Sexual dysfunction related to typical and atypical antipsychotics in drug naive psychotic patients

Saad, Ahmed; Khalifa, Doaa Ahmed; Elmissiry, Mostafa; Elbatrawy, Amira; Taha, Sameh

doi:10.1097/01.xme.0000461673.36113.c8

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…The current systematic review and meta-analysis contained a total of 15 full-text articles that examined sexual dysfunction and its contributing factors among psychiatric patients and were published until 2024. The included articles were conducted in the five African countries: six studies were conducted in Nigeria [ 31 – 36 ], four studies were carried out in Ethiopia [ 37 – 40 ], three articles were in Egypt [ 41 – 43 ], one study was done in South Africa [ 44 ] and the other one study was conducted in Tunisia [ 45 ]. Concerning the study design, most of the included studies (thirteen studies) were conducted using a cross-sectional study design, and the other two remaining articles were prospective cohort and case-control studies.…”

Section: Resultsmentioning

confidence: 99%

Sexual dysfunction among people with mental illness in Africa: A systematic review and meta-analysis study

Fentahun,

Melkam,

Tadesse

et al. 2024

PLoS ONE

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Background Sexual dysfunction is the most frequent health problem among psychiatric patients. This could be the result of both the nature of the illness itself and the side effects of prescribed psychotropic medications. It also significantly affects an individual’s general well-being, interpersonal relationships, self-esteem, and treatment outcomes. Therefore, the current systematic review and meta-analysis was conducted to determine the combined prevalence of sexual dysfunction and its correlated factors among people with mental illness. Methods We retrieved eligible primary studies using various search databases like PubMed, EMBASE, Science Direct, African Journal Online, Google Scholar, and Psychiatry Online. The report of this systematic review was reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. We used standardized data extraction checklists and STATA version 14 for data extraction and analysis, respectively. The I-squared statistics test was used to check statistical heterogeneity within the included articles. Publication bias was assessed using a funnel plot and the Egger test. To estimate the overall prevalence and correlated factors of sexual dysfunction, a random effects model meta-analysis was employed. Results In this meta-analysis, a total of 15 primary studies with 2849 psychiatric patients were included. The overall pooled prevalence of sexual dysfunction among psychiatric patients in Africa was 58.42% (95% CI: 49.55, 67.28). Having older age (OR = 1.92, 95% CI: 1.28, 2.87), longer duration of illness (OR = 2.60, 95% CI: 1.14, 5.93), history of relapse (OR = 3.51, 95% CI: 1.47, 8.43), poor quality of life (OR = 3.89, 95% CI: 2.15, 7.05), and antipsychotic medications (OR = 2.99, 95% CI: 1.84, 4.86) were significantly associated with sexual dysfunction. Conclusion This meta-analysis revealed that approximately two-thirds of psychiatric patients in Africa are affected by sexual dysfunction. Therefore, the findings of this study recommend that when evaluating psychiatric patients, health professionals should focus more on sexual dysfunction. It is also essential to promote awareness and incorporate sexual health assessment and intervention into mental health services to reduce the overall burden of the problem.

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Section: Resultsmentioning

confidence: 99%

Sexual dysfunction among people with mental illness in Africa: A systematic review and meta-analysis study

Fentahun,

Melkam,

Tadesse

et al. 2024

PLoS ONE

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“…Risperidone affects sexual desire the most in both sexs, 48 followed by erectile and ejaculatory dysfunction in men and arousal disorder and vaginal dryness in women 6,30,36,49 . Olanzapine has less impact on sexual dysfunction than risperidone 26 .…”

Section: Discussionmentioning

confidence: 99%

“…19 However, risperidone caused a higher impairment of sexual functioning in the domains of desire and arousal compared with olanzapine in our study, which is comparable with the results of EIRE (Estudio de Investigaci n de Resultados en Esquizofrenia-outcomes research study in schizophrenia) study. 30 Risperidone affects sexual desire the most in both sexs, 48 followed by erectile and ejaculatory dysfunction in men and arousal disorder and vaginal dryness in women. 6,30,36,49 Olanzapine has less impact on sexual dysfunction than risperidone.…”

