Sexual Dysfunction in Parkinsonʼs Disease

Koller, William C.; Vetere-Overfield, Bridget; Williamson, Annette; Busenbark, Karen; Nash, Jim; Parrish, David D.

doi:10.1097/00002826-199010000-00008

Cited by 89 publications

(43 citation statements)

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“…SD is common in patients with PD [Hand et al 2010;Celikel et al 2008;Bronner et al 2004;Jacobs et al 2000;Zesiewicz et al 2000;Welch et al 1997;Wermuth and Stenager, 1995;Brown et al 1990;Koller et al 1990], associated with depression and relationship dissatisfaction [Wielinski et al 2010]. SD has been reported as common even in young patients with PD (mean age 49.6 years).…”

Section: Introductionmentioning

confidence: 99%

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Management of sexual dysfunction in Parkinson’s disease

Bronner¹,

Vodušek²

2011

Ther Adv Neurol Disord

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Nonmotor symptoms, among them sexual dysfunction, are common and underrecognized in patients with Parkinson disease; they play a major role in the deterioration of quality of life of patients and their partners. Loss of desire and dissatisfaction with their sexual life is encountered in both genders. Hypersexuality (HS), erectile dysfunction and problems with ejaculation are found in male patients, and loss of lubrication and involuntary urination during sex are found in female patients. Tremor, hypomimia, muscle rigidity, bradykinesia, 'clumsiness' in fine motor control, dyskinesias, hypersalivation and sweating may interfere with sexual function. Optimal dopaminergic treatment should facilitate sexual encounters of the couple. Appropriate counselling diminishes some of the problems (reluctance to engage in sex, problems with ejaculation, lubrication and urinary incontinence). Treatment of erectile dysfunction with sildenafil and apomorphine is evidence based. HS or compulsive sexual behaviour are side effects of dopaminergic therapy, particularly by dopaminergic agonists, and should be treated primarily by diminishing their dose. Neurologists should actively investigate sexual dysfunction in their Parkinsonian patients and offer treatment, optimally within a multidisciplinary team, where a dedicated professional would deal with sexual counselling.

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Section: Introductionmentioning

confidence: 99%

“…Inability to maintain an erection has been found in half of the males [Wermuth and Stenager, 1995;Koller et al 1990]. ED was reported by 54-79% of men with PD [Bronner et al 2004;Sakakabira et al 2001;Koller et al 1990]. A total of 60% of men with PD reported ED, as compared with 37.5% in age-matched controls [Singer et al 1991].…”

Section: Introductionmentioning

confidence: 99%

Management of sexual dysfunction in Parkinson’s disease

Bronner¹,

Vodušek²

2011

Ther Adv Neurol Disord

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“…However, a study investigating 50 parkinsonian male and female patients reported that a high percentage of these patients had a loss of sexual interest and functioning [60]. Depression was not prevalent but 70% had some evidence of autonomic nervous system dysfunction that may be related to the sexual dysfunction.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Urological Aspects of Female Sexual Dysfunction

Khan

Thompson²,

Mumtaz³

et al. 2000

Urol Int

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The aetiology of male sexual dysfunction has been extensively investigated over the past few decades. This has led to the development of effective treatment for this common problem. However, to date, female sexual dysfunction has received very little attention, particularly from a urological point of view. In this review, we discuss the anatomy and physiology of the female sexual organs as well as the aetiological factors that are associated with female sexual dysfunction. An improved awareness and understanding of this subject may, in the future, enable us to address female sexual dysfunction more appropriately and develop suitable treatment.

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“…Clinically, it is noteworthy that depression (Mayeux et al, 1981;Huber et al, 1988;Schiffer et a1.,1988), anxiety states (Stein et al, 1990), pain (Snider & Sandyk, 1987), anorexia and weight loss (Van der Linden et al, 1985;Paulson, 1986), sexual dysfunction (Singer et al, 1989;Lipe et al, 1990;Koller et al, 1990), and sleep disturbances (Kales et al, 1971;Nausieda et al, 19826;Lees et al, 1988) are common and often distressing symptoms in PD and only rarely improve or abate with anticholinergic agents or levodopa therapy (Paulson, 1986). The alerting effect reported by the patients after the application of weak magnetic fields is especially intriguing since hypoarousal has been suggested to contribute to the expression of the hypokinesia and dementia of Parkinsonism (Heilman et al, 1978;Villardita et al, 1983;Stern et al, 1984;Heilman et al, 1985;Girotti et al, 1986).…”

Section: Proposed Mode Of Action Of Magnetic Fieldsmentioning

confidence: 99%