most common SD in men was erectile dysfunction (ED) (n = 152), while women’s most frequent complaints were orgasm dysfunction (n = 84) and reduced libido (n = 81). Hypersexual SDs were reported significantly more often by men. Spousal caregivers of patients reporting inability to relax and enjoy sex and reduced libido indicated a negative influence on the relationship in general. Negative effects on the sexual relationship were reported significantly more often for patients with ED, difficulties with sexual arousal, inability to relax and enjoy sex, and reduced libido. Hypersexual dysfunctions showed no effect on the relationship. Conclusion: SD is a common but underreported problem in the treatment of patients with PD. Due to the negative influence on the relationship and QoL of patients and caregivers, SD should be assessed routinely.

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“…There are relatively few studies on sexual dysfunction in PD. At present, studies have reported that PD patients are more likely to suffer from sexual dysfunction than normal people 46,47 . In our study, we found that sexual dysfunction is an independent predictor of N-CI in PD patients, and sexual dysfunction is a protective factor for dementia in patients with cognitive impairment (OR=0.350).…”

Section: Discussionmentioning

confidence: 94%

Transcranial Sonography with Clinical and Demographic Characteristics to Predict Cognitive Impairment in PD: A Longitudinal Study

Zhang

et al. 2021

Preprint

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Background Parkinson’s disease (PD) is a neurodegenerative disease second only to Alzheimer’s disease and is clinically characterized by a series of motor and non-motor symptoms. The latter often appear before motor symptoms, while cognitive impairment mostly occurs within a few years after the diagnosis of PD. We Aimed to predict the risk factors of cognitive impairment in PD patients based on transcranial sonography, clinical symptoms, and demographic characteristics. Independent-sample t-test was used for continuous data, and chi-square test was used for countable data. According to the occurrence time of cognitive impairment (CI), 172 PD patients were divided into non-CI (N-CI, n=48), CI at the first treatment (F-CI, n=58), and CI at the last treatment (L-CI, n=66). The age of onset, first treatment and smoking history of CI patients were significantly different from those with N-CI. When age of first treatment ≥61 years was considered the boundary value to diagnose CI, the sensitivity and specificity were 77.40% and 66.70%, respectively. At the first treatment, there was significant difference in depression between F-CI and N-CI. At the last treatment, the cumulative and new or aggravated hypomnesia of L-CI was significantly more than that of N-CI. There was significant difference in TCS grading between the first- and last treatment in L-CI. Depression, sexual dysfunction, and olfactory dysfunction were independent risk factors for CI during the last treatment, while memory impairment was an independent risk factor for CI during the entire treatment. The sensitivity and specificity of predicting CI in PD patients were 81.80% and 64.60%, respectively. The older the age of onset and treatment of PD patients, the more likely they were to have CI. Hypomnesia, depression, sexual dysfunction, and olfactory dysfunction can be used as independent risk factors to predict CI in PD patients.

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Sexual Dysfunction in Parkinson Disease: A Multicenter Italian Cross-sectional Study on a Still Overlooked Problem

Cited by 34 publications

References 69 publications

Sex Differences in Parkinson’s Disease: From Bench to Bedside

Sex Differences in Parkinson’s Disease: From Bench to Bedside

Sexual Dysfunctions in Parkinson’s Disease and Their Influence on Partnership—Data of the PRISM Study

Transcranial Sonography with Clinical and Demographic Characteristics to Predict Cognitive Impairment in PD: A Longitudinal Study

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