Sexual Function in Males After Radiotherapy for Rectal Cancer

Bruheim, Kjersti; Guren, Marianne G.; Dahl, Alv A.; Skovlund, Eva; Balteskard, Lise; Carlsen, Erik; Fosså, Sophie D.; Tveit, Kjell Magne

doi:10.1016/j.ijrobp.2009.03.075

Cited by 84 publications

(62 citation statements)

References 21 publications

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“…Most of the previous studies that assessed the HRQL and late side effects of rectal cancer survivors were cross-sectional. In these studies more bowel and sexual dysfunction was found after RT [4][5][6], although they concluded that sexual dysfunction was primarily caused by surgery [7]. In the few available longitudinal HRQL studies, the follow-up was at most until four years after treatment [8][9][10].…”

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confidence: 99%

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

et al. 2015

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Background: Total mesorectal excision (TME) combined with preoperative short-term radiotherapy (PRT) reduces local recurrence rates in rectal cancer treatment. However, treatment with radiotherapy increased morbidity and did not result in a longer survival. The aim of this analysis is to provide a comprehensive longitudinal overview of the health-related quality of life (HRQL) and symptoms experienced by rectal cancer patients in the Dutch randomized TME trial from baseline until 14 years after treatment. Methods: Rectal cancer patients (n ¼1530) were randomly allocated to PRT (5 Â 5 Gy) followed by TME or to TME alone. At baseline, 3, 6, 12, 18, and 24 months, 5 years and 14 years after treatment HRQL was evaluated in surviving patients (n ¼606, at 14 years after treatment). Results: None of the general symptoms differed significantly between PRT + TME and TME. However, in both treatment arms the general symptoms were increased at the diagnosis of rectal cancer, after surgery and by aging. With PRT + TME bowel symptoms were increased, specifically more fecal incontinence was reported at all time points, resulting in more use of pads for fecal incontinence (PRT + TME vs. TME at 5 years 51.5% vs. 30.5%, respectively, and at 14 years 56.4% vs. 37.1%, respectively).Conclusions: This longitudinal analysis shows that general symptoms in both groups are increased at the diagnosis of rectal cancer, after surgery and by aging, but not by RT. However, irradiated patients reported more bowel dysfunction at all time points.

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confidence: 99%

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

et al. 2015

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“…These complications may result from thermal damage, ischemic injury, nerve stretching, ligation and the local inflammatory effects to the hypogastric nerve and the sacral splanchnic plexus during pelvic dissection. Injury to the sympathetic supply results in detrusor instability and ejaculatory difficulties, whereas injury to the parasympathetic supply results in poor detrusor contraction and erectile dysfunction (ED) [14,[28][29][30][31] Table 8: Total number of patients handled by the authors.…”

Section: Sexual Functionmentioning

confidence: 99%

Impact of Total Mesorectal Excision on Bladder and Sexual Function in Rectal Cancer

Dar¹,

Parray²,

Bhat³

et al. 2017

Cancer Surg

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“…Neoadjuvant chemoradiotherapy is the standard treatment for advanced rectal cancer, and chemoradiotherapy can effectively reduce the tumor size, increase the rates of successful resection and sphincter preservation, and reduce the local recurrence rate (1,2). However, complications of concurrent chemoradiotherapy, such as fecal incontinence, urinary incontinence, and sexual dysfunction, cannot be ignored (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Value of endorectal ultrasonography in measuring the extent of mesorectal invasion and substaging of T3 stage rectal cancer

et al. 2017

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Abstract. The present study aimed to determine the value of endorectal ultrasound (ERUS) and magnetic resonance imaging (MRI) for T3 rectal cancer, and substaging of T3 rectal cancer by measuring the extent of mesorectal invasion (EMI). The clinical data of patients with rectal cancer who were admitted to the general surgical department of Peking Union Medical College Hospital (Beijing, China) were reviewed and analyzed. Two ultrasound practitioners independently measured the EMI on ERUS, and a radiologist measured the EMI on MRI. The consistency of ERUS measurements between the two doctors was assessed using intraclass consistency (ICC) analysis. T3 stages were subdivided into T3a (EMI ≤5 mm) and uT3b (EMI >5 mm). The accuracy of MRI and ERUS in T3 rectal cancer, and T3 substaging of rectal cancer was assessed and compared according to the pathological results. The Bland-Altman scatter plot demonstrated good consistency between the ERUS measurement and pathology measurement. Furthermore, the consistency of the ERUS measurement between the two doctors was good (ICC, 0.9344; 95% confidence interval, 0.8789-0.9645). The diagnostic accuracies for T3 rectal cancer, for the two ultrasound doctors and for MRI were 86.9% (53/61), 85.2% (52/61), and 90.2% (55/61), respectively. The accuracy, sensitivity and specificity for the two individual ultrasound doctors in the substaging of T3 tumors were 79.1% (34/43), 66.7% (10/15), and 85.7% (24/28), compared with 67.4% (31/43), 60% (9/15), and 82.1% (23/28), respectively. The accuracy of MRI in the substaging of T3 tumors was 86.0% (37/43), which was not statistically higher compared with those of ERUS (P>0.05). In conclusion, ERUS is a valuable tool for measuring the EMI and substaging T3 rectal cancer, and thus, can be complementary to MRI in selecting the appropriate treatment for rectal cancer.

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Sexual Function in Males After Radiotherapy for Rectal Cancer

Cited by 84 publications

References 21 publications

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial

Impact of Total Mesorectal Excision on Bladder and Sexual Function in Rectal Cancer

Value of endorectal ultrasonography in measuring the extent of mesorectal invasion and substaging of T3 stage rectal cancer

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