Sexual dysfunction with the use of antidepressants in a tertiary care mental health setting - a retrospective case series

Lahon, Kingshuk; Shetty, Harsha M; Paramel, Amith; Sharma, Gyaneswar

doi:10.4103/0976-500x.81913

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…The adverse events (e.g., nausea, vomiting, hair loss) associated with the use of many antineoplastic drugs are sufficiently distressing to a number of patients with cancer that they do not take their medication in the manner intended. The ability of certain drugs to cause sexual dysfunction is a reason for noncompliance by some patients, with the antipsychotic agents, antidepressants (TCAs 30%, MAO inhibitors 40%, SSRIs 60%–70%, venlafaxine 70% and duloxetine 46% in Western populations) ( Lahon et.al., 2011 ) and antihypertensive agents (thiazide-class diuretics, β-blockers, and centrally acting sympathoplegics reported) being implicated most frequently ( Al-Khaja et.al., 2016 ). Patients may be asymptomatic or Symptoms subside: Situations frequently occur in which patients do not complete a full course of antibiotic therapy once they feel that the infection has been controlled.…”

Section: Factors Associated With Non-compliancementioning

confidence: 99%

Patient Compliance: Fact or Fiction?

Mohiuddin

2019

Innov Pharm

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The word ‘compliance’ comes from the Latin word complire, meaning to fill up and hence to complete an action, transaction, or process and to fulfil a promise. In the Oxford English Dictionary, the relevant definition is ‘The acting in accordance with, or the yielding to a desire, request, condition, direction, etc.; a consenting to act in conformity with; an acceding to; practical assent”. Compliance with therapy is simply patients understanding of medication, motivation toward having this medication is a prescribed manner with the belief that the prescriber and prescribed medicine will be beneficial for his well-being. Although this is often the case, in a number of situations, the physician and pharmacist have not provided the patient with adequate instructions or have not presented the instructions in such a manner that the patient understands them. Nothing should be taken for granted regarding the patient’s understanding of how to use medication, and appropriate steps must be taken to provide patients with the information and counseling necessary to use their medications as effectively and as safely as possible. 20% to 30% of new prescriptions are never filled at the pharmacy. Medication is not taken as prescribed 50% of the time. For patients prescribed medications for chronic diseases, after six months, the majority take less medication than prescribed or stop the medication altogether. There are both federal and state laws that make using or sharing prescription drugs illegal. If someone take a pill that was prescribed to someone else or give that pill to another person, not only is it against the law, it's extremely dangerous. Article Type: Commentary

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Section: Factors Associated With Non-compliancementioning

confidence: 99%

Patient Compliance: Fact or Fiction?

Mohiuddin

2019

Innov Pharm

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“…Based on a measure defined by the World Health Organization, we estimated the duration of antidepressant treatment as the number of defined daily doses, relating to the average amount of a drug needed for long-term therapeutic use. However, prescribed daily doses might differ [30], which also may lead to misclassification of treatment duration. The assumption may have biased our estimate of the effect of the treatment durations on affective disorders.…”

Section: Strengths and Limitations Of The Studymentioning

confidence: 99%

Long-term prenatal effects of antidepressant use on the risk of affective disorders in the offspring: a register-based cohort study

Rommel

Momen

Molenaar

et al. 2021

Neuropsychopharmacol.

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To investigate the association between intrauterine antidepressant exposure and offspring affective disorders over an 18-year follow-up period using Danish national registers. We included 42,988 singletons born during 1998-2011 and followed-up until 2016, death, emigration, or date of first affective disorder diagnosis. Children were categorised into two groups according to maternal antidepressant use within 2 years before and during pregnancy: continuation (use before and during pregnancy) or discontinuation (use before but not during pregnancy). The outcome was an affective disorders diagnosis in the offspring based on secondary/tertiary care records and primary care prescription data. Hazard ratios (HR) of affective disorders were estimated using Cox regression models. To consider confounding by shared environmental or genetic factors, we investigated the effect of paternal antidepressant use on the risk for affective disorders. Affective disorders were diagnosed in 1538 children. Children whose mothers continued antidepressants during pregnancy had an increased risk of affective disorders (HR = 1.20, 95% CI = 1.08-1.34), compared with children whose mothers discontinued before pregnancy. Similarly, continued paternal antidepressant use during pregnancy was associated with higher risk for offspring affective disorders (HR = 1.29, 95% CI = 1.12-1.49), compared to discontinuation. Based on data from primary and secondary/tertiary care, maternal antidepressant use during pregnancy was associated with an increased risk of affective disorders in the offspring. As similar associations were observed in children whose fathers continued antidepressant use across the pregnancy period, the observed association may be attributable to the underlying parental psychopathology, rather than the direct intrauterine exposure to antidepressants.

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“…It is often difficult or impossible to ascertain what is caused by depression and what caused by the antidepressant, their interaction or even other factors. Lahon et al [4] suggest that a complaint by a patient of sexual dysfunction might either indicate a failure to respond to treatment or the side effects of the drug. The large majority of commonly prescribed antidepressants are associated with sexual side effects, which often lead to noncompliance to the treatment.…”

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confidence: 99%

Sexual Dysfunction, Depression and Antidepressants: A Translational Approach

Olivier¹,

Franco²,

Waldinger³

et al. 2017

Sexual Dysfunction

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Major depression is frequently associated with sexual dysfunctions. Most antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), induce additional sexual side effects and, although effective antidepressants, deteriorate sexual symptoms, which are the main reason that patients stop antidepressant treatment. Many strategies have been used to circumvent the additional sexual side effects, but results are rather disappointing. Recently, new antidepressants have been introduced, vilazodone and vortioxetine, which seem to lack sexual side effects in the early registration trials. Much research with large numbers of depressed patients and adequate methodological tools still has to confirm in daily use the absence of sexual side effects of new antidepressants. Animal models that in an early phase of drug development may predict putative sexual side effects of new antidepressants are extremely useful and could speed up development of new antidepressants. A rat model of sexual behavior is described that has a very high predictive validity for sexual side effects in man. Several characteristics of present antidepressants with regard to sexual dysfunctions are also present in the rat model and establish its validity. The animal model can also be used in the search for new psychotropics without sexual side effects or for drugs with sexual stimulating activity.

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Sexual dysfunction with the use of antidepressants in a tertiary care mental health setting - a retrospective case series

Cited by 10 publications

References 16 publications

Patient Compliance: Fact or Fiction?

Patient Compliance: Fact or Fiction?

Long-term prenatal effects of antidepressant use on the risk of affective disorders in the offspring: a register-based cohort study

Sexual Dysfunction, Depression and Antidepressants: A Translational Approach

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