Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis

Santana, Larissa Marques; Perin, L; Lunelli, Rosana Pinheiro; Inácio, José Francisco Secorun; Rodrigues, Clarissa Garcia; Eibel, Bruna; Goldmeier, Sílvia

doi:10.1007/s11906-019-0925-z

Cited by 27 publications

(34 citation statements)

References 29 publications

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“…Hypertension and/or antihypertensive medication have also been associated with SD. A recent meta-analysis revealed considerable heterogeneity in the literature, with the prevalence of SD in hypertensive women varying between 14.1 to 90.1% [68]. Furthermore, it was acknowledged in a systematic review [69] and the Third National Survey of Sexual Attitudes and Lifestyles [70] that hypertensive women exhibited higher prevalence of SD than normotensive women.…”

Section: Sd and Comorbiditiesmentioning

confidence: 99%

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Chou

Kiebalo

Jagiello

et al. 2021

Life

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Patient survival continues to increase with the growing quality of dialysis and management of chronic kidney disease (CKD). As such, chronic therapy must include considerations of quality of life (QOL), and this includes the disproportionate prevalence of sexual dysfunction (SD) in this patient population. This review aims to describe the pathophysiological and the psychosocial causes of SD with regard to renal replacement therapy, particularly hemo- and peritoneal dialysis. The differences in its manifestation in men and women are compared, including hormonal imbalances—and therefore fertility, libido, and sexual satisfaction—the experience of depression and anxiety, and QOL. The impact of comorbidities and the iatrogenic causes of SD are described. This review also presents validated scales for screening and diagnosis of SD in CKD patients and outlines novel therapies and strategies for the effective management of SD. Increased prevalence of CKD invariably increases the number of patients with SD, and it is crucial for health care professional teams to become familiar with the clinical tools used to manage this sensitive and under-quantified field. As a known predictor of QOL, sexual function should become a point of focus in the pursuit of patient-centered care, particularly as we seek to achieve as “normal” a life as possible for individuals who receive dialysis.

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Section: Sd and Comorbiditiesmentioning

confidence: 99%

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Chou

Kiebalo

Jagiello

et al. 2021

Life

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“…Studies reported that menopausal women at the age of 55 and above are more prone to develop atherosclerosis [4, 5]. Oestrogen deficiency in women or postmenopausal women has been linked to the rapid increase in CVD [6]. Postmenopause is a condition when the menstrual cycle permanently ceases due to natural depletion of ovarian oocytes due to aging.…”

Section: Introductionmentioning

confidence: 99%

Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil

Nazri

Fauzi

Buang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Gynura procumbens (Lour.) Merr. (GP) has been reported in previous studies to possess antihyperlipidaemic, antioxidative, and cardioprotective properties. This study was aimed to determine the effect of standardised 80% ethanol extract of GP on lipid profiles and oxidative status of hypercholesterolemic rats. Postmenopausal (PM) Sprague-Dawley rats were ovariectomised and fed with 2% cholesterol diet fortified with five times heated palm oil to develop hyperlipidaemia status. Two doses of the extract (250 and 500 mg/kg) and atorvastatin (10 mg/kg) were administered once daily via oral gavage for 24 weeks. Systolic blood pressure (SBP) was increased during the first month in the postmenopausal group and decreased with GP supplementation. Lipid droplets accumulation was shown at the tunica media (TM) area of the aorta in the postmenopausal group and reduced with GP supplementation. Total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL), and malondialdehyde (MDA) levels increased (p < 0.05) at 3 and 6 months in the postmenopausal group and were reduced with GP supplementation. GP also increased high-density lipoprotein (HDL) level in the postmenopausal group. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were reduced in the postmenopausal group compared to control in the sham group but increased (p < 0.05) with GP supplementation. The results showed that the higher dose of GP (500 mg/kg) gave better effect. GP has the ability to reduce oxidative stress and prevent membrane cell damage through antioxidant enzyme activity modification and lipid profile changes in postmenopausal rats related to atherosclerosis.

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“…44 Patients of all ages experience sexual challenges, and patients with diabetes and hypertension experience an even more significant burden of disease. 49,50,51,52,53,54,55 As doctors are expected to serve the best overall benefit or the best interest of the patient, many researchers have concluded that screening for sexual dysfunction must be a clinical priority when dealing with patients living with chronic disease. 2,56 Best interest should also imply giving attention to holistic well-being, although it has been shown that patients' preferences and subjective illness experiences are often not a consideration in clinical judgement or decision-making.…”

Section: Discussionmentioning

confidence: 99%

Sexual history taking: Doctors’ clinical decision-making in primary care in the North West province, South Africa

Pretorius

Couper

Mlambo

2021

African Journal of Primary Health Care & Family Medicine

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Background: Clinical reasoning is an important aspect of making a diagnosis for providing patient care. Sexual dysfunction can be as a result of cardiovascular or neurological complications of patients with chronic illness, and if a patient does not raise a sexual challenge, then the doctor should know that there is a possibility that one exists and enquire.Aim: The aim of this research study was to assess doctors’ clinical decision-making process with regards to the risk of sexual dysfunction and management of patients with chronic illness in primary care facilities of the North West province based on two hypothetical patient scenarios.Setting: This research study was carried out in 10 primary care facilities in Dr Kenneth Kaunda health district, North West province, a rural health district.Methods: This vignette study using two hypothetical patient scenarios formed part of a broader grounded theory study to determine whether sexual dysfunction as comorbidity formed part of the doctors’ clinical reasoning and decision-making. After coding the answers, quantitative content analysis was performed. The questions and answers were then compared with standard answers of a reference group.Results: One of the doctors (5%) considered sexual dysfunction, but failed to follow through without considering further exploration, investigations or management. For the scenario of a female patient with diabetes, the reference group considered cervical health questions (p = 0.001) and compliance questions (p = 0.004) as standard enquiries, which the doctors from the North West province failed to consider. For the scenario of a male patient with hypertension and an ex-smoker, the reference group differed significantly by expecting screening for mental health and vision (both p = 0.001), as well as for HIV (p 0.001). The participating doctors did not meet the expectations of the reference group.Conclusion: Good clinical reasoning and decision-making are not only based on knowledge, intuition and experience but also based on an awareness of human well-being as complex and multidimensional, to include sexual well-being.

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Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis

Cited by 27 publications

References 29 publications

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil

Sexual history taking: Doctors’ clinical decision-making in primary care in the North West province, South Africa

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