Sexual Function in Women with Colorectal/Anal Cancer

Canty, Jocelyn; Stabile, Cara; Milli, Lisania; Seidel, Barbara; Goldfrank, Deborah J.; Carter, Jeanne

doi:10.1016/j.sxmr.2018.12.001

Cited by 32 publications

(29 citation statements)

References 55 publications

(96 reference statements)

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“…1st quartile: <=14.5 (least active), 2nd quartile: 14.5-26, 3rd quartile: >26-43.8, 4th quartile (most active): >43.8. 7 Comorbidity is classified according to a modified the Charlson Comorbidity Index (CCI), excluding cancer.…”

Section: Resultsmentioning

confidence: 99%

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Risk of Pharmacological or Hospital Treatment for Depression in Patients with Colorectal Cancer–Associations with Pre-Cancer Lifestyle, Comorbidity and Clinical Factors

Kjær

Moustsen-Helms

Albieri

et al. 2021

Cancers

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We investigated the risk of depression in colorectal cancer (CRC) patients and associated risk factors. The 1324 patients with CRC and 6620 matched cancer-free participants from the Diet, Cancer and Health study were followed for up to 16 years for either a first hospitalization for depression or antidepressant prescription after diagnosis of CRC cancer or study entry date. Information on the outcome and covariates was retrieved from the Danish Colorectal Cancer Group database, the national health registries and questionnaires. Cumulative incidence of depression was estimated, and Cox regression models were used to evaluate the association between risk factors and depression incidence. During follow-up, 191 (14.4%) patients with CRC and 175 (2.6%) cancer-free comparison persons experienced depression. After adjustments, in the first year after cancer diagnosis, patients with CRC had a 12-fold higher hazard compared with the cancer-free population (HR, 12.01; 95% CI, 7.89–18.28). The risk decreased during follow-up but remained significantly elevated with an HR of 2.65 (95% CI, 1.61–4.36) after five years. Identified risk factors were presence of comorbidities, advanced disease stage and use of radiotherapy, while life style factors (pre-cancer or at diagnosis) and chemotherapy did not seem to contribute to the increased risk.

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Section: Resultsmentioning

confidence: 99%

“…The physical late effects of CRC and its treatments are well known and include among other things gastrointestinal and urogenital problems [6], sexual dysfunction [7] and neuropathy [8,9]. This group of patients may also live with a colostomy as a result of the surgical intervention, giving rise to specific problems.…”

Section: Introductionmentioning

confidence: 99%

Risk of Pharmacological or Hospital Treatment for Depression in Patients with Colorectal Cancer–Associations with Pre-Cancer Lifestyle, Comorbidity and Clinical Factors

Kjær

Moustsen-Helms

Albieri

et al. 2021

Cancers

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“…Fertility and sexual health are also major concerns; however, 64% of survey participants indicated that a medical professional did not talk to them about fertility preservation during diagnosis or treatment [20]. Sexual dysfunction has been reported to be one of the most common longterm effects of CRC treatment [28] and may be of particular concern for young adult patients [29]. Based on these data, we identified psychosocial services, fertility, and sexual health as the key clinical programmatic elements.…”

Section: Developing a Young Onset Colorectal Programmentioning

confidence: 99%

A Coordinated Clinical Center for Young Onset Colorectal Cancer

et al. 2021

Self Cite

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“…Existing research has mainly focused on women who have breast or gynecological cancer (Chen et al, 2018;Ljungman et al, 2018;Condorelli et al, 2019) and men who have prostate cancer (Cakar et al, 2013;Fode et al, 2017;Clavell-Hernández et al, 2018) as well on mixed populations such as colon cancer patients (Canty et al, 2019;Stulz et al, 2020). Some cancer types, including gynecological or prostate cancer directly affect the sexual organs.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Sexual Problems and Related Psychosocial Characteristics in Cancer Patients—Findings From an Epidemiological Multicenter Study in Germany

et al. 2021

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BackgroundMultimodal cancer treatments are often associated with sexual problems. Identifying patients with sexual problems could help further elucidate serious issues with their sexuality and thus promote or maintain patients’ sexual health. We aimed to assess the occurrence of sexual problems in patients across different tumor locations and to explore associated sociodemographic, medical and psychosocial factors.MethodsWe included 3,677 cancer patients (mean age 58 years, age range 18–75 years, 51.4% women) from a large epidemiological multicenter study in Germany on average 13.5 months after cancer diagnosis. The occurrence and frequency of sexual problems were assessed via a binary item on the problem checklist of the Distress Thermometer (DT). Controlled associations of these problems with sociodemographic, medical and psychosocial factors including distress (DT), anxiety (GAD-7), depression (PHQ-9), quality of life (EORTC-QLQ-C30), and social support (SSUK-8) are analyzed using logistic regression analysis.ResultsWe found that 31.8% of patients reported sexual problems, with a significant higher proportion in men (40.5%) compared to women (23.7%), OR 2.35, 95% CI [1.80–3.07] and a higher proportion in patients with a partner (35.6%) compared to those without a partner (3.5%), OR 2.83, 95% CI [2.17–3.70]. Tumor location was associated with occurrence of sexual problems: patients with cancer, affecting the male genital organs had the highest chance for sexual problems, OR 2.65, 95% CI [1.18–3.95]. There was no significant difference in the occurrence of sexual problems between age groups OR 0.99, 95% CI [2.13–3.53] and type of therapy (e.g., operation OR 0.91, 95% CI [0.72–1.15]). Sexual problems were further associated with elevated levels of anxiety, OR 1.05, 95% CI [1.02–1.10], less social support, OR 0.93, 95% CI [0.90–0.97] and lower quality of life in terms of impaired functioning (e.g., social function, OR 0.99, 95% CI [0.99–1.00]).ConclusionsSexual problems are commonly reported by patients. Male patients and those living with a partner are more likely to report sexual problems. Sexual problems are associated with different aspects of well-being. The findings imply the practical relevance to screen for sexual problems among patients and identified groups that should be particularly monitored.

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Sexual Function in Women with Colorectal/Anal Cancer

Cited by 32 publications

References 55 publications

Risk of Pharmacological or Hospital Treatment for Depression in Patients with Colorectal Cancer–Associations with Pre-Cancer Lifestyle, Comorbidity and Clinical Factors

Risk of Pharmacological or Hospital Treatment for Depression in Patients with Colorectal Cancer–Associations with Pre-Cancer Lifestyle, Comorbidity and Clinical Factors

A Coordinated Clinical Center for Young Onset Colorectal Cancer

Frequency of Sexual Problems and Related Psychosocial Characteristics in Cancer Patients—Findings From an Epidemiological Multicenter Study in Germany

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