Sexual function in teenagers after multimodal treatment of pelvic rhabdomyosarcoma: A preliminary report

Macedo, António; Ferreira, Pedro Vanalle; Barroso, Ubirajara; Demarchi, Guilherme T.S.; Garrone, Gilmar; Liguori, Riberto; Caran, Eliana Maria Monteiro; Ortiz, Valdemar

doi:10.1016/j.jpurol.2010.06.001

Cited by 19 publications

(8 citation statements)

References 16 publications

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“…Studies in RMS have so far used reporting by healthcare professionals in the medical chart to document toxicity. Patient reported outcomes and data on HRQOL among patients with RMS are limited to small studies of survivors of perineal or pelvic disease . There have been no previous published reports prospectively assessing HRQOL or symptoms during therapy for RMS.…”

Section: Discussionmentioning

confidence: 99%

Patterns of chemotherapy‐induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group

Gupta

Yun

Anderson

et al. 2017

Pediatric Blood & Cancer

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Background We sought to determine whether adolescents with metastatic alveolar rhabdomyosarcoma (ARMS) or embryonal RMS (ERMS) had a different event-free survival (EFS) compared with younger patients, and to identify treatment-related factors (adverse events, AEs) that may be associated with differences in outcome. Methods The prevalence of AEs in adolescents older than 13 years was compared with that in patients less than or equal to 13 years of age (Fisher exact test) in patients enrolled onto ARST0431. EFS by age and histology was compared by log–rank test. Results Of 109 patients, 60 (55%) were older than 13 years; they were more likely to have nausea (17 vs. 4%, P = 0.06) and pain (20 vs. 6%, P = 0.05) compared with younger patients. Adolescents were less likely to complete therapy (63 vs. 76%) and more likely to have unplanned dose modifications outside of protocol guidelines (23 vs. 2.7%). The 3-year EFS was 26% (95% confidence interval [CI]: 15–38) for adolescents compared with 46% (95% CI: 32–60) for those less than or equal to 13 years (P = 0.011). Forty-two (59%) adolescents with ARMS had a 3-year EFS of 13% (95% CI: 2–23) compared with 30% (95% CI: 10–51) for those less than or equal to 13 years (P = 0.032). EFS was comparable between older and younger patients with ERMS (64 vs. 55%, P = 0.53). Conclusions Although there was a significant difference in EFS and protocol compliance by age, the differences in age-related toxicity are unlikely to account for this. Observed differences in pain and nausea by age could be real or be dependent on patient reporting of symptoms. Future studies in RMS should include patient-reported outcomes to better evaluate health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Patterns of chemotherapy‐induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group

Gupta

Yun

Anderson

et al. 2017

Pediatric Blood & Cancer

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“…16,17 According to these studies, high-risk patients experience moderate to severe urinary and sexual symptoms at 5 years after radiotherapy. Unfortunately, such studies in pediatric populations are mostly preliminary; 18 however, they suggest that the outcome, even though initially acceptable, deteriorates over time. 11,19,20 For this reason, not only OS and tumor control, but also long-term complications and toxicity must be taken into account when comparing different therapeutic strategies.…”

Section: Discussionmentioning

confidence: 99%

Reconstructive option after radical mutilating surgery in children with genitourinary rhabdomyosarcoma: When sparing the bladder is not an option

et al. 2016

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Objectives: To present versatile surgical reconstructive techniques and their outcomes in pediatric patients with genitourinary rhabdomyosarcoma. Methods: We retrospectively analyzed the oncological and urological outcomes of seven patients treated between 1992 and 2014 according to the Cooperative Weichteilsarkom Studiengruppe protocols. Intergroup Rhabdomyosarcoma Study staging: local, six patients; and IV, one patient. Histology: embryonal, five patients; unclassified, one patient; triton tumor one patient. Surgical treatment included: cystectomy, uterectomy and partial vaginectomy, one patient; radical cystectomy, two patients; cystectomy, one patient; cystectomy with partial prostatectomy, one patient; partial cystectomy, one patient; and partial prostatectomy, one patient. Results: All patients were alive in complete remission at last follow up. In four cases, ileal conduit with ureteral reimplantation with serous-lined extramural tunnel (Abol-Enein technique) was carried out, which was followed by conversion into ileal continent bladder with continent appendiceal stoma for clean intermittent catheterization in three patients. In one boy, partial cystectomy and continent reconstruction was carried out during a single surgical procedure. One child with incontinent urinary diversion is still awaiting a continence solution. One child after partial prostatectomy is continent without any voiding disturbances. Conclusions: The timing and extent of radical surgery for treatment of genitourinary rhabdomyosarcoma depend on the local anatomical conditions, and the response to previous chemo-and radiotherapy. Cystectomy followed by various reconstructive techniques still remains an important option in the local treatment.

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“…The degree of dysfunction varies, with approximately half of the boys having unsatisfactory erections while others appear to have normal erectile function and satisfaction. 34 Women with a history of pelvic rhabdomyosarcoma are at risk for long-term adverse effects. Some of these effects result from the operative oncologic intervention required including hysterectomy, complete or partial vaginectomy, complete or partial cystectomy, and oophorectomy.…”

Section: Genitourinary Malignanciesmentioning

confidence: 99%

Transitional care in pediatric urology

Lambert

2015

Seminars in Pediatric Surgery

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Sexual function in teenagers after multimodal treatment of pelvic rhabdomyosarcoma: A preliminary report

Cited by 19 publications

References 16 publications

Patterns of chemotherapy‐induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group

Patterns of chemotherapy‐induced toxicities and outcome in children and adolescents with metastatic rhabdomyosarcoma: A report from the Children's Oncology Group

Reconstructive option after radical mutilating surgery in children with genitourinary rhabdomyosarcoma: When sparing the bladder is not an option

Transitional care in pediatric urology

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