Sexual function in patients with Parkinson's disease.

Singer, Carlos; Weiner, William J.; Sanchez‐Ramos, Juan; Ackerman, Mark D.

doi:10.1136/jnnp.54.10.942

Cited by 31 publications

(13 citation statements)

References 2 publications

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“…ED was reported by 54-79% of men with PD [Bronner et al 2004;Sakakabira et al 2001;Koller et al 1990]. A total of 60% of men with PD reported ED, as compared with 37.5% in age-matched controls [Singer et al 1991]. Many males were also unable to ejaculate and to achieve an orgasm.…”

Section: Introductionmentioning

confidence: 99%

Management of sexual dysfunction in Parkinson’s disease

Bronner¹,

Vodušek²

2011

Ther Adv Neurol Disord

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Nonmotor symptoms, among them sexual dysfunction, are common and underrecognized in patients with Parkinson disease; they play a major role in the deterioration of quality of life of patients and their partners. Loss of desire and dissatisfaction with their sexual life is encountered in both genders. Hypersexuality (HS), erectile dysfunction and problems with ejaculation are found in male patients, and loss of lubrication and involuntary urination during sex are found in female patients. Tremor, hypomimia, muscle rigidity, bradykinesia, 'clumsiness' in fine motor control, dyskinesias, hypersalivation and sweating may interfere with sexual function. Optimal dopaminergic treatment should facilitate sexual encounters of the couple. Appropriate counselling diminishes some of the problems (reluctance to engage in sex, problems with ejaculation, lubrication and urinary incontinence). Treatment of erectile dysfunction with sildenafil and apomorphine is evidence based. HS or compulsive sexual behaviour are side effects of dopaminergic therapy, particularly by dopaminergic agonists, and should be treated primarily by diminishing their dose. Neurologists should actively investigate sexual dysfunction in their Parkinsonian patients and offer treatment, optimally within a multidisciplinary team, where a dedicated professional would deal with sexual counselling.

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Section: Introductionmentioning

confidence: 99%

Management of sexual dysfunction in Parkinson’s disease

Bronner¹,

Vodušek²

2011

Ther Adv Neurol Disord

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“…Sexual function declines with advancing age, but appears to be over-represented in chronic illnesses, including PD [49]. Sixty percent of men with PD have symptoms of sexual dysfunction compared with 37% of control individuals [50]. Symptoms of sexual dysfunction can include sexual dissatisfaction, erectile dysfunction, impaired ejaculation or orgasm, and, in women, diminished vaginal lubrication.…”

Section: Sexual Dysfunctionmentioning

confidence: 98%

“…Helping the patient and partner to expand their definitions of sexuality beyond vaginal penetration and ejaculation may prove useful. Adjunctive measures, including the use of lubrication, should be recommended if needed [50]. Treatment of erectile dysfunction in men with PD consists of vacuum-constriction devices, implantable penile prostheses, and intracavernosal injections of vasodilators.…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Autonomic nervous system dysfunction in Parkinson’s disease

Zesiewicz¹,

Baker²,

Wahba³

et al. 2003

Curr Treat Options Neurol

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Autonomic nervous system (ANS) dysfunction is common in Parkinson's disease (PD), affects 70% to 80% of patients, and causes significant morbidity and discomfort. Autonomic nervous system dysfunction symptoms in PD include sexual dysfunction, swallowing and gastrointestinal disorders, bowel and bladder abnormalities, sleep disturbances, and derangements of cardiovascular regulation, particularly, orthostatic hypotension. Autonomic nervous system dysfunction in PD may be caused by an underlying degenerative process that affects the autonomic ganglia, brainstem nuclei, and hypothalamic nuclei. Anti-parkinsonian medications can cause or worsen symptoms of ANS dysfunction. The care of a PD patient with ANS dysfunction relies on its recognition and directed treatment, including coordinated care between the neurologist and appropriate subspecialist. Pharmacotherapy may be useful to treat orthostasis, gastrointestinal, urinary, and sexual dysfunction.

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“…The disease has been associated with the destruction of the dopaminecontaining cells in the substantia nigra in the brain [20,21]. Erectile dysfunction is commonly associated with Parkinson disease [22,23]. It has been demonstrated that the central nervous system dopaminergic pathways in the medial preoptic area of the brain interact with the nonadrenergic, noncholinergic pathways to mediate penile erection [24].…”

Section: Parkinson Diseasementioning

confidence: 99%

Neurogenic erectile dysfunction

Lue

2001

Clinical Autonomic Research

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Penile erection is a neurovascular event modulated by psyche and hormones. Erectile dysfunction (ED) has been classified as psychogenic, arteriogenic, neurogenic, endocrinologic, and cavernosal, based on the organs that are involved in penile erection. Among these types, neurogenic ED may be the most common, probably because a deficiency of neurotransmitters is the final common pathway in many diseases and conditions. This review discusses the physiology, pathophysiology, diagnosis, and treatment of erectile function and dysfunction, as well as strategies for future research.

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Sexual function in patients with Parkinson's disease.

Cited by 31 publications

References 2 publications

Management of sexual dysfunction in Parkinson’s disease

Management of sexual dysfunction in Parkinson’s disease

Autonomic nervous system dysfunction in Parkinson’s disease

Neurogenic erectile dysfunction

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