Section: Antipsychotics and Sexual Dysfunctionmentioning

confidence: 99%

Association Between Sexual Dysfunction and Dose of Atypical Antipsychotics: Essential to Learn the Basics

Sanman

Udaykumar

Yadiyal

2022

The Journal of Clinical Pharma

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There is paucity of data on sexual dysfunction associated with atypical antipsychotics in Indian population. We estimated the prevalence of sexual dysfunction and assessed dose dependency, if any, in patients on monotherapy of atypical antipsychotics. This cross-sectional study analyzed the data from patients with F20 to F29 (International Classification of Diseases 10 th Revision, ICD-10) receiving monotherapy of risperidone (group 1), olanzapine (group 2), or quetiapine (group 3) for at least 4 weeks. The sexual function of participants was assessed using Arizona sexual experiences (ASEX) scale. Chlorpromazine (CPZ) equivalent dose and doses in terms of dose years were calculated. Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation were used for analysis. Of the 154 subjects, 65.58% were males, with 44%, 48%, and 8% receiving risperidone, olanzapine, and quetiapine, respectively. The mean duration of treatment was 20.9 weeks. Lower ASEX scores were reported with quetiapine. The differences in mean ASEX scores between groups 1 and 2 were statistically significant for sex drive (P = .016), sexual arousal (P = .025), and overall score (P = .037). Sexual dysfunction was more frequent with risperidone (48.5%) than with olanzapine (28.4%) and quetiapine (0%). In group 1, the duration of therapy positively correlated with the mean scores of sexual desire (P = .003) and arousal (P = .033), but this was not the case for group 2 (receiving olanzapine). The mean CPZ equivalent doses were comparable between the groups (P = .064); those receiving <200 mg CPZ dose equivalents showed greater sexual impairment. We conclude that the occurrence of atypical antipsychotic-induced sexual dysfunction is not dose dependent. Olanzapine has a better safety profile in terms of sexual dysfunction, whereas the data reflecting the experience with quetiapine are insufficient.

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“…Antipsychotic drugs: When it comes to males, antipsychotics may cause erectile dysfunction, ejaculatory failure, and loss of libido. When it comes to women, it often causes menstruation problems, dry vagina, lack of desire, and orgasmic dysfunction [80]. Haloperidol and thioridazine are examples of first-generation antipsychotics, which are older medicines that are known to produce a variety of sexual dysfunctions.…”

Section: Effect Of Medications On Sexualitymentioning

confidence: 99%

Sexual Disorders in Females with Bipolar Disorder

E. El-Sorogy,

M. El-Hamady,

S. Mohamed

et al. 2024

Benha Journal of Applied Sciences

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Two or more attacks of hypomania, mania, depression, or mixed episodes, interspersed with euthymic intervals, constitute bipolar disorder (BD). Among the leading causes of disability globally, BD is a major concern. Among all mental health illnesses, sexual dysfunction is underestimated and more common in the general population compared to those with mental health issues. The purpose of this article is to provide a comprehensive overview of the sexual abnormalities and behaviors that are often seen in bipolar female patients. Final thoughts: Sexual dysfunctions and abnormal behaviors were more common in women with BD. Manic episodes are associated with increased hazardous sexual conduct in people with BD. Additionally, it was mentioned that couples' sexual pleasure is negatively impacted by hypersexuality during manic episodes and hyposexuality during depressed episodes, and this effect typically continues into the times between episodes. On the other hand, sex may be linked to negative emotions rather than diminished desire during depressed periods. Individuals with mental health illnesses have a greater chance of sexual difficulties damaging personal interactions and quality of life.

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Sexual dysfunction related to typical and atypical antipsychotics in drug naive psychotic patients

Cited by 4 publications

References 32 publications

Sexual dysfunction among people with mental illness in Africa: A systematic review and meta-analysis study

Sexual dysfunction among people with mental illness in Africa: A systematic review and meta-analysis study

Association Between Sexual Dysfunction and Dose of Atypical Antipsychotics: Essential to Learn the Basics

Sexual Disorders in Females with Bipolar Disorder

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